Evaluation of mycobacterium tuberculosis antigen 6 by enzyme linked immunosorbent assay (ELISA) [PDF]
, 1994 Mycobacterium tuberculosis Antigen 6, which is a 30 KDa protein purified by DEAE-Cellulose chromatography, was evaluated by enzyme linked immunosorbent assay (ELISA) for its sensitivity and specificity for antibody detection in sera from patients with ...
Jawahar, M S +3 more
core
ON THE PRESENCE IN ANTIPNEUMOCOCCUS SERUM OF TYPE-SPECIFIC PROTECTIVE ANTIBODY NOT NEUTRALIZED BY HOMOLOGOUS SPECIFIC SOLUBLE SUBSTANCE [PDF]
, 1931 Albert B. Sabin
openalex +1 more source
Molecular Oncology, EarlyView.Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti +8 more
wiley +1 more source
S$^2$ALM: Sequence-Structure Pre-trained Large Language Model for Comprehensive Antibody Representation Learning [PDF]
arXivAntibodies safeguard our health through their precise and potent binding to specific antigens, demonstrating promising therapeutic efficacy in the treatment of numerous diseases, including COVID-19. Recent advancements in biomedical language models have shown the great potential to interpret complex biological structures and functions.
arxiv
Engineering a Molecular Missile for Pancreatic Cancer Detection: Vector Design [PDF]
, 2018 Pancreatic cancer, though rare, is expected to be the second-leading cause of cancer-related death by 2030 (Rahib et al., 2014). CA 19-9 is currently the most widely used biomarker for pancreatic cancer detection, but detection of CA 19-9 relies on the ...
Castillo, Sophia, Zhang, Zhiwen
core +1 more source
The Neutralization of Pneumococcal Capsular Polysaccharide by the Antibodies of Type-Specific Antisera [PDF]
, 1938 Kenneth Goodner +2 more
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Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source
Use of Iodide Salts in the Isolation of Antibodies and the Dissolution of Specific Immune Precipitates [PDF]
, 1967 Stratis Avraméas, Thérèse Ternynck
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Molecular Oncology, EarlyView.The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita +1 more
wiley +1 more source
A SARS-CoV-2 Interaction Dataset and VHH Sequence Corpus for Antibody Language Models [PDF]
arXivAntibodies are crucial proteins produced by the immune system to eliminate harmful foreign substances and have become pivotal therapeutic agents for treating human diseases. To accelerate the discovery of antibody therapeutics, there is growing interest in constructing language models using antibody sequences.
arxiv