Results 201 to 210 of about 88,387 (345)

Dextromethorphan versus Dextrorphan: A Quantitative Comparison of Antitussive Potency following Separate Administration of Metabolite

The Journal of Clinical Pharmacology, EarlyView.
Abstract To assess the antitussive effects of dextrorphan (DOR) relative to its parent compound, dextromethorphan (DEX) a double‐blind, randomized, placebo‐controlled crossover study was conducted in 23 healthy volunteers using citric acid cough challenge test after administering placebo, DEX, or DOR.
Saeed Rezaee, Caroline E. Wright, Alyn H. Morice, Amin Rostami‐Hodjegan   +3 more
wiley   +1 more source

Multistage Molecular Simulations, Design, Synthesis, and Anticonvulsant Evaluation of 2-(Isoindolin-2-yl) Esters of Aromatic Amino Acids Targeting GABA_A Receptors via π-π Stacking. [PDF]

Int J Mol Sci
González-Periañez S, Hernández-Rosas F, López-Rosas CA, Ramos-Morales FR, Zurutuza-Lorméndez JI, García-Rodríguez RV, Olivares-Romero JL, Ramos-Hernández RR, Bravo-Espinoza I, Vidal-Limon A, Pawar TJ.   +10 more
europepmc   +1 more source

Congenital Abnormalities and Anticonvulsant Drugs

, 1970
S R Meadow
openalex   +1 more source

Serum anticonvulsant monitoring by liquid chromatography with a methanolic mobile phase. [PDF]

, 1979
David J. Freeman, N Rawal
openalex   +1 more source

Clinical Evaluation of Drug–Drug Interactions Between Bictegravir and Strong Inhibitors/Inducers of the CYP3A4, UGT1A1, or P‐gp Pathways

The Journal of Clinical Pharmacology, EarlyView.
Abstract In addition to antiretroviral therapy (ART), people with HIV often take medications to treat comorbidities. It is therefore important to assess these medications for potential drug‐drug interactions, which may affect the safety and efficacy of ART. Three phase I studies were conducted in adult participants without HIV. The pharmacokinetics (PK)
Priyanka Arora, Hui Liu, John Ling, Jason T. Hindman, Dhananjay D. Marathe   +4 more
wiley   +1 more source

Involvement of GABA/BDZ receptors in the anticonvulsant effects of dihydrosanguinarine from <i>Bocconia arborea</i> S. Watson. [PDF]

Heliyon
González-Gómez JD, Estrada-Soto S, Gaona-Tovar E, González-Trujano ME, Villasana-Salazar B, Narváez-González HF, Martínez-Vargas D.   +6 more
europepmc   +1 more source

Effect of anticonvulsant therapy on serum 25-hydroxyvitamin D level.

, 1978
Kiyoomi Sumi, Takahiro Sugita, Tsunesuke Shimotsuji, Yoshiki Seino, Takashi Mimaki, Hyakuji Yabuuchi   +5 more
openalex   +2 more sources

Prognosis in childhood epilepsy: A follow-up study of 148 cases in which therapy had been suspended after prolonged anticonvulsant control [PDF]

, 1971
Jean Holowach, Don L. Thurston, James L. O′Leary   +2 more
openalex   +1 more source

Establishing a Quantitative Framework for Combined Oral Contraceptives: Evaluating the Impact of Drug–Drug Interactions on Exposure and Clinical (Surrogate) Efficacy Endpoints

The Journal of Clinical Pharmacology, EarlyView.
Abstract According to the FDA Guidance for Industry on Clinical Drug Interaction (DDI) Studies with Combined Oral Contraceptives (COCs), sponsors are expected to conduct dedicated clinical DDI studies if in vitro findings suggest weak or moderate CYP3A induction, while concomitant use of COCs with strong inducers should be avoided. The guidance further
Dain Chun, Huili Chen, Brian Cicali, Serge Guzy, Joachim Hoechel, Tianze Jiao, Valvanera Vozmediano, Stephan Schmidt   +7 more
wiley   +1 more source

Correction: Chen et al. Metabolomics-Based Study on the Anticonvulsant Mechanism of <i>Acorus tatarinowii</i>: GABA Transaminase Inhibition Alleviates PTZ-Induced Epilepsy in Rats. <i>Metabolites</i> 2025, <i>15</i>, 175. [PDF]

Metabolites
Chen L, Li J, Fang C, Wang J.
europepmc   +1 more source