Results 191 to 200 of about 72,257 (246)

Multicultural clinical interactions: the importance of the Explanatory Model (EM) concept in understanding the cultural dimensions of clinical practice [PDF]

, 2011
Bassett, AM
core  

Alkalinised lidocaine as an anaesthetic before onabotulinumtoxinA injections. a randomised trial

BJU International, Volume 135, Issue 4, Page 638-647, April 2025.
Objectives To evaluate the effect of intravesical alkalinised lidocaine as an anaesthetic treatment on procedural pain during intradetrusor onabotulinumtoxinA (BTX‐A) injections for overactive bladder. Patients and Methods This single‐centre, randomised, double‐blind, placebo‐controlled two period crossover trial was conducted on women scheduled for ...
Meryam El Issaoui, Marlene Elmelund, Niels Klarskov   +2 more
wiley   +1 more source

Glycyrrhizin as a potential disease-modifying therapy for epilepsy: insights into targeting pyroptosis to exert neuroprotective and anticonvulsant effects. [PDF]

Front Pharmacol
Wei L, Ou S, Meng Y, Sun L, Zhang L, Lu Y, Wu Y.   +6 more
europepmc   +1 more source

Progress on the development of Class A GPCR‐biased ligands

British Journal of Pharmacology, EarlyView.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales, Magdalena M. Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K. Hansen, Nadine Jagerovic, Jan Jakubík, György M. Keserű, Dóra Judit Kiss, Pawel Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo‐Abreu, Gemma Navarro, Rubén Prieto‐Díaz, Mette M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, Laura M. Wingler   +20 more
wiley   +1 more source

Anticonvulsant Profiles of Three Hemorphin-4 Analogs with Rhodamine B in Mice. [PDF]

Pharmaceuticals (Basel)
Tchekalarova J, Rangelov M, Iliev I, Todorova N, Stoyanova T, Nedelchev L, Todorov P.   +6 more
europepmc   +1 more source

Cannabidiol dose dependently reduces alcohol intake in mice via a non‐5‐HT1A receptor mechanism: Exploration of other potential receptor targets

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Binge drinking is a risky pattern of alcohol intake and a major predictor of alcohol use disorder (AUD). Current AUD medications have limited efficacy and poor patient compliance, calling for more effective therapeutics.
Connie J. Badolato, Erin A. Lynch, Jonathon C. Arnold, Iain S. McGregor, Michael T. Bowen   +4 more
wiley   +1 more source

Stereocontrolled synthesis of 3-hydroxy-2-piperidinone carboxamides by catalytic ring-opening aminolysis of bridged <i>δ</i>-lactam-γ-lactones. [PDF]

RSC Adv
Beng TK, Curry K, Gitonga A, Yu K, Edwards S.   +4 more
europepmc   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

A Novel Compound QO-83 Alleviates Acute and Chronic Epileptic Seizures in Rodents by Modulating K_V7 Channel Activity. [PDF]

CNS Neurosci Ther
Wang X, Zhang Y, Liu H, Wang J, Zhang B, He T, Zhang H, Xiong Z, Liu X, Li J, Zhao W, Liu X, Zhang W, Yang L, Li Q, Zhang H, Qi J, Jia Q.   +17 more
europepmc   +1 more source

A comprehensive review of the neurological effects of anethole. [PDF]

IBRO Neurosci Rep
Khodadadian R, Balali-Dehkordi S.
europepmc   +1 more source