Results 161 to 170 of about 156,819 (199)

Anticoagulant activity and pleiotropic effects of heparin

JMV-Journal de Médecine Vasculaire, 2020
The recognized therapeutic effect of heparins is an anticoagulant activity (anti-Xa and anti-IIa) acting in an indirect manner (cofactor of antithrombin) but which is carried by only 20% at best of the glycan chains composing any commercial preparation of heparin, whether unfractionated or low molecular weight.
C, Bal Dit Sollier, J-G, Dillinger, L, Drouet   +2 more
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Synthesis of sulfated pectins and their anticoagulant activity

Biochemistry (Moscow), 2010
The following pectins were sulfated: bergenan BC (the pectin of Bergenia crassifolia L), lemnan LM (the pectin of Lemna minor L), and galacturonan as a backbone of pectins. Pyridine monomethyl sulfate, pyridine sulfotrioxide, and chlorosulfonic acid were used as reagents for sulfation.
F V, Vityazev, V V, Golovchenko, O A, Patova, N N, Drozd, V A, Makarov, A S, Shashkov, Yu S, Ovodov   +6 more
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Anticoagulant and antithrombin activities of oversulfated fucans

Carbohydrate Research, 1992
Three species of oversulfated fucans having different sulfate contents (the ratio of sulfate/total sugar residues, 1.38-1.98) were prepared by chemical sulfation of a fucan sulfate (sulfate/sugar ratio, 1.28) isolated from the brown seaweed Ecklonia kurome.
T, Nishino, T, Nagumo
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Effects of anticoagulants on protein C activity

Acta Cardiologica, 2019
Sir,We have read with great interest the article published by Stankovic et al. which was about association between plasma protein C level and myocardial necrosis and no-reflow phenomenon in patient...
Yusuf Ziya, Şener, Metin, Okşul, Seher, Şener   +2 more
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Antiatherosclerotic and Anticoagulant Activity of Cerebroside Sulfate

Japanese Heart Journal, 1961
(1) Oral administration of crude cerebroside extracted from bovine brain inhibited the diet-induced elevation of serum cholesterol in the rabbit. Both purified cerebroside and sphingomyelin showed similar and less effect. (2) Intravenously administered cerebroside and cerebroside sulfate proved to have hypocholesteremic effect. The latter significantly
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Antiplatelet, anticoagulant, and profibrinolytic activities of baicalin

Archives of Pharmacal Research, 2014
Baicalin is a flavonoid compound purified from the medicinal plant Scutellaria baicalensis Georgi and has been reported to possess anti-inflammatory and anti-viral activities. However, antiplatelet, anticoagulant, and profibrinolytic properties of baicalin have not been studied.
Wonhwa, Lee, Sae-Kwang, Ku, Jong-Sup, Bae   +2 more
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Bioengineered human heparin with anticoagulant activity

Metabolic Engineering, 2016
Heparin is a carbohydrate anticoagulant used clinically to prevent thrombosis, however impurities can limit its efficacy. Here we report the biosynthesis of heparin-like heparan sulfate via the recombinant expression of human serglycin in human cells. The expressed serglycin was also decorated with chondroitin/dermatan sulfate chains and the relative ...
Megan S, Lord, Bill, Cheng, Fengying, Tang, J Guy, Lyons, Jelena, Rnjak-Kovacina, John M, Whitelock   +5 more
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[The anticoagulant activity of fucoidans].

Eksperimental'naia i klinicheskaia farmakologiia, 1997
The influence of the degree of fucoidan macromolecules sulfation on their ability to induce an anticoagulant effect was studied. In in vitro experiments with the basic stain and in in vivo experiments on rabbits with performance of Quick's test, APTT, and spectrophotometric determination of antithrombin III (AT-III) activity a direct dependence of the ...
E A, Gavrilova, I I, Barbanova, A I, Usov, V S, Efimov, A I, Smirnov   +4 more
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Anticoagulant and antiheparin activities of a pentosan polysulphate

Thrombosis Research, 1983
Pentosan polysulphate (PPS, Hemoclar, MW 6,700) was observed to have a low affinity for ATIII-Sepharose eluting at 0.3M NaCl. Tested in vitro it had, as previously reported, a low potency as an anticoagulant, about 10 times less than heparin on a weight for weight basis.
M F, Scully, K M, Weerasinghe, V, Ellis, B, Djazaeri, V V, Kakkar   +4 more
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Anticoagulant Activity of Human Arterial Mucopolysaccharides

Nature, 1959
THE isolation of acid mucopolysaccharide material from human aortic tissue was reported in a previous publication1 from this laboratory. Analysis of the isolated material2 and of components separated by paper electrophoresis3,4 indicated that the major part of the material consisted of chondroitin sulphate.
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