Results 11 to 20 of about 11,001 (169)

An Albumin-Oligonucleotide Assembly for Potential Combinatorial Drug Delivery and Half-Life Extension Applications

Molecular Therapy: Nucleic Acids, 2017
The long blood circulatory property of human serum albumin, due to engagement with the cellular recycling neonatal Fc receptor (FcRn), is an attractive drug half-life extension enabling technology. This work describes a novel site-specific albumin double-
Matthias Kuhlmann, Jonas B.R. Hamming, Anders Voldum, Georgia Tsakiridou, Maja T. Larsen, Julie S. Schmøkel, Emil Sohn, Konrad Bienk, David Schaffert, Esben S. Sørensen, Jesper Wengel, Daniel M. Dupont, Kenneth A. Howard   +12 more
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Coagulopathy in COVID-19

Lung India, 2021
Hemostatic derangement is a hallmark in severe COVID-19. Markedly elevation of D-dimer and fibrinogen degradation product levels were observed in patients with severe COVID-19 higher and 71.4% of nonsurvivors met the International Society of Thrombosis ...
Ka U Lio, Parth Rali
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Venous thromboembolism in COVID 19 infection: Prevalence and practice of prophylaxis - A narrative

Indian Journal of Vascular and Endovascular Surgery, 2021
The aims of this review are to ascertain the true prevalence of venous thromboembolism (VTE) in critically ill COVID 19 patients, to explore the strategy regarding prophylaxis and whether intensified prophylaxis is required for critically ill patients ...
U Vasudeva Rao, M D Wasim
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Anticoagulant Rodenticides, Islands and Animal Welfare Accountancy

Animals, 2019
Anticoagulant rodenticides are used to manage rodents in domestic, municipal, agricultural, and conservation settings. In mammals and birds, anticoagulant poisoning causes extensive hemorrhagic disruption, with the primary cause of death being severe ...
Penny Fisher, Karl J. Campbell, Gregg R. Howald, Bruce Warburton   +3 more
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First-In-Human Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of SHR2285, a Small-Molecule Factor XIa Inhibitor in Healthy Subjects

Frontiers in Pharmacology, 2022
Background: Targeting factor XI (FXI) is a promising therapeutic strategy for the treatment and prevention of thrombosis without increasing the risk of bleeding. Here, we assessed the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of SHR2285, a
Rui Chen, Xiaoduo Guan, Pei Hu, Yanli Dong, Yi Zhu, Tengfei Zhang, Jianjun Zou, Shuyang Zhang   +7 more
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Postmarketing surveillance on clinical use of edoxaban in patients with nonvalvular atrial fibrillation (ETNA‐AF‐Japan): Three‐month interim analysis results

Journal of Arrhythmia, 2019
Background Direct oral anticoagulants are the first‐line drugs for anticoagulation therapy in nonvalvular atrial fibrillation (NVAF). However, a real‐world, large‐scale, clinical study on edoxaban has not been performed.
Takeshi Yamashita, Yukihiro Koretsune, Mayumi Ishikawa, Kazuhito Shiosakai, Seiji Kogure   +4 more
doaj   +1 more source

A California Without Rodenticides: Challenges for Commensal Rodent Management in the Future

Human-Wildlife Interactions, 2019
Rodenticides are an essential tool in the integrated pest management of infestations of commensal rodents (Rattus norvegicus, R. rattus, and Mus musculus).
Niamh Quinn, Sylvia Kenmuir, Laura Krueger   +2 more
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Safety and preliminary efficacy of argatroban plus dual antiplatelet therapy for acute mild to moderate ischemic stroke with large artery atherosclerosis

Brain and Behavior, 2022
Objective Previous studies suggest the benefit of dual antiplatelet therapy (DAPT) for acute ischemic stroke with large artery atherosclerosis (LAA) etiology, but there is no study about the effect of DAPT plus anticoagulant in this population. Methods A
Xiao‐Qiu Li, Xiao‐Wen Hou, Yu Cui, Xiao‐Fu Tian, Xin‐Hong Wang, Zhong‐He Zhou, Hui‐Sheng Chen   +6 more
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A combination of bioflavonoid, oral thrombolytic and anticoagulant in the treatment of thrombophlebitis of varicose veins in outpatient surgical practice

Амбулаторная хирургия
Introduction. Comparability of the outcomes of treatment of patients with thrombophlebitis of varicose veins using surgical intervention and medical therapy, a wide range of drugs have become the basis for conducting this study.Aim.
E. P. Krivoshchekov, A. V. Poseryaev, M. Yu. Khoroshilov, V. E. Romanov, B. M. Rakhimov, A. V. Kazantsev, S. Zh. Kirgizbaev   +6 more
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Oral Anticoagulants in Women: What's the Difference? A Narrative Review

Clinical and Applied Thrombosis/Hemostasis
Gender sensitive medicine refers to the need to individualize epidemiology, diagnosis, knowledge of disease presentation, and therapy based also on sex and gender. An impressive amount of scientific literature deals now with sex and gender differences in
Elena Maria Faioni M.D, Barbara Scimeca M.D   +1 more
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