Results 31 to 40 of about 269,235 (359)
Europace, 2018 The current manuscript is the Executive Summary of the second update to the original Practical Guide, published in 2013. Non-vitamin K antagonist oral anticoagulants (NOACs) are an alternative for vitamin K antagonists (VKAs) to prevent stroke in ...
J. Steffel +25 more
semanticscholar +1 more source
British Medical Bulletin, 2000 Anticoagulation is a treatment with significant and life threatening complications requiring that the balance of risk and benefit be individually assessed in each patient. The risks are greater in the elderly and those with hypertension, falls and gastrointestinal disease.
openaire +2 more sources
Pharmacogenetics of Anticoagulants [PDF]
Human Genomics and Proteomics, 2010 Warfarin, acenocoumarol, and phenprocoumon are among the major anticoagulant drugs worldwide. Because of their low therapeutic index and serious adverse reactions (ADRs), their wide use, and their varying kinetics and pharmacogenetic dependence, it is of great importance to explore further possibilities to forecast the dose beyond conventional INR ...
Anders Rane, Jonatan D. Lindh
openaire +3 more sources
Effectiveness and Safety of Oral Anticoagulants Among Nonvalvular Atrial Fibrillation Patients
Stroke, 2018 Background and Purpose— This ARISTOPHANES study (Anticoagulants for Reduction in Stroke: Observational Pooled Analysis on Health Outcomes and Experience of Patients) used multiple data sources to compare stroke/systemic embolism (SE) and major bleeding ...
G. Lip +12 more
semanticscholar +1 more source
New anticoagulants: Moving beyond the direct oral anticoagulants
Journal of Thrombosis and Haemostasis, 2020 Although anticoagulants have been in use for more than 80 years, heparin and vitamin K antagonists were the sole available options until recently. Although these agents revolutionized the prevention and treatment of thrombotic diseases, their use has ...
J. Fredenburgh, J. Weitz
semanticscholar +1 more source
TH Open, 2020 SARS-CoV-2 infection (COVID-19) results in local and systemic activation of inflammation and coagulation. In this review article, we will discuss the potential role of coagulation factor Xa (FXa) in the pathophysiology of COVID-19. FXa, a serine protease,
Galit H. Frydman +3 more
doaj +1 more source
Medicina, 2021 Pregnancy and the postpartum period represent a condition characterized by a thrombotic predisposition. The majority of pregnant women do not face acute or severe thrombotic events.
Catalina Filip +5 more
doaj +1 more source
Digestive Endoscopy, 2018 In 2012, the Japan Gastroenterological Endoscopy Society published “Guidelines for Gastroenterological Endoscopy in Patients Undergoing Antithrombotic Treatment” concerning thromboembolism associated with antithrombotic therapy withdrawal.
Mototsugu Kato +6 more
semanticscholar +1 more source
Oral anticoagulants: Optimizing venous thromboembolism management
Journal of Applied Hematology, 2019 A decade ago, oral anticoagulants were limited to Vitamin K antagonists, i.e., warfarin. Since 2010, the US Food and Drug Administration has approved several non-Vitamin K oral anticoagulants: dabigatran is a direct thrombin inhibitor, while apixaban ...
Fahad A S. Aleidan
doaj +1 more source
Review of Medical Therapies for the Management of Pulmonary Embolism
Medicina, 2021 Traditionally, the management of patients with pulmonary embolism has been accomplished with anticoagulant treatment with parenteral heparins and oral vitamin K antagonists.
Ladan Panahi +7 more
doaj +1 more source