Results 221 to 230 of about 53,577 (300)

Natural product‐derived TRPM7 channel inhibitors in neurological injury: Mechanisms, pharmacological potential and translational challenges

British Journal of Pharmacology, EarlyView.
Disruption of intracellular ionic homeostasis is a convergent pathological feature across diverse neurological injuries and disorders, including ischaemic and haemorrhagic stroke, hypoxic–ischaemic brain injury, traumatic brain injury, epilepsy and brain tumour.
Xinyang Zhang, Hio Lam Ho, F. David Horgen, Andrea Fleig, Zhong‐Ping Feng, Hong‐Shuo Sun   +5 more
wiley   +1 more source

GLP‐1 receptor activation attenuates chronic migraine‐like behaviour: Sex‐specific modulation of opioid‐ and endocannabinoid‐related pathways

British Journal of Pharmacology, EarlyView.
Background and Purpose Chronic migraine (CM) is a highly disabling condition that remains suboptimally treated. Metabolic disturbances may trigger migraine chronification, whereas impaired endogenous pain inhibition contributes to CM development. Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), used for type 2 diabetes and obesity, show efficacy ...
Katarina Sićović, Katarina Nastić, Miroslav Dinić, Emilija Brdarić, Uroš Pecikoza, Maja Tomić, Ana Micov   +6 more
wiley   +1 more source

Effects of Valproate and Deferoxamine on Epileptiform Activity, Oxidative Stress, and Nitric Oxide in a Penicillin-Induced Epilepsy Model. [PDF]

Biology (Basel)
Çetindağ A, Özsoy Ş, Hacisüleyman L, Çakir Z, Delibaş EAÖ.   +4 more
europepmc   +1 more source

Mental health hospitalisations of care‐experienced and general‐population children with chronic conditions: evidence from the Children's Health in Care in Scotland (CHiCS) study, a population‐wide longitudinal study using administrative data

Child and Adolescent Mental Health, EarlyView.
Background Care experience and chronic physical conditions in children are associated with an increased risk of mental health (MH) problems. These issues can compound, leading to poorer prognosis for both MH and chronic conditions. Examining the relationship between care experience and mental ill‐health, and exploring how chronic conditions may ...
Edit Gedeon, Alastair H. Leyland, Marion Henderson, Mirjam Allik   +3 more
wiley   +1 more source

Plant-derived Natural Products in Neurological and Psychiatric Disorders: Mechanisms of Action and Synergistic Roles with Probiotics. [PDF]

Mol Neurobiol
Shokr MM, Abu-Elsaoud AM, Al Raish SM.
europepmc   +1 more source

Lung Cancer Brain Metastasis: Brain Microenvironmental Adaptation, Therapeutic Resistance and Translational Strategies

Cancer Science, EarlyView.
Lung cancer brain metastasis is shaped by dynamic crosstalk among tumor cells, the blood–brain barrier, glial and immune cells, neurons, and metabolic niches. This review integrates these mechanisms with therapeutic resistance, translational models, CNS delivery, and multidisciplinary treatment strategies.
Jun Yang, Junyi Xiong, Li Ying, Yanyang Zeng, Ziqiang Ouyang, Mei Liu, Meihua Li   +6 more
wiley   +1 more source

Pharmacological Switching in Minor Phytocannabinoids: A Mechanistic Framework for Compound-Indication Matching and Precision Neurotherapeutic Development. [PDF]

Pharmaceuticals (Basel)
Bagher AM.
europepmc   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

The Discovery of Cenobamate: A Drug with High Efficacy in Drug-Resistant Epilepsy. [PDF]

CNS Drugs
Choi YM, White HS, Klein P, Löscher W.
europepmc   +1 more source

The Accuracy of Frozen Section Histopathology in the Rapid Diagnosis of Severe Cutaneous Adverse Reactions: A Systematic Review and Meta‐Analysis

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Frozen section analysis enables rapid diagnosis, but its diagnostic accuracy in the setting of severe cutaneous adverse reactions (SCARs) remains poorly defined. Methods A systematic review and meta‐analysis were performed to evaluate the diagnostic performance of frozen sections in the rapid identification of SCARs, with a focus on
Cody C. Frear, Louise Frear, Duncan Lambie, Amanda Godbolt   +3 more
wiley   +1 more source