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Antibodies as specific chaperones

Biochemistry (Moscow), 2004
Protein folding is often accompanied by formation of non-native conformations leading to protein aggregation. A number of reports indicate that antibodies can facilitate folding and prevent aggregation of protein antigens. The influence of antibodies on folding is strictly antigen specific.
D N, Ermolenko   +2 more
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Specific anti-antibodies

Experientia, 1972
Les anti-anticorps pourraient avoir des applications theerapeutiques dans certains etats allergiques, les maladies d'auto-immunisation et dans les greffes des tissues. Les auteurs montrent la possibilite de stimuler la formation des anti-anticorps specifiques contre les anticorps produits par des antigenes relativement simples comme l'albumine, le ...
N, Radoiu, F A, Zydeck, R R, Bennett
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Specificity of Fish Antibody

The Journal of Immunology, 1966
Summary Fish anti-BSA differed from rabbit anti-BSA in at least three ways. 1) The fish antibody had three equivalence points, 50, 25 and 6.25 mg/ml, whereas rabbit antibody had only one, 0.31 mg/ml. 2) The fish antibody had a larger amount of low-avid antibody. 3) The fish antibody migrated in the same direction but more slowly.
D L, Everhart, A M, Shefner
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Specific Antibody Deficiencies

Immunology and Allergy Clinics of North America, 2015
Patients with specific antibody deficiency (SAD) have a deficient immunologic response to polysaccharide antigens. Such patients experience sinopulmonary infections with increased frequency, duration, or severity compared with the general population. SAD is definitively diagnosed by immunologic challenge with a pure polysaccharide vaccine in patients 2
Luke A, Wall   +2 more
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Antibody specificity and promiscuity

Biochemical Journal, 2019
AbstractThe immune system is capable of making antibodies against anything that is foreign, yet it does not react against components of self. In that sense, a fundamental requirement of the body's immune defense is specificity. Remarkably, this ability to specifically attack foreign antigens is directed even against antigens that have not been ...
Deepti Jain, Dinakar M. Salunke
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Antimucopeptide Antibodies and Their Specificity

The Journal of Immunology, 1969
Abstract The immunochemical specificity of the common part of bacterial mucopeptide, which is composed of the polysaccharide backbone and the peptide side chains, was studied in a heterologous system consisting of soluble, nondialyzable, lysozymedigest of M. lysodeikticus cell walls as test antigen and anti-S.
M, Rolicka, J T, Park
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Specificities of antibodies to oestrogens

Journal of Steroid Biochemistry, 1972
Abstract Until recently attempts to endow antigenicity to 17β-oestradiol have invariably been made by conjugating protein (usually bovine serum albumin) via a hemisuccinate bridge to functional groups. Coupling in this manner produced antisera which unfortunately gave serious crossreactions with other naturally occurring oestrogens.
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Stabilization of enzymes by their specific antibodies

Enzyme and Microbial Technology, 1991
In nature, increased stability of enzymes has often been found to be associated with noncovalent protein-protein interactions. Specific antibodies should be suitable for this purpose. To test this hypothesis, we used a number of model enzymes, complexed them with their specific antibodies, and exposed them and the free enzymes to low and high ...
E Y, Shami   +3 more
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Chloramphenicol-Specific Antibody

Science, 1966
Antibody to the antibiotic chloramphenicol was obtained by immunizing rabbits with a chloramphenicol derivative coupled to bovine gamma globulin. Production of antibody was demonstrated by the precipitin and complement fixation reactions with "reduced chloramphenicol" coupled to rabbit serum albumin as the test antigen.
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Effects of specific antigen and specific antibody on the kinetics of in vitro antibody production

Cellular Immunology, 1980
Abstract An in vitro model system was used to probe the regulation of an ongoing antibody response. This system employed lymphocyte cell cultures prepared from the draining lymph nodes of rabbits immunized with glutaraldehyde-polymerized or heat-aggregated human serum albumin.
E J, Greene, J G, Tew, G A, Miller
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