Results 41 to 50 of about 2,801 (152)

Lipid-Lowering Trials Are Not Representative of Patients Managed in Clinical Practice: A Systematic Review and Meta-Analysis of Exclusion Criteria [PDF]

, 2023
BACKGROUND: Randomized clinical trials (RCTs) might not be representative of the real-world population because of unreasonable exclusion criteria. We sought to determine which groups of patients are excluded from RCTs that included lipid-lowering therapy.
Aeschbacher-Germann M., Aujesky D., Bauer D. C., Blum M. R., Del Giovane C., Gencer B., Kaiser N., Moutzouri E., Rodondi N., Speierer A.   +9 more
core   +1 more source

Subacute Therapeutic Dosing of Artemether‐Lumefantrine and Artesunate‐Amodiaquine Combination Preserves Plasma Cholesterol, Renal Antioxidant Status, and Organ Weights in Rats

Malaria Research and Treatment, Volume 2012, Issue 1, 2012., 2012
Recent instances of breakdowns of malaria control programs and the constant emergence of drug‐resistant parasites to monotherapies have shored up the use of artemisinin‐based combination therapy (ACT) as the malaria therapy of choice. We evaluated a subacute therapeutic dosing of artemether‐lumefantrine and artesunate‐amodiaquine on plasma cholesterol,
Chiagoziem A. Otuechere, Gloria Edewor, Oluwafemi Ezekiel Kale, Martins Ekor, Neena Valecha   +4 more
wiley   +1 more source

Comparative assessment of phytochemical properties of ethanolic extracts of barks of two herbal trees [PDF]

, 2018
This study serves to explore the chemical constituents of Azadirachta indica and Mangifera indica as a possible alternative sources of conventional antibiotics.
Adewale, Shamsideen, Ayoola, Akeem Ayobami, Muhammad, Sulaiman Babatunde   +2 more
core  

Evidence of heterogeneity in statin-associated type 2 diabetes mellitus risk: A meta-analysis of randomized controlled trials and observational studies [PDF]

, 2019
Aims: To conduct a meta-analysis of statin-associated type 2 diabetes mellitus (T2D) risk among randomized controlled trials (RCTs) and observational studies (OBSs), excluding studies conducted among secondary prevention populations.
Avery, C.L., Engeda, J.C., Keyserling, T.C., Lhachimi, S.K., Lund, J.L., Rosamond, W.D., Stackhouse, A., White, M.   +7 more
core   +2 more sources

Identification of links between small molecules and miRNAs in human cancers based on transcriptional responses [PDF]

The use of small molecules to target miRNAs is a new type of therapy for human diseases, particularly cancers. We proposed a novel high-throughput approach to identify the biological links between small molecules and miRNAs in 23 different cancers and ...
A Esquela-Kerscher, A Krek, A Subramanian, AJ Enright, B Karabulut, BP Lewis, C Li, C Sevignani, DP Bartel, DR Rhodes, DS Wishart, E Marras, F Gottardo, F Iorio, F Zhang, H Yang, J Lamb, JR Bertino, JW Gatson, K Gumireddy, KC Miranda, LM Coussens, M Campillos, M Kiriakidou, M Rehmsmeier, ML Sos, N Chen, P Brest, PE Blower, Q Pan, Q Yang, Q Yang, R Brentjens, R Spizzo, RE Lanford, RL Aft, S Griffiths-Jones, S Shankar, S Zhang, S Zhang, S Zheng, SA Rahman, T Vanhaecke, T Wang, V Jayaswal, V Jayaswal, W Huang da, W Li, X Zhou, Y Chen, Y Gusev, Y Li, Y Wang, YC Martin, ZW Zhang   +54 more
core   +2 more sources

STUDY ON GAS CHROMATOGRAPHY AND MASS SPECTROSCOPY ANALYSIS, ANTIOXIDANT, AND NUTRITIVE PROPERTIES OF AERVA LANATA (L.) JUSS. COLLECTED FROM SELECTED REGIONS OF SHIMOGA, KARNATAKA, INDIA [PDF]

, 2019
Objective: Aerva lanata (L.) Juss., the plant ethanolic extract was subjected to gas chromatography and mass spectroscopy, antioxidant, and nutritive experiment using standard methods.
MS, PADMASHREE, PRASAD YADAV, VENAKTESH, R, ASHWATHANARAYANA   +2 more
core   +1 more source

Screening of the secondary metabolites of the crude extracts of an antiviral herbal formulation using gc-ms/ms and lc-ms/ms [PDF]

This study describes the screening of secondary metabolites of the n-hexane, methanol, and ethanol extracts and the ethyl acetate layer of the medicinal herb formulation, coded BHA using GC-MS/MS. The formulation was and is still used in the treatment of
Isaac Manase Onoka, John Joseph Makangara   +1 more
core   +2 more sources

Hepatoprotective effects of a novel trihoney against nonalcoholic fatty liver disease: a comparative study with atorvastatin [PDF]

, 2020
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disorder worldwide with no curative therapy. The aim of this study was to investigate the hepatoprotective effects of a novel Trihoney against biochemical and histological ...
Azahari, Nuraniza, Che Mohamad, Che Anuar, Hamad Alfarisi, Hamad Abdulsalam, Hamad Mohamed, Zenab, Hamdan, Asmah Hanim, Ibrahim, Muhammad   +5 more
core   +2 more sources

Molecular dynamics simulations and drug discovery [PDF]

, 2011
This review discusses the many roles atomistic computer simulations of macromolecular (for example, protein) receptors and their associated small-molecule ligands can play in drug discovery, including the identification of cryptic or allosteric binding ...
A Babakhani, A Ivetac, B Ma, B Ma, B Roux, B Roux, BJ Grant, BL Tembe, BR Brooks, C Bouzat, C Chipot, C Chipot, C Peter, C Ulens, CJ Tsai, D Hamelberg, D Hamelberg, DA Case, DB Kitchen, DE Koshland, DE Shaw, DJ Hazuda, E Fischer, F Schwab, G Hong, J Andrew McCammon, J Michel, J Wang, J Yang, JA McCammon, JA McCammon, Jacob D Durrant, JC Phillips, JD Chodera, JD Durrant, JD Durrant, JD Durrant, JD Durrant, JE Lennard-Jones, JH Lin, JH Lin, JR Schames, JT Kim, L Kale, LEW LaConte, M Christen, MS Friedrichs, P Cieplak, PRL Markwick, PY Ren, R Brenke, R Bruschweiler, RE Amaro, RE Amaro, RP Feynman, S Kumar, SA Adcock, SJ Teague, TT Talley, W Liu, WD Cornell, WF van Gunsteren, WL Jorgensen, WL Jorgensen, XX Ge, Y Bourne, Y Shan, Y Wang   +67 more
core   +4 more sources

Rosuvastatina e ciprofibrato no tratamento da dislipidemia em pacientes com HIV Rosuvastatin and ciprofibrate in the treatment of dyslipidemia in patients with HIV

Arquivos Brasileiros de Cardiologia, 2012
FUNDAMENTO: A dislipidemia secundária à terapia antirretroviral potente nos pacientes com HIV está associada à significativa elevação da morbimortalidade cardiovascular por doença aterosclerótica, sendo, portanto, necessário tratamento imediato e eficaz.
Hamilton Domingos, Rivaldo Venâncio da Cunha, Anamaria Mello Miranda Paniago, Albert Schiaveto de Souza, Renata London Rodrigues, João Américo Domingos   +5 more
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