Results 231 to 240 of about 47,218 (298)

PBPK Modeling: Empowering Drug Development and Precision Dosing in China

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling, a cornerstone of model‐informed drug development and model‐informed precision dosing, simulates drug disposition in the human body by integrating physiological, biochemical, and physicochemical parameters.
Dongsheng Yang, Jian Li, Wen Yao Mak, Aole Zheng, Xiao Zhu, Qingfeng He, Yuzhu Wang, Xiaoqiang Xiang   +7 more
wiley   +1 more source

Discovery of a potent, Kv7.3-selective potassium channel opener from a Polynesian traditional botanical anticonvulsant. [PDF]

Commun Chem
Abbott GW, Manville RW.
europepmc   +1 more source

A Comprehensive Review on the Influence of Menstrual Cycle and Pregnancy on Epileptic Seizures. [PDF]

Cureus
Kolomar H, Osman A, Arias Blanco LV, Ali Alotaibi F, Flores Del Valle IL, Mohammed SF, Singh S, Algitagi F, Marroquín León E.   +8 more
europepmc   +1 more source

Mimosa pudica L. aqueous extract protects mice against pilocarpine-picrotoxin kindling-induced temporal lobe epilepsy, oxidative stress, and alteration in GABAergic/cholinergic pathways and BDNF expression. [PDF]

Front Pharmacol
Mambou HMAY, Pale S, Bopda OSM, Jugha VT, Musa NSO, Ojongnkpot TA, Wanyu BY, Bila RB, Herqash RN, Shahat AA, Taiwe GS.   +10 more
europepmc   +1 more source

Oral morphine used to control intensive pain in a dog (canis familiaris) with tonsil carcinoma, and metastasis in medial retropharyngeal lymph node

Veterinary Record Case Reports, EarlyView.
Abstract An 11‐year‐old, female West Highland white terrier presenting cough, emesis, diarrhoea and hyporexia refractory to symptomatic treatment was subjected to endoscopy showing increased palatine tonsil region. Biopsy findings revealed a carcinoma. Computed tomography also showed an increased right medial retropharyngeal lymph node dorsally related
Jiuli R. S. de Salles, Andressa F. K. Thomaz de Lima, Camila Squarzoni Dale   +2 more
wiley   +1 more source

Metabolomics-Based Study on the Anticonvulsant Mechanism of <i>Acorus tatarinowii</i>: GABA Transaminase Inhibition Alleviates PTZ-Induced Epilepsy in Rats. [PDF]

Metabolites
Chen L, Li J, Fang C, Wang J.
europepmc   +1 more source

Treatment and outcome of gall bladder leiomyoma in an asymptomatic dog

Veterinary Record Case Reports, EarlyView.
Abstract The purpose of this report was to describe the diagnostic protocol, treatment and outcome of an 11‐year‐old, entire male, mixed‐breed dog with a gall bladder neoplasia histologically consistent with a leiomyoma. On referral, the patient had no clinical signs related to the gall bladder mass.
Elisa Pizzi, Stefano Zanardi, Andrea Renzi, Ilaria Maga, Sara Del Magno   +4 more
wiley   +1 more source

Vestibular epilepsy associated with a temporoparietal lobe meningioma in a cat. [PDF]

J Vet Intern Med
Peters RK.
europepmc   +1 more source

Cenobamate, a New Promising Antiseizure Medication: Experimental and Clinical Aspects. [PDF]

Int J Mol Sci
Błaszczyk B, Czuczwar SJ, Miziak B.
europepmc   +1 more source

Preventing Infant Mortality Through Medicaid‐Administered Prenatal Care Coordination: Evidence From Wisconsin

Health Services Research, EarlyView.
ABSTRACT Objective To estimate associations between Wisconsin Medicaid's Prenatal Care Coordination (PNCC) program and infant mortality. Data Sources and Study Setting We analyzed birth records, Medicaid claims, and infant death records for all resident and in‐state Medicaid‐paid live deliveries during 2010–2018.
David C. Mallinson, Yamikani B. Nkhoma‐Mussa, Kate H. Gillespie, Roger L. Brown   +3 more
wiley   +1 more source