Results 41 to 50 of about 2,482,456 (261)
Shedding Light on NF-κB Functions in Cellular Organelles
Frontiers in Cell and Developmental Biology, 2022 NF-κB is diffusely recognized as a transcriptional factor able to modulate the expression of various genes involved in a broad spectrum of cellular functions, including proliferation, survival and migration.
Giovanna Carrà +4 more
doaj +1 more source
Cutaneous Reactions Following Anticancer Drug Therapy in a Tertiary Care Centre
Journal of Nepal Medical AssociationIntroduction: Cutaneous reactions are dermatological abnormalities that can occur after anticancer drug therapy in cancer patients. Cutaneous reactions can range from mild dermatological disorders to life-threatening medical conditions and may worsen a ...
Deeptara Pathak Thapa +2 more
doaj +1 more source
Coupling dichloroacetate treatment with curcumin significantly enhances anticancer potential
, 2018 [[abstract]]BACKGROUND/AIM: Dichloroacetate (DCA) and curcumin have been shown to be potent drug candidates in cancer therapy. Our study aimed to investigate the combined effects of DCA and essential oil-blended curcumin (ECUR) using the hepatoma Huh-7 ...
Kan, PC;Chang, YJ;Chien, CS;Su, CY;Fang, HW
core +1 more source
Relationship between cardiac arrhythmias and anticancer therapy [PDF]
, 2020 Cardiotoxicity is a widespread complication of anticancer therapy. One of the most difficult manifestations of cardiotoxicity is cardiac arrhythmias. The incidence of arrhythmias in cancer patients has not been fully established because most studies had ...
A. A. Akhobekov +2 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Scientific ReportsTriple-negative breast cancer (TNBC) represents aggressive phenotype with limited treatment options due to the lack of drug targets. Natural compounds are extensively studied regarding their potential to alter the efficacy of cancer treatment Among them ...
A. Pogorzelska +6 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Two-Photon Absorption-Molecular Structure Investigation Using a Porphycene Chromophore with Potential in Photodynamic Therapy [PDF]
, 2012 Porphycenes have been shown to exhibit many advantageous properties when it comes to the application of two-photon absorption (TPA), a technique with potential use in the area of photodynamic therapy (PDT).
Paterson, Martin J; id_orcid +1 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source