Results 231 to 240 of about 84,044 (310)

Thiazole-Bearing 4-Thiazolidinones as New Anticonvulsant Agents

open access: yesScientia Pharmaceutica, 2020
Here, we describe the synthesis and anticonvulsant activity of thiazole-bearing hybrids based on 2-imino-4-thiazolidinone and 2,4-dioxothiazolidine-5-carboxylic acid cores.
Danylo Kaminskyy   +2 more
exaly   +2 more sources
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Cannabichromene, Related Phytocannabinoids, and 5-Fluoro-cannabichromene Have Anticonvulsant Properties in a Mouse Model of Dravet Syndrome.

ACS Chemical Neuroscience, 2021
Cannabis-based products are increasingly being used to treat refractory childhood epilepsies such as Dravet syndrome. Cannabis contains at least 140 terpenophenolic compounds known as phytocannabinoids.
L. Anderson   +6 more
semanticscholar   +1 more source

Anticonvulsant mechanisms of piperine, a piperidine alkaloid

open access: yesChannels, 2015
Piperine, a natural compound isolated from the fruits of Piper, is known to modulate several neurotransmitter systems such as serotonin, norepinephrine, and GABA, all of which have been linked to the development of convulsions.
Awanish Mishra   +2 more
exaly   +2 more sources

Quinazolines: New horizons in anticonvulsant therapy

European Journal of Medicinal Chemistry, 2014
Sanjay Bari
exaly   +2 more sources

Anticonvulsants in migraine

Current Pain and Headache Reports, 2004
Migraine is a common, disabling disorder that often requires preventive treatment. The decision to treat migraine preventively generally is based on disability, problems with acute medicines, patient preference, risk of acute medication overuse, special circumstances, and concern that high migraine attack frequency may be a risk factor for chronic ...
William B, Young   +2 more
openaire   +2 more sources

Anticonvulsants and Busulfan

Annals of Internal Medicine, 1990
Excerpt To the Editor:Two recent letters (1, 2) described the use of anticonvulsants to prevent seizures secondary to high-dose busulfan therapy as a preparative regimen for bone marrow transplanta...
W E, Fitzsimmons, R, Ghalie, H, Kaizer
openaire   +2 more sources

Intraction of the Anticonvulsant Ameltolide with standard Anticonvulsants

Epilepsia, 1992
Summary: The newly characterized anticonvulsant ameltolide was studied in mice in combination with the standard antiepileptic drugs (AEDs), phenytoin (PHT), carbamazepine (CBZ), and valproate (VPA). In combination with either PHT or CBZ, ameltolide produced dose‐ additive effects in the maximal electroshock (MES) lest and in the horizontal screen (HS)
openaire   +2 more sources

Developments in anticonvulsants

1995
Epilepsy is one of the oldest of common human ailments and is mentioned in ancient writings such as the Babylonian Code of Hammurabi 2080 BC and in the Hebrew scriptures. Its clinical description was given by Hippocrates in his monograph (ca. 400 BC) on the disease [1]. In earlier times the paroxysmal, uncontrollable behaviour of epileptics was thought
A K, Saxena, M, Saxena
openaire   +2 more sources

Synthesis and anticonvulsant activity of new phenytoin derivatives

European Journal of Medicinal Chemistry, 2013
Nadia Abdalla, Yara El-Dash
exaly   +2 more sources

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