Results 81 to 90 of about 48,636 (289)
Advanced Science, EarlyView.This study introduces KK2DP7, a dendrimer‐structured peptide adjuvant, as a tool to decode trained immunity's role in antitumor therapy. Splenic CD11b+ cells mediate tumor suppression via TLR2‐IRF7 activation and epigenetic reprogramming, validated by adoptive transfer experiments.
Rui Zhang +5 more
wiley +1 more source
Clinical Cardiology, Volume 45, Issue 12, Page 1255-1263, December 2022., 2022 Abstract Background The definitive treatment for chronic thromboembolic pulmonary hypertension (CTEPH) is pulmonary endarterectomy (PEA), which has good long‐term outcomes. However, after surgery, a quarter of the patients still have residual pulmonary hypertension (RPH). In pulmonary hemodynamics, there are no unified criteria for RPH, even though the
Wu Song +4 more
wiley +1 more source
Online Learning to Estimate Warfarin Dose with Contextual Linear Bandits [PDF]
arXiv, 2019 Warfarin is one of the most commonly used oral blood anticoagulant agent in the world, the proper dose of Warfarin is difficult to establish not only because it is substantially variant among patients, but also adverse even severe consequences of taking an incorrect dose.
arxiv
Medicine, 2000 Abstract Anticoagulation prevents pathological clot formation (e.g. on heart valves or chambers) and stops propagation and embolization of clots already developed in veins. The type, intensity and duration of anticoagulation depend on the indication. About 1.8% of the UK population requires anticoagulation. The two main anticoagulant drugs are heparin
openaire +2 more sources
Advanced Science, EarlyView.This study develops an Au/S‐doped reduced graphene oxide (Au@S‐rGO) sensor for rapid fentanyl detection. DFT simulations and structural analysis confirm atomically dispersed Au/S configurations, enhancing catalytic activity. The sensor achieves a 9.7 nmol L−1 detection limit, 98–104% recovery in human serum, and 85.7–93.6% consistency with mass ...
Meng Li +9 more
wiley +1 more source
Clinical Cardiology, Volume 45, Issue 12, Page 1211-1219, December 2022., 2022 Abstract Background Elderly patients with ST‐elevation myocardial infarction (STEMI) who undergo percutaneous coronary intervention (PCI) are usually excluded from major trials. Hyopthesis This study sought to assess 1‐year clinical outcomes following PCI with a drug‐eluting stent in patients older than 80 years old with STEMI.
Majdi Saada +11 more
wiley +1 more source
Advanced Science, EarlyView.This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua +19 more
wiley +1 more source
Analysis of atherosclerotic plaque distribution in the carotid artery
Clinical Cardiology, Volume 45, Issue 12, Page 1272-1276, December 2022., 2022 Abstract Background The present study was designed to investigate the hypothesis that the outer wall at the carotid bifurcation is the most common area of atherosclerotic plaque deposition due to the low shear stress. Hypothesis We hypothesized that the most common site of arteriosclerosis in carotid arteries is different in the early and late stages ...
Shin‐Seok Yang +2 more
wiley +1 more source
New classification‐oriented treatment strategy for portal vein thrombosis after hepatectomy
Annals of Gastroenterological Surgery, 2020 Aim This study sought to evaluate the incidence, risk factors, and clinical outcomes of portal vein thrombosis after hepatectomy. Furthermore, we proposed a novel classification and treatment strategy for portal vein thrombosis after hepatectomy. Methods
Shinji Onda +9 more
doaj +1 more source
Advanced Science, EarlyView.A universal and versatile zwitterion coating strategy is developed for blood‐contacting catheters with long lengths and complex geometries. The coating exhibits near‐zero fouling, superior anticoagulation, and selective biocapturing properties while maintaining excellent stability under dynamic blood flow.
Tong Zhang +6 more
wiley +1 more source