Results 71 to 80 of about 11,001 (169)
The Use of TRAUMAGEL® for Hemorrhage Control in a Complex Head Laceration: A Case Report
Open Access Emergency MedicineDavid Jay Kleiman,1 Tyler Nicholas Carruth,2 James Infanzon,1,3 Marvin E Nix,1,3 Brian J Goldstone3 1Cobb County Fire and Emergency Services, Marietta, GA, USA; 2Medical Affairs, Cresilon, Inc., Brooklyn, NY, USA; 3Department of Emergency Medicine ...
Kleiman DJ +4 more
doaj
Strategies to Overcome Heparins’ Low Oral Bioavailability
Pharmaceuticals, 2016 Even after a century, heparin is still the most effective anticoagulant available with few side effects. The poor oral absorption of heparins triggered the search for strategies to achieve oral bioavailability since this route has evident advantages over
Ana Rita Neves +3 more
doaj +1 more source
Advanced Science, EarlyView.The CXCL5/CXCR2 axis directly inhibits ferroptosis in ICC cells by activating the NF‐κB/PTGS2 pathway. Meanwhile, the CXCL5/CXCR2 axis recruits N2 TANs, and the activated PTGS2 promotes the secretion of TNF‐α from the recruited N2 TANs via the CCL2/CCL7/CCR2 pathway, thereby activating the NF‐κB/PTGS2 axis and forming a positive feedback loop, which ...
Chanqi Ye +17 more
wiley +1 more source
Advanced Science, EarlyView.Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke +10 more
wiley +1 more source
Advanced Science, EarlyView.An in situ dual‐mode platform integrates fusogenic liposomes with localized autocatalytic DNA circuits for plasma‐derived extracellular vesicle microRNA analysis. Following membrane fusion, target miRNAs trigger feedback‐assisted LECHA amplification inside intact vesicles, generating fluorescence and electrochemical outputs. Machine learning integrates
Wenbin Li +15 more
wiley +1 more source
Advanced Science, EarlyView.By merging centrifugal microfluidics, precise temperature control, and AI image recognition, T‐PhaseMap transforms biomolecular condensate phase mapping into a rapid, temperature‐resolved workflow. It generates 3D composition–temperature phase diagrams within 30 min, resolves four phase states, and uncovers temperature‐dependent heparin sodium ...
Jiashuo Li +6 more
wiley +1 more source
Editorial: Venous thromboembolism and pregnancy
Frontiers in Cardiovascular Medicine, 2022 Bernard Tardy, Laurent Bertoletti
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Advanced Science, EarlyView.A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung +15 more
wiley +1 more source
Indications and outcomes of rivaroxaban use in cats
Frontiers in Veterinary ScienceIntroductionThe use of rivaroxaban, an oral direct factor Xa inhibitor, has only been described in a small number of publications in cats. The study objective was to describe the use of rivaroxaban in a large population of hospitalised cats.MethodsCases ...
Ella Yarsley +6 more
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Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis
Advanced Science, EarlyView.CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan +13 more
wiley +1 more source