Results 81 to 90 of about 1,781,035 (303)

Unconstrained generation of synthetic antibody–antigen structures to guide machine learning methodology for antibody specificity prediction

, 2022
Machine learning (ML) is a key technology for accurate prediction of antibody–antigen binding. Two orthogonal problems hinder the application of ML to antibody-specificity prediction and the benchmarking thereof: the lack of a unified ML formalization of
Hochreiter, Sepp, Prósz, Aurél, Abram, Krzysztof, Snapkov, Igor, Scheffer, Lonneke, Mehta, Brij Bhushan, Lund-Johansen, Fridtjof, Sandve, Geir Kjetil, Mathisen, Ingvild Frøberg, Slabodkin, Andrei, Miho, Enkelejda, Rawat, Puneet, Haff, Ingrid Hobæk, Chernigovskaya, Maria, Widrich, Michael, Vu, Mai Ha, Greiff, Victor, Hobæk Haff, Ingrid, Klambauer, Günter, Olar, Axel, Olar, Alex, Robert, Philippe A., Akbar, Rahmad, Frank, Robert, Pavlović, Milena, Smorodina, Eva, Haug, Dag Trygve Tryslew   +26 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Characterization of Primate Antibody Responses to Administered Murine Monoclonal Immunoglobulin

The International Journal of Biological Markers, 1990
Murine monoclonal antibodies (MAb) are currently being assessed for their utility as tools in cancer management. Anti-murine immunoglobulin responses have been observed in many patients receiving monoclonal antibody treatment. In this study, we evaluated
D.E. Milenic, B. Detrick, J.C. Reynolds, D. Colcher   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Bactericidal human monoclonal antibody 1B1 shows specificity for meningococcal factor H binding protein variant 2 and displaces human factor H

FASEB BioAdvances
Thousands of disease cases and hundreds of deaths occur globally each year due to invasive meningococcal disease. Neisseria meningitidis serogroup B (MenB) is the leading cause of such disease in developed countries.
Daniele Veggi, Chelsy C. Chesterman, Laura Santini, Ying Huang, Nicola Pacchiani, Jeannette Sierra, Lynn Chen, Jason Laliberte, Federica Bianchi, Roberta Cozzi, Elisabetta Frigimelica, Domenico Maione, Oretta Finco, Matthew J. Bottomley   +13 more
doaj   +1 more source

Doses of Immunogen Contribute to Specificity Spectrums of Antibodies against Aflatoxin

Toxins, 2017
Research about antibody specificity spectra was conducted to develop single-specific antibodies or broad-specific antibodies. Aflatoxins, as one class of high-toxicity mycotoxins, were selected as the research targets to investigate the effect of the ...
Peiwu Li, Jing Wu, Li Zhang, Zhiyong Fan, Tingting Yu, Feng Jiang, Xiaoqian Tang, Zhaowei Zhang, Wen Zhang, Qi Zhang   +9 more
doaj   +1 more source

Antibody-drug conjugates for cancer therapy

, 2020
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Antibody–drug conjugates (ADCs) are novel drugs that exploit the specificity of a monoclonal antibody (mAb) to reach target antigens expressed on cancer cells for the delivery of a potent ...
Sagun Parakh (9493061), Umbreen Hafeez (9474611), Andrew Scott (9483443), Hui Gan (9477872)   +3 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Smooth muscle antibodies and cryoglobulinemia are associated with advanced liver fibrosis in Brazilian hepatitis C virus carriers

Brazilian Journal of Infectious Diseases
Cryoglobulinemia and non-organ-specific-autoantibody are biomarkers of autoimmunity of the chronic infection caused by hepatitis C virus (HCV).
Luis Jesuino de Oliveira Andrade, Paulo Roberto Santana de Melo, Ajax Mercês Atta, Maria Luiza Brito de Sousa Atta, Larissa Santana de Jesus, Gabriel Menezes de Sousa, Carolina Alves Costa Silva, Raymundo Paraná   +7 more
doaj   +1 more source