Results 171 to 180 of about 47,981 (309)

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

<i>E/Z</i> Isomerism of the Potential Antiepileptic Drug GIZH-298. [PDF]

Molecules
Mokrov GV, Litvinova SA, Biryukova VE, Voronina TA, Shorunov SV, Rebeko AG, Vorobyova TY, Grushevskaya LN, Sergeeva MS, Kuznetsov DN, Kravtsova OY, Nikitina EA, Gladysheva NA, Zhanataev AK, Durnev AD, Losev TV, Malashkeevich KM, Medvedev MG, Islamov MM, Lyssenko KA, Dorofeev VL.   +20 more
europepmc   +1 more source

Epilepsy surgery: From bench to the clinics

Epilepsia Open, EarlyView.
Abstract Objective Recent advances in epilepsy surgery in patients with intractable epilepsy make it possible to study the mechanism of epilepsy in human brains. However, the true extent and propagation of each epileptogenic area from the epileptogenic focus in each patient is still difficult to perform “epilepsy cure” by surgery.
Tatsuya Tanaka
wiley   +1 more source

High Doses of Melatonin Induce Seizure-like Cortical Activity: Electrophysiological and Behavioral Evidence. [PDF]

ACS Omega
Almeida L, Lins A, Eiró-Quirino L, de Souza LV, Hamoy MKO, Hartcoff PFP, Brito MVDS, Barbosa GB, Reis TS, Hamoy M.   +9 more
europepmc   +1 more source

Perampanel as add‐on in high‐grade glioma–related epilepsy: Seizure control and QoL in a prospective, multicenter, real‐world 6‐month follow‐up study

Epilepsia Open, EarlyView.
Abstract Objective High‐grade astrocytomas, including glioblastomas, are aggressive brain tumors with poor prognosis and a 5‐year survival below 7%. Seizures affect up to 75% of glioma patients, especially in low‐grade tumors but also in high‐grade cases.
Matteo Impellizzeri, Paolo Paone, Giada Pauletto, Annacarmen Nilo, Simone Beretta, Andrea Salmaggi, Stefano Consoli, Stefano Quadri   +7 more
wiley   +1 more source

Design, synthesis, and in vivo antiepileptic evaluation of novel quinazolinone-phthalimide derivatives. [PDF]

Sci Rep
Moradkhani F, Asadi M, Dehpour AR, Amini M, Amanlou M.   +4 more
europepmc   +1 more source

A first in disease trial of the safety, tolerability, and anti‐seizure effects of ES‐481 in drug‐resistant epilepsy

Epilepsia Open, EarlyView.
Abstract Objectives ES‐481 is a novel potent and selective antagonist of TARP‐y8‐dependent AMPA receptors. We aimed to assess the potential efficacy, safety and tolerability, and pharmacokinetics of different doses of ES‐481 as an add‐on anti‐seizure medication (ASM) in adults with drug‐resistant epilepsy (DRE). Methods This was a Phase 2A double‐blind,
Emma C. Foster, Lyn Millist, Jack Germaine, Stephanie Chamorro, Caitlin Roberts, John‐Paul Nicolo, Sean Hosking, Piero Perucca, Saul Mullen, Heather Robinson, Rebecca Wharrie, Brittany Walsh, David Reutens, Kimberley Irwin, Hao Zeng, Robert Niecestro, Terence J. O'Brien   +16 more
wiley   +1 more source

<i>Caenorhabditis</i> Intervention Testing Program: the anticonvulsant levetiracetam does not extend lifespan in nematodes. [PDF]

MicroPubl Biol
Akella JS, Onken BD, Sedore CA, Song Y, Achanta VM, Walker M, Xue J, Guo S, Coleman-Hulbert A, Phillips PC, Lithgow GJ, Driscoll M.   +11 more
europepmc   +1 more source

Phytochemicals and Health Benefits of American Ginseng (Panax quinquefolius L.): Current Knowledge and Future Perspectives

Food Safety and Health, EarlyView.
This review summarizes the chemical constituents and functional characteristics of American ginseng, aiming to provide references for its development and application. ABSTRACT American ginseng, a perennial herbaceous plant, is recognized for its significant medicinal properties and has attracted considerable attention due to its diverse phytochemical ...
Wei Geng, Ning Zhou, Jinqian Yu, Yanling Geng, Xiao Wang, Yannan Chen   +5 more
wiley   +1 more source

"Adverse event reports of seizure for insomnia medication from 1967 to 2023". The challenge of using hypnotic medication in people with epilepsy. [PDF]

Front Neurol
Di Mauro G, Liguori C.
europepmc   +1 more source