Results 191 to 200 of about 3,750,719 (375)

Neuroprotective Efficacy of Microwave‐Assisted Synthetized 2‐(5‐Cyclopropyl‐6‐Thioxo‐1,3,5‐Thiadiazinan‐3‐Yl) Acetic Acid in Mitigating Cognitive Deficits in Pentylenetetrazole‐Induced Mice Model

open access: yesChemistryOpen, EarlyView.
Microwave synthesis yielded 2‐(5‐cyclopropyl‐6‐thioxo‐1,3,5‐thiadiazinan‐3‐yl)acetic acid, confirmed by infrared, nuclear magnetic resonance, and electron ionization mass spectrometry. In a pentylenetetrazole‐induced epilepsy model, it countered oxidative stress by boosting antioxidant enzymes (catalase, peroxidase, superoxide dismutase, glutathione ...
Tahir Iqbal   +9 more
wiley   +1 more source

Evaluation of the Antifungal Properties of Azomethine‐Pyrazole Derivatives from a Structural Perspective

open access: yesChemistryOpen, EarlyView.
A series of azomethine‐pyrazole derivatives bearing a para‐substituted azo‐phenyl ring is straightforwardly prepared. The new compounds display an elevated antifungal activity against various Candida species and Cryptococcus neoformans strains. DFT and molecular docking calculations are used to determine possible routes of action through interactions ...
María Isabel Murillo   +8 more
wiley   +1 more source

Distinct gene expression responses of two anticonvulsant drugs in a novel human embryonic stem cell based neural differentiation assay protocol [PDF]

open access: green, 2014
Sjors H.W. Schulpen   +4 more
openalex   +1 more source

Voltammmetric Assessment and Examination of the Interactions between Levetiracetam and DNA: Experimental Research, Molecular Docking, and Modeling Studies

open access: yesChemistryOpen, EarlyView.
This research introduces, for the first time, a novel, efficient, cost‐effective, and highly sensitive approach for the quantification of levetiracetam (LEV) through a differential pulse voltammetry technique based on its interaction with DNA. The method capitalizes on the changes observed in the oxidation current peak of the deoxyguanosine base, which
Abdullah Al Faysal   +3 more
wiley   +1 more source

Polymer type effect on microparticle blend of ethyl cellulose, poly(lactic‐co‐glycolic acid) and poly(ε‐caprolactone) for controlled drug delivery with varying solubility

open access: yesPolymer International, EarlyView.
Preparation, possible microparticles formed, morphology of microparticles and drug release profile from polymeric microparticles. Abstract The objective of this study was to investigate the impact of polymer type on polymeric microparticle blends designed for controlled drug delivery. Microparticle blends containing a single drug (propranolol HCl [Pro]
Muhaimin Muhaimin, Roland Bodmeier
wiley   +1 more source

Low‐value interventions to deimplement: A secondary analysis of a systematic review of low back pain clinical practice guidelines

open access: yesPM&R, EarlyView.
Abstract Objective To perform a secondary review of low back pain (LBP) clinical practice guidelines (CPG) identified in a recently conducted systematic review and to synthesize and summarize low‐value recommendations as practices that may be candidates for deimplementation.
Daniel Tai   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy