Results 141 to 150 of about 1,017,137 (336)

From antibody specificity to T cell recognition. [PDF]

J Exp Med, 2021
Kim HJ, Cantor H.
europepmc   +1 more source

Defining HLA-Specific Antibodies [PDF]

American Journal of Transplantation, 2014
D, Middleton, J, Jones, D, Lowe
openaire   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Data from Effective Inhibition of Bone Morphogenetic Protein Function by Highly Specific Llama-Derived Antibodies

, 2023
Silvia Calpe, Koen Wagner, Mohamed El Khattabi, Lucy Rutten, Cheryl Zimberlin, Edward Dolk, C. Theo Verrips, Jan Paul Medema, Hergen Spits, Kausilia K. Krishnadath   +9 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The physiological limits of bispecific monoclonal antibody tissue targeting specificity

mAbs
Bispecific monoclonal antibodies (bsmAbs) are expected to provide targeted drug delivery that overcomes the dose-limiting toxicities often accompanying antibody-drug conjugates (ADC) in clinical practice.
Armin Sepp, Felix Stader, Abdallah Derbalah, Cong Liu, Adriana Zyla, Iain Gardner, Masoud Jamei   +6 more
doaj   +1 more source

Multiple Tolerization Subtractive Immunization (MTSI) Protocol: Effects on Mice and Monoclonal Antibody Specificity. [PDF]

Front Immunol, 2021
de Lima Fontes M, Neves FML, Santos KS, Fusco-Almeida AM, Giannini MJSM, Felisbino SL, Deffune E, Moroz A.   +7 more
europepmc   +1 more source

Phosphatidylserine-targeting antibody induces M1 macrophage polarization, promotes myeloid derived suppressor cell differentiation and boosts tumor-specific immunity [PDF]

, 2013
Xianming Huang, Yi Yin, Dan Ye, Rolf A. Brekken, Philip E. Thorpe   +4 more
openalex   +1 more source

Dataset relative to article "Sensitivity and specificity of a commercial ELISA test for anti-MAG antibodies in patients with neuropathy"

, 2021
Giuseppe Liberatore, Claudia Giannotta, Blesson Punnen Sajeev, Emanuela Morenghi, Fabrizia Terenghi, Francesca Gallia, Pietro Emiliano Doneddu, Fiore Manganelli, Dario Cocito, Massimiliano Filosto, Giovanni Antonini, Giuseppe Cosentino, Girolama Alessandra Marfia, Angelo Maurizio Clerici, Giuseppe Lauria, Tiziana Rosso, Guido Cavaletti, Eduardo Nobile‐Orazio   +17 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source