Results 101 to 110 of about 143,207 (265)

Direct oral anticoagulants: key considerations for use to prevent stroke in patients with nonvalvular atrial fibrillation

, 2015
Jerome Ment Department of Cardiology, Birmingham Heartlands Hospital, Birmingham, UK Abstract: Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide.
Ment J
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The preparation of patients taking anticoagulants for endoscopic procedures [PDF]

, 2016
Drugs that inhibit platelet aggregation and  anticoagulants are widely used in  primary and  secondary prevention of thromboembolism and treatment of venous thrombosis.
Poniewierka, Elżbieta, Robert Dudkowiak, Elżbieta Poniewierka, Negrusz-Kawecka, Marta, Smoliński, Rafał, Marta Negrusz-Kawecka, Dudkowiak, Robert, Rafał Smoliński   +7 more
core   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

Advanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv, Lei Zhang, Fei Fei, Zhibin Wu, Xiuquan Wu, Ya‐nan Dou, Yihao Fu, Hao Chang, Yujie Qiang, Huaxia Xie, Ni An, Leiying Chen, Hongchen Zhang, Min‐Wen Zheng, Hongqing Chen, Xia Li, Zhou Fei   +16 more
wiley   +1 more source

Sangramento durante a anticoagulação oral: alerta sobre um mal maior Sangrado durante la anticoagulación oral: alerta sobre un mal mayor Bleeding during oral anticoagulant therapy: warning against a greater hazard

Arquivos Brasileiros de Cardiologia, 2009
FUNDAMENTO: Sangramento é uma das grandes preocupações em pacientes sob anticoagulação oral. OBJETIVO: Investigar causas determinantes do sangramento em usuários de anticoagulante oral.
Paulo de Lara Lavítola, Guilherme Sobreira Spina, Roney Orismar Sampaio, Flávio Tarasoutchi, Max Grinberg   +4 more
doaj   +1 more source

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

Older patients with pulmonary embolism: a state-of-the-art review

Geriatric Care
Pulmonary embolism (PE) represents one of the main causes of acute respiratory failure in geriatric patients. In the older population, critical issues in PE management are multiple: reduced specificity of clinical signs and symptoms (with symptoms ...
Liliana Mazza, Mariagiovanna Cozza, Francesca Flavia Rossi, Roberto Caragnulo, Giulia Mussatti, Annalisa Paglia, Mattia Brunori, Vincenzo Gianturco, Andrea Rossi, Simone Dini   +9 more
doaj   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Limited evidence on persistence with anticoagulants, and its effect on the risk of recurrence of venous thromboembolism: a systematic review of observational studies [PDF]

, 2016
Pareen Vora, Montse Soriano-Gabarró, Kiliana Suzart, Gunnar Persson Brobert Department of Epidemiology, Bayer Pharma AG, Berlin, Germany Purpose: The risk of venous thromboembolism (VTE) recurrence is high following an initial VTE event, and it ...
Suzart K, Soriano-Gabarró M, Vora P, Persson Brobert G   +3 more
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Reversal of parenteral anticoagulants

, 2018
The most important adverse effect of antithrombotic treatment is the occurrence of bleeding. In case of severe bleeding in a patient who uses anticoagulant agents, or when a patient on anticoagulants needs to undergo an urgent invasive procedure, it may ...
Marcel Levi
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