Results 111 to 120 of about 170,034 (262)

Discovery of a novel anticancer agent with both anti-topoisomerase I and II activities in hepatocellular carcinoma SK-Hep-1 cells in vitro and in vivo: Cinnamomum verum component 2-methoxycinnamaldehyde [PDF]

, 2016
Daw-Shyong Perng,1 Yu-Hsin Tsai,2 Jonathan Cherng,3 Jeng-Shing Wang,4 Kuo-Shen Chou,5 Chia-Wen Shih,6 Jaw-Ming Cherng7 1Department of Gastroenterology, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan, Republic of China; 2Sierra College, Rocklin, CA,
Perng DS, Shih CW, Chou KS, Cherng JM, Tsai YH, Wang JS, Cherng J   +6 more
core  

Glucose Deprivation‐Driven Concurrent Induction of Apoptosis/Disulfidptosis/Ferroptosis by Tumor Targeting Nanoassemblies in Triple‐Negative Breast Cancer Therapy

Advanced Functional Materials, EarlyView.
Innovative hybrid nanoassemblies installed with ferrocene, D‐α‐tocopherol succinate, and phloretin exploit the metabolic vulnerability of triple‐negative breast cancer under glucose starvation. By blocking glucose uptake, this single nanoplatform simultaneously orchestrates apoptosis, disulfidptosis, and ferroptosis to achieve synergistic and ...
Song Yi Lee, ChaeRim Hwang, Seong Eun Kim, Mrinmoy Karmakar, Seo Jin Jung, Hyeonseok Jang, Hae‐In Kim, Heejung Yang, Junmin Lee, Dae‐Duk Kim, Hyun‐Jong Cho   +10 more
wiley   +1 more source

Hydrogel Microtube Drug Carrier for Catheter‐Based Intravascular Therapy

Advanced Healthcare Materials, EarlyView.
This paper proposes hydrogel microtube carriers composed of barium alginate gel, enabling long‐term vascular retention without interrupting blood flow. Intravascular treatments have long been attracting attention for therapeutic efficacy, yet practical delivery methods remained unestablished.
Shota Sato, Hiroki Ohta, Naoki Takakura, Kentaro Kasa, Teppei Komatsu, Dai Kejia, Misato Yoshioka, Hirotaka James Okano, Hiroaki Onoe   +8 more
wiley   +1 more source

Synthesis and characterization of a isothiouronium-calix[4]arene derivative: self-assembly and anticancer activity

Beilstein Journal of Organic Chemistry
Calix[n]arenes are polyphenolic macrocycles known for their remarkable synthetic versatility, which supports their broad application in various areas, including drug discovery.
Giuseppe Granata, Loredana Ferreri, Claudia Giovanna Leotta, Giovanni Mario Pitari, Grazia Maria Letizia Consoli   +4 more
doaj   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Development of a Multigram Synthetic Route to RM-581, an Orally Active Aminosteroid Derivative Against Several Types of Cancers

Molecules
Aminosteroid derivative RM-581 stands out as an anticancer agent, supported by positive in vitro and in vivo studies on resistant cancers of the breast, prostate, and pancreas. A synthetic route has already been developed to obtain aminosteroid RM-581 in
René Maltais, Doriane de Sainte Maresville, Vincent Desrosiers, Donald Poirier   +3 more
doaj   +1 more source

Anticancer Mechanisms and Potential Anticancer Applications of Antimicrobial Peptides and Their Nano Agents [PDF]

Ziyi Dong,1,2 Xinyu Zhang,1 Qing Zhang,1 Jakkree Tangthianchaichana,1,3 Mingxue Guo,1 Shouying Du,1 Yang Lu1 1Laboratory of Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic
Guo M, Du S, Lu Y, Dong Z, Zhang X, Tangthianchaichana J, Zhang Q   +6 more
core  

Chiral Microneedle Arrays With Terahertz Chiroptical Activity With Chiral‐Plasmon‐Chiral‐Phonon Resonance

Advanced Materials, EarlyView.
ABSTRACT Microneedle arrays (MNAs) is a rapidly emerging technology with broad biomedical applications in drug delivery and biosensing. With sub‐millimeter dimensions and periodicity, MNAs possess geometries nearly ideal for biomedical devices operating within the terahertz (THz) spectral window.
Sang Hyun Lee, Hong Ju Jung, John Kim, Bum Chul Park, Caio V. C. R. da Silva, André F. de Moura, Nicholas A. Kotov   +6 more
wiley   +1 more source

Protection of Anticancer Chemotherapeutic Agents

Huli yanjiu, 1995
应用抗癌化疗药物的防护２６４０００山东省烟台市肿瘤医院孙亚平，关世杰关键词抗癌药物，防护ＰｒｏｔｅｃｔｉｏｎｏｆＡｎｔｉｃａｎｃｅｒＣｈｅｍｏｔｈｅｒａｐｅｕｔｉｃＡｇｅｎｔｓ￥ＳｕｎＹａｐｉｎｇ；ＧｕａｎＳｈｉｊｉｅ(ＭｕｎｉｃｉｐａｌＴｕｍｏｒＨ...
doaj  

Turning Unpredictable Biomolecule Adsorption to Controlled Corona Formation: Focus on Carbon Nanomaterials

Advanced Materials, EarlyView.
Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou, Yalei Hu, Jie Yu, Naoki Komatsu, Yuta Nishina, Alberto Bianco   +5 more
wiley   +1 more source