Results 161 to 170 of about 10,530,811 (405)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Designing organometallic compounds for catalysis and therapy [PDF]

, 2012
Bioorganometallic chemistry is a rapidly developing area of research. In recent years organometallic compounds have provided a rich platform for the design of effective catalysts, e.g. for olefin metathesis and transfer hydrogenation.
Abraha Habtemariam, Aird, Alama, Alama, Alberto, Allardyce, Allen, Allen, Ana M. Pizarro, Anand, Ang, Ang, Anna Louisa Noffke, Arancibia, Barragan, Barry, Barry, Barry, Barry, Bergamo, Bergamo, Betanzos-Lara, Betanzos-Lara, Betanzos-Lara, Brewster, Bugarcic, Bugarcic, Canivet, Carrión, Caruso, Casini, Casini, Casini, Chaplin, Chen, Chen, del Pozo, Desmard, Dorcier, Dorcier, Dougan, Dougan, Dyson, Erxleben, Feng, Fernandez, Filak, Fu, Fu, Fujii, Giannini, Gormen, Gossens, Grau, Grguric-Sipka, Grubbs, Gröger, Guichard, Guo, Guo, Habtemariam, Hambley, Hamels, Hanif, Hanif, Harris, Hartinger, Hashiguchi, Hayes, Hayward, Herman, Hindi, Hogan, Hollmann, Hu, Hull, Ito, Jafarpour, Jennerwein, Jira, Jungwirth, Kandioller, Kisova, Kljun, Kopf, Kopf-Maier, Kopf-Maier, Kopf-Maier, Kopf-Maier, Kröger, Kuninobu, Lee, Leiva, Li, Liu, Liu, Liu, Liu, Liu, Lo, Lo, Lummen, Lutz, Maenaka, Meggers, Meggers, Meggers, Melchart, Melchart, Melchart, Melendez, Mendes, Motterlini, Mross, Novakova, Novakova, Novakova, Noyori, Noyori, Oehninger, Ogo, Ogo, Olliaro, Page, Patiño, Peacock, Peacock, Peacock, Peacock, Pelletier, Peter J. Sadler, Petzold, Petzold, Pitto-Barry, Pitto-Barry, Pizarro, Plazuk, Rocamora-Reverte, Ruiz, Ruppert, Sandoval, Sanford, Sarsam, Schatzschneider, Schmid, Schäfer, Scolaro, Selander, Skinner, Sriskandakumar, Steckhan, Strohfeldt, Suss-Fink, Sweeney, Takebayashi, Tan, Therrien, Therrien, Toney, Top, Top, Top, Trnka, Turel, van der Donk, van Rijt, van Rijt, van Rijt, Vessières, Vougioukalakis, Vougioukalakis, Wang, Wang, Wang, Ward, Williams, Williams, Wong, Wu, Wu, Yabluchanskiy, Yamakawa, Yan, Yano, Yuasa, Zava, Zekri, Zhao, Zoeller   +188 more
core   +1 more source

Ferrocene-Based Compounds with Antimalaria/Anticancer Activity

Molecules, 2019
Malaria and cancer are chronic diseases. The challenge with drugs available for the treatment of these diseases is drug toxicity and resistance. Ferrocene is a potent organometallic which have been hybridized with other compounds resulting in compounds ...
Sijongesonke Peter, B. Aderibigbe
semanticscholar   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Recent advances on anticancer activity of coumarin derivatives

European Journal of Medicinal Chemistry Reports, 2022
Anjali Rawat, A. Vijaya Bhaskar Reddy
semanticscholar   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Evaluating Medicinal Plants for Anticancer Activity

The Scientific World Journal, 2014
Plants have been used for medical purposes since the beginning of human history and are the basis of modern medicine. Most chemotherapeutic drugs for cancer treatment are molecules identified and isolated from plants or their synthetic derivatives.
Elisha Solowey, Michal Lichtenstein, Sarah Sallon, Helena Paavilainen, Elaine Solowey, Haya Lorberboum-Galski   +5 more
doaj   +1 more source

Natural Product Triterpenoids and Their Semi-Synthetic Derivatives with Potential Anticancer Activity

Planta Medica, 2019
Triterpenoids are distributed widely in higher plants and are of interest because of their structural diversity and broad range of bioactivities. In particular, there is a very large literature on the propensity of a variety of triterpenoids to act as ...
Yulin Ren, A. Kinghorn, P. A. D. Kinghorn   +2 more
semanticscholar   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source