Results 171 to 180 of about 1,873,489 (255)

IgG1 versus IgG3: influence of antibody-specificity and allotypic variance on virus neutralization efficacy. [PDF]

Front Immunol
Kallolimath S, Sun L, Palt R, Föderl-Höbenreich E, Hermle A, Voss L, Kleim M, Nimmerjahn F, Gach JS, Hitchcock L, Chen Q, Melnik S, Eminger F, Lux A, Steinkellner H.   +14 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

An explainable language model for antibody specificity prediction using curated influenza hemagglutinin antibodies. [PDF]

Immunity
Wang Y, Lv H, Teo QW, Lei R, Gopal AB, Ouyang WO, Yeung YH, Tan TJC, Choi D, Shen IR, Chen X, Graham CS, Wu NC.   +12 more
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Molecular and structural basis of anti-DNA antibody specificity for pyrrolated proteins. [PDF]

Commun Biol
Anan Y, Itakura M, Shimoda T, Yamaguchi K, Lu P, Nagata K, Dong J, Ueda H, Uchida K.   +8 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Identification of antibody specificity using adsorption-elution studies with incompatible packed red cell unit. [PDF]

Asian J Transfus Sci
Nivedita K, Mukherjee S, Mishra D, Datta N, Sahu A, Prakash S.   +5 more
europepmc   +1 more source

Analysis of Histone Antibody Specificity with Peptide Microarrays. [PDF]

J Vis Exp, 2017
Cornett EM, Dickson BM, Rothbart SB.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

HLA class I peptide polymorphisms contribute to class II DQβ0603:DQα0103 antibody specificity. [PDF]

Nat Commun
Shih NR, Nong T, Murphey C, Lopez-Cepero M, Nickerson PW, Taupin JL, Devriese M, Nilsson J, Matignon MB, Bray RA, Lee JH.   +10 more
europepmc   +1 more source