Results 31 to 40 of about 2,482,456 (261)
Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
Current Issues in Molecular Biology, 2023 Colorectal cancer (CRC) is one of the most commonly diagnosed cancers and is responsible for approximately one million deaths each year. The current standard of care is surgical resection of the lesion and chemotherapy with 5-fluorouracil (5-FU). However,
Natalia Kurowska +2 more
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Advances in Anticancer Immunotoxin Therapy [PDF]
The Oncologist, 2015 Abstract Immunotoxins are a novel class of antibody-conjugated therapeutics currently in clinical development for a variety of malignancies. They consist of an antibody-based targeting domain fused to a bacterial toxin payload for cell killing.
Christine, Alewine +2 more
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Chemotherapy and Physical Therapeutics Modulate Antigens on Cancer Cells
Frontiers in Immunology, 2022 Cancer cells possess specific properties, such as multidrug resistance or unlimited proliferation potential, due to the presence of specific proteins on their cell membranes.
Wojciech Szlasa +6 more
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Alphaviruses in Immunotherapy and Anticancer Therapy
Biomedicines, 2022 Alphaviruses have been engineered as expression vectors for vaccine development and gene therapy. Due to the feature of RNA self-replication, alphaviruses can provide exceptional direct cytoplasmic expression of transgenes based on the delivery of recombinant particles, naked or nanoparticle-encapsulated RNA or plasmid-based DNA replicons.
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Therapeutic effect of natural polyphenols against glioblastoma
Frontiers in Cell and Developmental Biology, 2022 Glioblastoma (GBM) is the most common and aggressive tumor of the central nervous system, which has a highly invasive growth pattern, which creates poor prospects for patient survival.
Ozal Beylerli +6 more
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Frontiers in Pharmacology, 2018 Acute myeloid leukemia (AML) is an aggressive hematological malignancy occurring very often in older adults, with poor prognosis depending on both rapid disease progression and drug resistance occurrence.
Michela Illiano +6 more
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Targeting senescence as an anticancer therapy
Molecular Oncology, 2022 Cellular senescence is a stress response elicited by different molecular insults. Senescence results in cell cycle exit and is characterised by multiple phenotypic changes such as the production of a bioactive secretome. Senescent cells accumulate during ageing and are present in cancerous and fibrotic lesions.
Laura Bousset, Jesús Gil
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Unusual DNA binding modes for metal anticancer complexes [PDF]
, 2009 DNA is believed to be the primary target for many metal-based drugs. For example, platinum-based anticancer drugs can form specific lesions on DNA that induce apoptosis.
Pizarro, Ana M., Sadler, P. J.
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The Nuclear Translocation of Heme Oxygenase-1 in Human Diseases
Frontiers in Cell and Developmental Biology, 2022 Heme oxygenase-1 (HO-1) is a rate-limiting enzyme in the degradation of heme to generate carbon monoxide (CO), free iron and biliverdin, which could then be converted to bilirubin by biliverdin reductase.
Qing Yang, Wenqian Wang
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Functionalization of osmium arene anticancer complexes with (poly)arginine : effect on cellular uptake, internalization, and cytotoxicity [PDF]
, 2011 Attaching peptides to metallodrugs may result in improved biological properties of the complexes. The potential use of cell penetrating peptides (CPPs) as cell delivery vectors is attractive, since directed cell uptake of (metallo)drugs remains a major ...
Rijt, Sabine H. van +7 more
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