Results 211 to 220 of about 10,170,244 (414)

De novo generation of SARS-CoV-2 antibody CDRH3 with a pre-trained generative large language model

Nature Communications
Artificial Intelligence (AI) techniques have made great advances in assisting antibody design. However, antibody design still heavily relies on isolating antigen-specific antibodies from serum, which is a resource-intensive and time-consuming process. To
Haohuai He, Bing He, Lei Guan, Yu Zhao, Feng Jiang, Guanxing Chen, Qingge Zhu, Calvin Yu-Chian Chen, Ting Li, Jianhua Yao   +9 more
doaj   +1 more source

The CH1α domain of mucosal gp41 IgA contributes to antibody specificity and antiviral functions in HIV-1 highly exposed Sero-Negative individuals. [PDF]

PLoS Pathog, 2020
Khamassi M, Xu L, Rey J, Duchemin M, Bouceba T, Tuffery P, Tudor D, Bomsel M.   +7 more
europepmc   +1 more source

A SARS-CoV-2 surrogate virus neutralization test based on antibody-mediated blockage of ACE2–spike protein–protein interaction

Nature Biotechnology, 2020
C. Tan, W. Chia, X. Qin, Pei Liu, M. Chen, Charles Tiu, Zhiliang Hu, V. Chen, B. Young, W. Sia, Yee-Joo Tan, Randy Foo, Yongxiang Yi, D. Lye, D. Anderson, Lin‐Fa Wang   +15 more
semanticscholar   +1 more source

Quantitative Studies of Febrile Tolerance and Levels of Specific Antibody Evoked by Bacterial Endotoxin* [PDF]

, 1965
John H. Mulholland, Sheldon Wolff, Anne L. Jackson, Maurice Landy   +3 more
openalex   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

AntiFold: Improved antibody structure-based design using inverse folding [PDF]

arXiv
The design and optimization of antibodies requires an intricate balance across multiple properties. Protein inverse folding models, capable of generating diverse sequences folding into the same structure, are promising tools for maintaining structural integrity during antibody design.
arxiv  

DETECTION OF STREPTOCOCCAL GROUP-SPECIFIC ANTIBODIES IN HUMAN SERA [PDF]

, 1965
Walter W. Karakawa, C. Kirk Osterland, Richard M. Krause   +2 more
openalex   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

AntibodyFlow: Normalizing Flow Model for Designing Antibody Complementarity-Determining Regions [PDF]

arXiv
Therapeutic antibodies have been extensively studied in drug discovery and development in the past decades. Antibodies are specialized protective proteins that bind to antigens in a lock-to-key manner. The binding strength/affinity between an antibody and a specific antigen is heavily determined by the complementarity-determining regions (CDRs) on the ...
arxiv  

Streptococcal group-specific antibodies: occurrence of a restricted population following secondary immunization. [PDF]

, 1968
Julian B. Fleischman, Dietmar G. Braun, R. M. Krause   +2 more
openalex   +1 more source