Results 171 to 180 of about 10,170,244 (414)
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
The physiological limits of bispecific monoclonal antibody tissue targeting specificity
mAbsBispecific monoclonal antibodies (bsmAbs) are expected to provide targeted drug delivery that overcomes the dose-limiting toxicities often accompanying antibody-drug conjugates (ADC) in clinical practice.
Armin Sepp +6 more
doaj +1 more source
Large scale paired antibody language models [PDF]
arXivAntibodies are proteins produced by the immune system that can identify and neutralise a wide variety of antigens with high specificity and affinity, and constitute the most successful class of biotherapeutics. With the advent of next-generation sequencing, billions of antibody sequences have been collected in recent years, though their application in ...
arxiv
The specifity of serological precipitation [PDF]
, 1946 Precipitative mixing experiments have been conducted with the aid of a turbidimeter and a darkfield microscope. The results of these experiments, correlated with observations of macroscopic features, indicate that serological precipitation is largely ...
Lanni, Frank
core
INCIDENCE AND SPECIFICITY OF THE ANTIBODY FOR A DISTINCTIVE CONSTITUENT OF THE BROWN-PEARCE TUMOR [PDF]
, 1945 I.Z. MacKenzie, John G. Kidd
openalex +1 more source
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
Affinity Maturation Enhances Antibody Specificity but Compromises Conformational Stability
Cell Reports, 2019 Summary: Monoclonal antibodies (mAbs) have recently emerged as one of the most promising classes of biotherapeutics. A potential advantage of B cell-derived mAbs as therapeutic agents is that they have been subjected to natural filtering mechanisms ...
Laila Shehata +11 more
doaj
dyAb: Flow Matching for Flexible Antibody Design with AlphaFold-driven Pre-binding Antigen [PDF]
arXivThe development of therapeutic antibodies heavily relies on accurate predictions of how antigens will interact with antibodies. Existing computational methods in antibody design often overlook crucial conformational changes that antigens undergo during the binding process, significantly impacting the reliability of the resulting antibodies.
arxiv
QUANTITATIVE EXPERIMENTS WITH ANTIBODIES TO SPECIFIC PRECIPITATES. II [PDF]
, 1941 Henry P. Treffers, Michael Heidelberger
openalex +1 more source
Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source