Anticancer Activity of Cyanobacteria
, 2022 A high number of peptides produced by the cyanobacteria of different genera, their unique structure and a wide spectrum of biological activities, including anticancer effect, indicates a significant biotechnological potential of these organisms. Several different types of active peptides extracted from Lyngbya spp.
Trofim, A.A., Bivol, C.M., Ţurcanu, O.
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The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
The anticancer activity of dichloromethane crude extract obtained from Calea pinnatifida
Journal of Experimental Pharmacology, 2012 Gabriela M Marchetti,1,2 Karina A Silva,3 Arianny N Santos,3 Ilza MO Sousa,3 Sirlene V Tinti,2 Glyn M Figueira,4 Mary A Foglio,1,3 João E Carvalho1,21Programa de Pós Graduação em Biologia Celular e Estrutural ...
Foglio MA +7 more
doaj
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
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Phytochemical investigation, antibacterial and anticancer activities of the extract of Momordica charantia [PDF]
, 2020 Vishal Bharat Babar +2 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Apoptosis pathway of Gelam (Melaleuca cajupati) honey on human colorectal carcinoma (HCT116) / Dr. Wan Iryani Wan Ismail and Dr. Mizaton Hazizul Hassan [PDF]
, 2013 Honey has been used for medical purposes since a long time ago. It had antimicrobial, antiviral and antiparasitic activities, and showed anti-inflammatory, antioxidant and antimutagenic effects. Previous studies demonstrated that honey may have potential
Hazizul Hassan, Mizaton +1 more
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Structure-activity consideration of novel anticancer platinum pyrimidine "greens".
, 1987 Takehiko Shimura +4 more
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