Results 221 to 230 of about 170,034 (262)

Fenbendazole as an Anticancer Agent? A Case Series of Self-Administration in Three Patients.

Case Rep Oncol
Makis W, Baghli I, Martinez P.
europepmc   +1 more source

The role of andrographolide as a potential anticancer agent against gastric cancer cell lines: a systematic review. [PDF]

PeerJ
Anis Amiera MA, Tuan Kub TN, Harun A, Mohamud R, Razian NRA, Muhammad Ismadi YK, Wan Alias WAS, Abdulrazak MH, Teni E.   +8 more
europepmc   +1 more source

A Non‐Canonical Core Transcriptional Regulatory Circuit Orchestrates Chromatin Reprogramming to Drive Osimertinib Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A non‐canonical core transcriptional regulatory circuit, composed of ID3, SMAD3, and NR2F2, drives Osimertinib resistance in non‐small cell lung cancer through super‐enhancer‐mediated activation of EPAS1, which couples neuroendocrine differentiation with ferroptosis evasion.
Aochu Liu, Zhenguo Liu, Lizhen Jiang, Andong Huang, Xinqing Lin, Xinyue Li, Bingyuan Liu, Shiwen Hu, Qiang Pan, Junjun Huang, Liyuan Yin, Liling Jiang, Wei Yi, Wenjun Mao, Yueyuan Zheng, Xianping Shi   +15 more
wiley   +1 more source

Retraction Statement: Paper by William Makis, Ilyes Baghli, and Pierrick Martinez entitled "Fenbendazole as an Anticancer Agent? A Case Series of Self-Administration in Three Patients" [Case Rep Oncol. 2025;18:856-863; https://doi.org/10.1159/000546362]. [PDF]

Case Rep Oncol
europepmc   +1 more source

Repurposing metformin as a potential anticancer agent using in silico technique. [PDF]

Daru
Mahfauz M, Yuruker O, Kalkan R.
europepmc   +1 more source

PGK1 Suppresses CD8+ T Cell‐Mediated Antitumor Immunity Through CCL2/CCR2/Tumor‐Associated Macrophages Axis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
PGK1 in tumor cells upregulates CCL2 expression through activation of the AKT/GSK‐3β/β‐catenin signaling axis, thereby promoting the recruitment and M2 polarization of TAMs and ultimately impairing the infiltration and activation of CD8+ T cells within the HCC tumor microenvironment. ABSTRACT Patients with advanced hepatocellular carcinoma (HCC) have a
Xi Liu, Jianpeng Liu, Zhihao Zhang, Xizhi Yu, Junjie Qian, Limin Ding, Qinchuan Wu, Zhe Yang, Xing‐Yu Luo, Xinjiang Ding, Rong Su, Xiaobo Yu, Yiting Qiao, Shengyong Yin, Haiyang Xie, Lin Zhou, Yuanxing Liu, Shusen Zheng   +17 more
wiley   +1 more source

Molecular docking and dynamics simulation of farnesol as a potential anticancer agent targeting mTOR pathway. [PDF]

In Silico Pharmacol
Ali T, Jan I, Ramachandran R, Bashir R, Andrabi KI, Bader GN.   +5 more
europepmc   +1 more source

Topology‐Aware Deep Learning on Higher‐Order Structures for Drug Response Prediction

Advanced Science, EarlyView.
We present TopDr, a topology‐aware deep learning framework that encodes both drugs and cell lines as multiscale simplicial complexes, capturing interactions at the 0‐, 1‐, and 2‐simplex levels. By jointly integrating local higher‐order neighborhoods and global topological structures, TopDr generates enriched representations for sensitivity prediction ...
Cong Shen, Guancen Lin, Chuan‐Shen Hu, Yong Wang   +3 more
wiley   +1 more source

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Cacalol Acetate as Anticancer Agent: Antiproliferative, Pro-Apoptotic, Cytostatic, and Anti-Migratory Effects. [PDF]

Curr Issues Mol Biol
Rostro-Alonso GO, Castillo-Montoya AI, García-Acosta JC, Aguilar-Llanos EF, Quintas-Granados LI, Villegas-Vazquez EY, García-Aguilar R, Porras-Vázquez SA, Bustamante-Montes LP, Alvarado-Sansininea JJ, Jiménez-Estrada M, Cariño-Calvo L, Carmen MG, Cortés H, Leyva-Gómez G, Figueroa-González G, Reyes-Hernández OD.   +16 more
europepmc   +1 more source