Results 91 to 100 of about 143,207 (265)

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Role of direct oral anticoagulants in gastrointestinal cancerassociated thrombosis "gpractical issues in clinical practice"—narrative review

Objective: Direct oral anticoagulants (DOAC) are now considered an effective treatment option for cancer associated thrombosis (CAT). There are still controversies in the use of DOACs in CAT associated with gastrointestinal (GI) malignancies. Background:
Mahmood, Shahid, Yip, Desmond, Manoharan, Sathya, Jain, Ankit, Amira , Mohammad   +4 more
core   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

[Laboratory diagnostic with regard to new anticoagulants - monitoring and influence on coagulation tests]

, 2012
New oral anticoagulants promise to overcome essential drawbacks of traditional substances. They have a predictable therapeutic effect, a wide therapeutic window, only limited interaction with food and drugs and can be administered p.o. with a fixed dose.
Nagler, M, Wuillemin, W
core   +1 more source

Design and Engineering of an Artificial Bifunctional N‐Deacetylase/N‐Sulfotransferase for the Biosynthesis of N‐Sulfated Heparosan

Advanced Science, EarlyView.
An artificial bifunctional N‐deacetylase/N‐sulfotransferase was engineered in Escherichia coli by combining screened N‐deacetylases with an NST domain. The integrated engineering strategy improved enzyme performance. The optimized enzyme efficiently converted heparosan into N‐sulfated heparosan, addressing a key bottleneck in microbial heparin ...
Xintong Xi, Ruirui Xu, Daoan Wang, Guobin Yin, Xinjing Wang, Haiqin Chen, Guocheng Du, Jian Chen, Zhen Kang   +8 more
wiley   +1 more source

Surreptitious Ingestion of Oral Anticoagulants [PDF]

, 1970
Hypoprothrombinemia secondary to surreptitious ingestion of coumarin or indanedione anticoagulants may be a difficult diagnosis for the unsuspecting physician. Four such case reports are presented.
Van Slyck, Ellis J., Monto, Raymond W., Greidanus, Thomas H.   +2 more
core   +1 more source

A Dual‐Modal Wearable PPG Smartwatch with AI‐Enhanced Correction for High‐Accuracy and Continuous AF Burden Assessment

Advanced Science, EarlyView.
ABSTRACT Atrial fibrillation (AF) increases the risk of stroke and heart failure, yet accurate quantification of AF burden in daily life remains difficult. Although smartwatch photoplethysmography (PPG) supports continuous monitoring, complex rhythms and signal noise can impair burden estimation.
Song Zuo, Jinglei Wang, Xin Wang, Han Feng, Yize Zhao, Fadong Li, Shaobin Wei, Le Zhou, Zixu Zhao, Songjie Chen, Xiangyi Kong, Jue Wang, Liu He, Shijun Xia, Xin Li, Junmeng Zhang, Xiaoxia Liu, Xueyuan Guo, Ning Zhou, Songnan Li, Chenxi Jiang, Ribo Tang, Caihua Sang, Deyong Long, Xin Du, Jianzeng Dong, Wenwu Zhu, Changsheng Ma   +27 more
wiley   +1 more source

Modern Advances in Anticoagulant Therapy

, 2018
Thesis regarding the advances of anticoagulant therapy. This was a literature review which mainly focused on the trials on the Direct acting Oral Anticoagulants (DOACs).
Abdullah, Alend
core  

Modulating Calcium Homeostasis via a Biomimetic Scaffold to Rescue Diabetic Ischemic Wounds

Advanced Science, EarlyView.
This strategy addresses impaired microcirculation and loss of extracellular matrix (ECM) guidance in diabetic wound healing. Musc@CP, a nanofibrous dressing combining an ECM‐mimetic chitosan‐pullulan scaffold with muscone, enhances perfusion by attenuating intracellular Ca2+ overload‐associated endothelial dysfunction.
Xiang Zheng, Mingmei Li, Jianjun Jiang, Yongchao Wang, Yaru Jia, Weilun Sun, Yi Yao, Pengli Gao, Linhua Zhang, Qi Guo, Guang Jia, Xing‐Jie Liang, Dunwan Zhu, Jinchao Zhang, Fangzhou Li   +14 more
wiley   +1 more source

Comparative Analysis of Antithrombotic Therapy Outcomes in Mild Traumatic Brain-Injury Patients: A Focus on Bleeding Risk and Hospital-Stay Duration

Life
Background: Traumatic brain injury (TBI) in the elderly is a noteworthy pathology due to the exponential increase in population age, and the effects of antiplatelet and anticoagulation on patients’ outcomes are still a matter of dispute.
Antonio Desai, Dana Shiffer, Mauro Giordano, Alice Giotta Lucifero, Elena Generali, Francesco Reggiani, Marta Calatroni, Gabriele Savioli, Sabino Luzzi, Antonio Voza   +9 more
doaj   +1 more source