Results 201 to 210 of about 1,017,137 (336)

Borrowing a DNA repair enzyme to fine-tune antibody specificity. [PDF]

PLoS Biology, 2006
Liza Gross
doaj   +1 more source

First site-specific conjugation method for native goat IgG antibodies via glycan remodeling at the conserved Fc region

Michael E. Dolan, Amissi Sadiki, Lei Wang, Yan Wang, Christopher Barton, Sheldon F. Oppenheim, Zhaohui Sunny Zhou   +6 more
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Inference and design of antibody specificity: From experiments to models and back. [PDF]

PLoS Comput Biol
Fernandez-de-Cossio-Diaz J, Uguzzoni G, Ricard K, Anselmi F, Nizak C, Pagnani A, Rivoire O.   +6 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

IgG1 versus IgG3: influence of antibody-specificity and allotypic variance on virus neutralization efficacy. [PDF]

Front Immunol
Kallolimath S, Sun L, Palt R, Föderl-Höbenreich E, Hermle A, Voss L, Kleim M, Nimmerjahn F, Gach JS, Hitchcock L, Chen Q, Melnik S, Eminger F, Lux A, Steinkellner H.   +14 more
europepmc   +1 more source

Comparison of nucleic acid and protein immunization for induction of antibodies specific for HIV-1 gp120 [PDF]

, 1997
Nicky M. Peet, Jane A. McKeating, Belén Ramos, Thomas Klonisch, J. Brian de Souza, Peter J. Delves, Torben Lund   +6 more
openalex   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

An explainable language model for antibody specificity prediction using curated influenza hemagglutinin antibodies. [PDF]

Immunity
Wang Y, Lv H, Teo QW, Lei R, Gopal AB, Ouyang WO, Yeung YH, Tan TJC, Choi D, Shen IR, Chen X, Graham CS, Wu NC.   +12 more
europepmc   +1 more source

Nanostructured recombinant protein particles raise specific antibodies against the nodavirus NNV coat protein in sole

, 2020
Rosemary Thwaite, Concepción Berbel, Manuel Aparicio, Débora Torrealba, Mireia Pesarrodona, Antonio Villaverde, Juan J. Borrego, Manuel Manchado, Nerea Roher   +8 more
openalex   +2 more sources