Results 111 to 120 of about 187,275 (304)

Sertoli Cell‐Derived Extracellular Vesicles Orchestrate Cadmium‐Induced Testicular Inflammation and Fibrosis

open access: yesAdvanced Science, EarlyView.
Environmental cadmium exposure disrupts testicular homeostasis through a novel intercellular communication axis. Stressed Sertoli cells release extracellular vesicles carrying damage‐associated molecular patterns and mitochondrial fragments, which activate macrophages via TLR4/NF‐κB signaling.
Jianfeng Ma   +17 more
wiley   +1 more source

Syncope in Elderly People: A Threatening Presentation of Pulmonary Embolism: A Case Report [PDF]

open access: yes, 2015
age. Its prognosis is largely unpredictable, pending the origin of the sudden loss of consciousness. We report a case of an old woman affected by severe chronic heart failure, who died soon after the development of an episode of syncope, which was ...
Bilora, Franca   +3 more
core  

Transcriptomic and Neuroimaging Decoding of Brain‐Immune Crosstalk in Thyroid Eye Disease

open access: yesAdvanced Science, EarlyView.
This study employed an imaging transcriptomics framework integrating resting‐state fMRI with Allen Human Brain Atlas transcriptomic data, coupled with peripheral blood RNA sequencing, to decode brain‐immune crosstalk in thyroid eye disease. Frontal, parietal, subcortical, and brainstem regions were identified as key neuroimmune‐ vulnerable regions ...
Haiyang Zhang   +15 more
wiley   +1 more source

Non-valvular atrial fibrillation and stroke : implications for management [PDF]

open access: yes, 1995
Nonvalvular Atrial Fibrillation is more prevalent with increasing age. It is associated with a six-fold excess risk of stroke; and a cumulative lifetime stroke risk of 35%. 15% of ischaemic strokes are directly attributable to it.
Tilney, Myra Kay
core  

Mechanically Robust Biodegradable Stents With Theragenerative Vascular Responses via Combined 3D Printing and Janus Nanoengineering

open access: yesAdvanced Science, EarlyView.
This work introduces a theragenerative 3D‐printed biodegradable stent with Janus nanoarchitecture for spatially controlled vascular healing. A luminal tantalum ion–implanted surface accelerates endothelialization and hemocompatibility, while an abluminal sirolimus/poly‐L‐lactic acid–tantalum layer provides sustained drug release and suppresses smooth ...
Jong Hwa Seo   +19 more
wiley   +1 more source

Elevated Risk of Complications in Patients Receiving Dual Antithrombotic Therapy Undergoing Hepatectomy: A Single‐Center Audit of 749 Cases

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
This single‐center retrospective study evaluated perioperative outcomes after hepatectomy in 749 patients, including 140 receiving ATT, using propensity score matching to compare ATT and non‐ATT cohorts. Under standardized perioperative management, ATT did not increase major bleeding, transfusion, or severe morbidity overall; however, within the ATT ...
Haruki Mori   +9 more
wiley   +1 more source

Prognostic Significance of Portal Vein Tumor Thrombus in Pancreatic Ductal Adenocarcinoma Treated With Chemoradiotherapy

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim To examine the significance of portal vein tumor thrombus (PVTT) as a prognostic factor for patients with pancreatic ductal adenocarcinoma (PDAC) treated with chemoradiotherapy (CRT) followed by surgery. Methods The study retrospectively examined 313 patients with borderline resectable (BR) or locally advanced (LA) PDAC who underwent CRT ...
Aoi Hayasaki   +9 more
wiley   +1 more source

Reappraisal of Real‐World Management of Acute Cholecystitis in Elderly Patients Based on the Adherence to Tokyo Guidelines 2018 (TG18): A Multicenter Study on Anzu HPB Surgical Meeting

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
This multicenter retrospective study analyzes real‐world management of acute cholecystitis in patients aged ≥ 70 years across five institutions, focusing on adherence and intentional deviation from TG18 recommendations. By classifying treatment strategies as TG18‐accordant, more aggressive, or more conservative, we reappraise current practice patterns.
Yuta Kobayashi   +7 more
wiley   +1 more source

“Intrapericardial Approach” for Venous Outflow Reconstruction in Living‐Donor Liver Transplantation for Budd‐Chiari Syndrome: Surgical Techniques and LongTerm Outcomes

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
Unlike deceased‐donor liver transplantation, living‐donor liver transplantation (LDLT) for Budd‐Chiari Syndrome (BCS) presents distinctive challenges in hepatic venous (HV)‐outflow reconstruction because diseased HV–inferior vena cava (IVC) cannot be entirely replaced with healthy donor vessels.
Koichiro Hata   +4 more
wiley   +1 more source

Anticoagulant versus antiplatelet treatment for secondary stroke prevention in patients with active cancer

open access: yesFrontiers in Neurology
BackgroundApproximately 5–10% of patients with acute ischemic stroke (AIS) have known active cancer. These patients are at high risk for both recurrent AIS and major bleeding.
Moritz C. Kielkopf   +26 more
doaj   +1 more source

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