Results 81 to 90 of about 1,055,250 (236)

Anticholinergic effect on cognition (AEC) of drugs commonly used in older people [PDF]

, 2016
Objective: Use of anticholinergic drugs in older people is associated with increased risk of cognitive decline and of dementia and death. Method: We identified drugs widely used in older people and attempted to classify their anticholinergic effect on ...
Bishara, Delia, Daniel Harwood, Harwood, Daniel, Taylor, David M.; id_orcid, Sauer, Justin, Justin Sauer, David M. Taylor, Delia Bishara   +7 more
core   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Impact of the Anticholinergic Burden on Disease-Specific Symptoms in Parkinsonian Syndromes

Brain Sciences
Background: Anticholinergic adverse effects pose a relevant threat to patients, in particular elderly and cognitively impaired patients. Patients with Parkinsonian syndromes are especially at risk from anticholinergic adverse effects due to the often ...
Romina Mahmoudi, Stephan Greten, Linda Veith Sanches, Lea Krey, Sarana Ulaganathan, Günter U. Höglinger, Johannes Heck, Florian Wegner, Martin Klietz   +8 more
doaj   +1 more source

Mechanism-Informed Pharmacotherapy Optimization and Deprescribing: A Redox-Mitochondrial Framework. [PDF]

Pharmacol Res Perspect
From cumulative drug burden to mitochondrial stress and functional decline. The graphical abstract summarizes the central concept of the review, illustrating how cumulative pharmacotherapy exposure may contribute to redox–mitochondrial stress and thereby reduce biological and functional resilience.
Martinc B.
europepmc   +2 more sources

Phloroglucinol inhibits human ureteral contractions via activation of cAMP‐PKA pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Phloroglucinol is used to treat renal colic, especially when non‐steroidal anti‐inflammatory drugs are contraindicated. This study aimed to clarify its mechanism by examining effects on human ureteral contractility and underlying signalling pathways. Experimental Approach Urinary levels of neurokinin A (NKA), substance P
Hanwen Liu, Ruize Xu, Zihan Guan, Lei Liu, Guangda Lv, Weibo Chen, Jiliang Wen, Jianing Liu, Jieke Yan, Fangxin Gong, Pan Xiao, Xiulin Zhang, Lei Zhang   +12 more
wiley   +1 more source

Voice Fundamental Frequency Variation and Statin Therapy

Clinical Otolaryngology, EarlyView.
ABSTRACT Objectives Statins are considered a first‐line treatment for dyslipidaemia, being the most frequently prescribed medicine worldwide. However, statin therapy has been associated with several adverse effects, including statin‐associated myopathy, which may manifest with symptoms such as myalgia, muscle stiffness, and cramps.
Luca Francesco Parata, Paola Andreozzi, Lydia Thaleia Tzigkie, Marco de Vincentiis, Diletta Angeletti, Massimo Fusconi   +5 more
wiley   +1 more source

A 1% glycopyrronium bromide cream for topical treatment of severe primary axillary hyperhidrosis in adolescents: safety, local tolerability, systemic exposure and efficacy from an open‐label phase II study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Primary axillary hyperhidrosis (PAHH) results from dysregulation of the autonomic nervous system and typically begins during puberty. Treatment options for adolescents remain limited. This open‐label phase II study evaluated the safety, local tolerability, systemic exposure, and efficacy of 1% GPB cream over 8 weeks in
Rolf‐Markus Szeimies, Ana Kilic, Hubert Reich, Birgit Berger, Erik Schulze zur Wiesche, Leonie Litzka, Katharina Schramm, Susanne Heimstaedt‐Muskett, Clarissa Masur   +8 more
wiley   +1 more source

Anticholinergic Drugs – Functional Antidotes for the Treatment of Tabun Intoxication

, 2004
Summary: 1. To study the influence of antidotes on tabun-induced neurotoxicity, the rats were injected intramuscularly with organophosphate tabun (LD50).
Gabriela Krejčová, Jiří Kassa
core   +1 more source

Charting the course of Sjögren's disease: A historical analysis of scientific progress

European Journal of Oral Sciences, EarlyView.
Abstract Sjögren's disease (SjD) bears the name of the Swedish ophthalmologist Henrik Sjögren. His 1933 doctoral thesis on keratoconjunctivitis sicca ignited interest, yet much remains under debate. SjD is an autoimmune disorder that primarily affects the exocrine glands, particularly the salivary and lacrimal glands, leading to a dryness of the eyes ...
Diego Ustárroz Cantali, Fabiola Reis de Oliveira, Denise Cantarelli Machado, Moisés Evandro Bauer   +3 more
wiley   +1 more source

Anticholinergic Accumulation: A Slumbering Interaction between Drugs and Food Supplements

, 2015
Many compounds display anticholinergic effects which might give rise to cognitive impairment and even delirium. These side effects are caused by their ability to bind to muscarinic receptors in our brain.
Jansen, E.H., Haenen, G.R.; id_orcid, Vrolijk, M.F., Vrolijk, M.F.; id_orcid, Haenen, G.R., Opperhuizen, A., Bast, A.   +6 more
core   +1 more source