Results 241 to 250 of about 969,569 (304)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Seroprevalence Screening of Chronic Aspergillus Infection in a Post-Tuberculosis Cohort in Senegal: A Cross-Sectional Study Comparing ELISA and Rapid Diagnostic Tests. [PDF]

Mycoses
Mariama T, Mbaye NI, Djiby S, Alpha DM, Khadim D, Cheikh SM, Mouhamadou N, Daouda N, Diop NF, Louise F, David D, Sadikh BA.   +11 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

A Novel Adaptive Platform for Rapid, Simple Flow-Based Antibody Detection Devices Predicts NAb Levels to SARS-CoV-2. [PDF]

Pathog Immun
Markmann AJ, Bhowmik DR, Jiang B, Vanna UP, Van Hoy M, Wang F, Hou YJ, Margolis DM, Baric RS, de Silva AM, Bartelt LA.   +10 more
europepmc   +1 more source

Transplant Glomerulitis: Paying Due Deference to T-cell Mediated Rejection and Antibody Independent Mechanisms. [PDF]

Kidney Int Rep
Randhawa PS, Vali SP.
europepmc   +1 more source

Research Progress on Point-of-Care Testing Technology for Mycoplasma Pneumonia. [PDF]

Int J Gen Med
Guo Z, Hu R, Wang J, Zhou M, Zhu K, Xu Y.   +5 more
europepmc   +1 more source

Identifying Insulin Autoantibodies With Differential Risk in Type 1 Diabetes With a Novel Bridging ELISA. [PDF]

Diabetes
Jia X, Zhang C, Waugh K, Miao D, Michels AW, Rewers MJ, Yu L.   +6 more
europepmc   +1 more source

Synthetic peptide-based latex agglutination test for the detection of <i>Bacillus anthracis</i> spores from soil samples. [PDF]

RSC Adv
Nishanth MAD, Vergis J, Joshi V, Jindal N, Murag S, Prameela DR, Pollumahanti N, Malik SVS, Barbuddhe SB, Rawool DB.   +9 more
europepmc   +1 more source

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Phage-specific antibodies

Current Opinion in Biotechnology, 2021
Antibodies specific to phage virions have been observed many times, both in animals and in humans. Phages induce the T-dependent type of immune response, which is fundamental for immunological memory and long retention of abilities to recognize and respond to foreign epitopes.
Katarzyna, Gembara, Krystyna, Dąbrowska
openaire   +2 more sources