Results 111 to 120 of about 195,691 (306)

Syncope in Elderly People: A Threatening Presentation of Pulmonary Embolism: A Case Report [PDF]

, 2015
age. Its prognosis is largely unpredictable, pending the origin of the sudden loss of consciousness. We report a case of an old woman affected by severe chronic heart failure, who died soon after the development of an episode of syncope, which was ...
Bilora, Franca, Lucia, Sarolo, Pomerri, Fabio, Prandoni, Paolo   +3 more
core  

Mucin‐Inspired Filamentous Sulfated Copolymers Effectively Inhibit Human Respiratory Syncytial Virus (hRSV) Infectivity

Advanced Science, EarlyView.
Virucidal polymers serve as effective antivirals by not only inhibiting viruses but also destroying them. Inspired by the chemical properties of mucin‐mimetics, dendronized polyglycerol‐sulfated, mucin‐inspired amphiphilic copolymers (MIACPs) have been developed.
Raju Bej, Enyu Xie, Kai Ludwig, Robert F. Schmidt, Yannic Kerkhoff, Robert Dalgliesh, Nilanjan Paul, Michael Gradzielski, Andreas Herrmann, Christian Sieben, Rainer Haag   +10 more
wiley   +1 more source

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, EarlyView.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

Advanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang, Shaoju Jin, Shaoying Wen, Wen Zeng, Chen Wang, Jingyu Wang, Qingyun Song, Guizhong Li, Pengzhi Yin, Yuhui Liao, Yuee Chai, Huiping Zhang, Shengchao Ma   +12 more
wiley   +1 more source

Does aspirin have a role in preventing unprovoked recurrent thromboembolism?

Universa Medicina, 2015
Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), is a frequently recurring and serious complication after cessation of anticoagulant therapy.
Yenny Yenny
doaj   +1 more source

NIR Ratiometric Fluorescent Antibody‐Drug Conjugate for Metastatic Ovarian Cancer Theranostics and Treatment Response Monitoring

Advanced Science, EarlyView.
In vivo optical imaging enhances antibody‐drug conjugate (ADC) optimization by enabling real‐time monitoring of stimulus‐responsive drug behavior. We report n501‐CYMMAF, a ratiometric theranostic with strong target affinity and low‐dose efficacy for ovarian metastasis.
Cheng Li, Zezhong Yu, Tao Pu, Yanling Wu, Gang Wang, Youhua Xie, Tianlei Ying, Zhenlin Yang, Yibing Shi   +8 more
wiley   +1 more source

Anticoagulant versus antiplatelet treatment for secondary stroke prevention in patients with active cancer

Frontiers in Neurology
BackgroundApproximately 5–10% of patients with acute ischemic stroke (AIS) have known active cancer. These patients are at high risk for both recurrent AIS and major bleeding.
Moritz C. Kielkopf, Jayan Göcmen, Selina B. Venzin, Fabienne Steinauer, Mattia Branca, Anna Boronylo, Martina B. Göldlin, Johannes Kaesmacher, Adnan Mujanovic, Gianluca Costamagna, Gianluca Costamagna, Thomas R. Meinel, David J. Seiffge, Philipp Bücke, Mirjam R. Heldner, Ava L. Liberman, Hooman Kamel, Urs Fischer, Marcel Arnold, Thomas Pabst, Martin D. Berger, Simon Jung, Adrian Scutelnic, Babak B. Navi, Morin Beyeler, Morin Beyeler, Morin Beyeler   +26 more
doaj   +1 more source

Self-Inflicted Intraoral Hematoma in a Cardiac Patient Receiving Oral Anticoagulant Therapy- A Case Report [PDF]

Journal of Krishna Institute of Medical Sciences University, 2015
Intraoral hematoma secondary to systemic anticoagulant therapy is rare, but it is a potentially fatal condition requiring immediate medical management.
Shantala Arunkumar , Preethi A. Poonja, Shyam Amur, Atul P. Sattur , Krishna N. Burde, Venkatesh S Anehosur   +5 more
doaj  

Dual antithrombotic therapy with oral anticoagulant and P2Y12 inhibitors in patients with atrial fibrillation after percutaneous coronary intervention [PDF]

, 2023
Hideki Kitahara, Daichi Yamashita, Takanori Sato, Sakuramaru Suzuki, Takashi Hiraga, Tatsuro Yamazaki, Tadahiro Matsumoto, Takahiro Kobayashi, Yuji Ohno, Junya Harada, Kenichi Fukushima, Tatsuhiko Asano, Naoki Ishio, Raita Uchiyama, Hirofumi Miyahara, Shinichi Okino, Masanori Sano, Nehiro Kuriyama, Masashi Yamamoto, Naoya Sakamoto, Junji Kanda, Yoshio Kobayashi   +21 more
openalex   +1 more source

Design and implementation of a federated health record server [PDF]

, 2001
This paper describes the practical implementation of a federated health record serverbased on a generic and comprehensive public domain architecture and deployed in alive clinical setting.The authors, working at the Centre for Health Informatics and ...
Austin, A, Ingram, D, Kalra, D, Lloyd, D, O'Connor, A, Patterson, D   +5 more
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