Results 281 to 290 of about 3,750,719 (375)

In vitro Assessment of Drug Adsorption Profiles during Hemoadsorption Therapy.

Blood Purif
Körtge A, Kamper C, Klinkmann G, Wasserkort R, Mitzner S.   +4 more
europepmc   +1 more source

Molecular mechanisms of neuroprotective effect of rutin. [PDF]

Front Pharmacol
Chunmei Z, Shuai W.
europepmc   +1 more source

Diffusion imaging shows microstructural alterations in untreated, non‐lesional patients already after a first unprovoked seizure

Epilepsia, Volume 66, Issue 3, Page 833-846, March 2025.
Abstract Objective Patients with newly diagnosed epilepsy exhibit brain white matter (WM) abnormalities, but the temporal dynamics of these are unknown. The literature suggests these alterations might be present before diagnosis. This study investigates WM microstructural integrity using diffusion imaging in non‐lesional (NL), interictal epileptiform ...
Marysol Segovia‐Oropeza, Erik Hans Ulrich Rauf, Ev‐Christin Heide, Niels K. Focke   +3 more
wiley   +1 more source

Bridging the conversational gap in epilepsy: Using large language models to reveal insights into patient behavior and concerns from online discussions

Epilepsia, Volume 66, Issue 3, Page 686-699, March 2025.
Abstract Objective This study was undertaken to explore the experiences and concerns of people living with epilepsy by analyzing discussions in an online epilepsy community, using large language models (LLMs) to identify themes, demographic patterns, and associations with emotional distress, substance use, and suicidal ideation.
Uriel Fennig, Elad Yom‐Tov, Leehe Savitzky, Johnatan Nissan, Keren Altman, Roni Loebenstein, Marina Boxer, Nitai Weinberg, Shany Guly Gofrit, Nicola Maggio   +9 more
wiley   +1 more source

EEG signal dimension is an index of seizure propensity and antiseizure medication effects in a mouse model of acquired epilepsy

Epilepsia, EarlyView.
Abstract Objective Variability in the frequency, timing, and pattern of seizures may influence the assessment of the effect of antiseizure medications (ASMs) when measuring seizure frequency, especially in patients with infrequent seizures. A low seizure rate is an exclusion criterion for enrollment of patients with epilepsy in clinical trials and ...
Massimo Rizzi, Peter J. West, Annamaria Vezzani, Karen S. Wilcox, Alessandro Giuliani   +4 more
wiley   +1 more source

Continuous video recording with simultaneous amplitude-integrated EEG monitoring to improve seizure recognition in newborns. [PDF]

Front Pediatr
Kage A, Santana YC, Malcolm IL, Francia C, Yoong M, Wertheim D, Shah D.   +6 more
europepmc   +1 more source

kcnb1 loss of function in zebrafish causes neurodevelopmental and epileptic disorders associated with γ‐aminobutyric acid dysregulation

Epilepsia, EarlyView.
Abstract Objective KCNB1 encodes an α‐subunit of the delayed‐rectifier voltage‐dependent potassium channel Kv2.1. De novo pathogenic variants of KCNB1 have been linked to developmental and epileptic encephalopathies (DEEs), diagnosed in early childhood and sharing limited treatment options.
Lauralee Robichon, Claire Bar, Anca Marian, Lisa Lehmann, Solène Renault, Edor Kabashi, Sorana Ciura, Rima Nabbout   +7 more
wiley   +1 more source

Ivermectin as a promising therapeutic option for onchocerciasis-associated epilepsy. [PDF]

Epilepsia Open
Manavi MA, Mohammad Jafari R, Shafaroodi H, Sharifzadeh M, Dehpour AR.   +4 more
europepmc   +1 more source

The human photosensitive epilepsy model for clinical proof‐of‐principle trials of novel antiseizure medications: 2. Analysis of drug trials and predictive value of the model

Epilepsia, EarlyView.
Abstract Clinical development of novel antiseizure medications (ASMs) would benefit from an early proof of principle (POP) model. The photosensitivity model, which uses the photoparoxysmal electroencephalographic response (PPR) as a surrogate of seizures, is currently the only human model that allows POP trials of investigational compounds after a ...
Wolfgang Löscher, Dorothée Kasteleijn‐Nolst Trenité   +1 more
wiley   +1 more source

Anticonvulsant Profiles of Three Hemorphin-4 Analogs with Rhodamine B in Mice. [PDF]

Pharmaceuticals (Basel)
Tchekalarova J, Rangelov M, Iliev I, Todorova N, Stoyanova T, Nedelchev L, Todorov P.   +6 more
europepmc   +1 more source