The Pharmacology and Toxicology of Third-Generation Anticonvulsant Drugs. [PDF]
J Med Toxicol, 2017 LaPenna P, Tormoehlen LM.
europepmc +2 more sources
Neuropeptides as targets for the development of anticonvulsant drugs. [PDF]
Mol Neurobiol, 2014 Epilepsy is a common neurological disorder characterized by recurrent seizures. These seizures are due to abnormal excessive and synchronous neuronal activity in the brain caused by a disruption of the delicate balance between excitation and inhibition ...
Clynen E +4 more
europepmc +2 more sources
Function of inhibitory micronetworks is spared by Na+ channel-acting anticonvulsant drugs. [PDF]
J Neurosci, 2014 The mechanisms of action of many CNS drugs have been studied extensively on the level of their target proteins, but the effects of these compounds on the level of complex CNS networks that are composed of different types of excitatory and inhibitory ...
Pothmann L +8 more
europepmc +2 more sources
Psilocin, A Psychedelic Drug, Exerts Anticonvulsant Effects Against PTZ- and MES-Induced Seizures in Mice via 5-HT1A and CB1 Receptors: Involvement of Nitrergic, Opioidergic, and Kynurenine Pathways. [PDF]
Pharmacol Res PerspectBalabandian M +9 more
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Targeting the Ghrelin Receptor as a Novel Therapeutic Option for Epilepsy
Biomedicines, 2021 Epilepsy is a neurological disease affecting more than 50 million individuals worldwide. Notwithstanding the availability of a broad array of antiseizure drugs (ASDs), 30% of patients suffer from pharmacoresistant epilepsy.
An Buckinx +3 more
doaj +1 more source
Brain Sciences, 2022 Approximately 30% of epileptic patients develop Drug-Resistant Epilepsy. Based on evidence that shows a loss of efficacy in some sodium channel blocker antiseizure drugs in epilepsy, we focus our study on assessing the anticonvulsant efficacy of ...
Cecilia Zavala-Tecuapetla +3 more
doaj +1 more source
WITHDRAWN. Anticonvulsant drugs for acute and chronic pain. [PDF]
Cochrane Database Syst Rev, 2010 BACKGROUND Anticonvulsant drugs have been used in the management of pain since the 1960s. The clinical impression is that they are useful for chronic neuropathic pain, especially when the pain is lancinating or burning.
Wiffen PJ +5 more
europepmc +3 more sources
A 14-year-old female with fever, rash, lymphadenopathy, and pancytopenia: a case report
Journal of Medical Case Reports, 2020 Background Anticonvulsant hypersensitivity syndrome is a rare adverse drug reaction associated with aromatic anticonvulsant drugs. This syndrome can range from mild cutaneous rash to drug reaction with eosinophilia and systemic symptoms that include ...
Mojtaba Varshochi +5 more
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Searching for New Leads to Treat Epilepsy: Target-Based Virtual Screening for the Discovery of Anticonvulsant Agents [PDF]
, 2018 The purpose of this investigation is to contribute to the development of new anticonvulsant drugs to treat patients with refractory epilepsy. We applied a virtual screening protocol that involved the search into molecular databases of new compounds and ...
Bruno Blanch, Luis Enrique +8 more
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Эпилепсия и пароксизмальные состояния, 2019 Aim. This study was aimed to test the instrumental complex called «Bioscope» for its ability to determine the optimal dose of the anticonvulsant drugs lamotrigine and topiramate in the treatment of epileptiform states.Materials and methods.
R. G. Paronikyan +7 more
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