Results 41 to 50 of about 3,750,719 (375)

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica, Devin K. Binder, Meinrad Drexel, Chrysanthy Ikonomidou, Shilpa D. Kadam, Guenther Sperk, Christian Steinhäuser   +6 more
wiley   +1 more source

Anticonvulsant Activity of Halogen-Substituted Cinnamic Acid Derivatives and Their Effects on Glycosylation of PTZ-Induced Chronic Epilepsy in Mice

Molecules, 2017
Epilepsy is a common chronic neurological disorder disease, and there is an urgent need for the development of novel anticonvulsant drugs. In this study, the anticonvulsant activities and neurotoxicity of 12 cinnamic acid derivatives substituted by ...
Ye Cuan, Xirui He, Yuhui Zhao, Jiajun Yang, Yajun Bai, Yin Sun, Qiang Zhang, Zefeng Zhao, Xiaoyang Wei, Xiaohui Zheng   +9 more
doaj   +1 more source

A companion to the preclinical common data elements for phenotyping seizures and epilepsy in rodent models. A report of the TASK3‐WG1C: Phenotyping working group of the ILAE/AES joint translational task force

Epilepsia Open, EarlyView., 2022
Abstract Epilepsy is a heterogeneous disorder characterized by spontaneous seizures and behavioral comorbidities. The underlying mechanisms of seizures and epilepsy across various syndromes lead to diverse clinical presentation and features. Similarly, animal models of epilepsy arise from numerous dissimilar inciting events.
Melissa Barker‐Haliski, Julika Pitsch, Aristea S. Galanopoulou, Rüdiger Köhling   +3 more
wiley   +1 more source

Design, synthesis, molecular docking and anticonvulsant evaluation of novel 6-iodo-2-phenyl-3-substituted-quinazolin-4(3H)-ones

Bulletin of Faculty of Pharmacy Cairo University, 2015
A new series of 6-iodo-2-phenyl-3-substituted-quinazolin-4(3H)-one (5–12a–b) derivatives were synthesized, evaluated for their anticonvulsant activity against pentylenetetrazole (PTZ)-induced seizures and maximal electroshock test and compared with the ...
Mohamed-Kamal Ibrahim, Khaled El-Adl, Ahmed A. Al-Karmalawy   +2 more
doaj   +1 more source

The opposite effect of convulsant drugs on neuronal and endothelial nitric oxide synthase – A possible explanation for the dual proconvulsive/anticonvulsive action of nitric oxide

Acta Pharmaceutica, 2023
Nitric oxide (NO) participates in processes such as endothelium-dependent vasodilation and neurotransmission/neuromodulation. The role of NO in epilepsy is controversial, attributing it to anticonvulsant but also proconvulsant properties.
Vega Rasgado Lourdes A., Ramón-Gallegos Eva, Rodríguez-Páez Lorena, Alcántara-Farfán Verónica   +3 more
doaj   +1 more source

Assessing neurotropic effects of new antiepileptic nitrogen-containing drugs

Эпилепсия и пароксизмальные состояния, 2023
Objective: to evaluate an effectiveness of new nitrogen-containing compounds for alleviating epileptiform conditions in animal experimental study, and conduct molecular modeling of a new neurotropic drug.Material and methods.
R. G. Paronikyan, G. G. Avakyan, V. N. Avakyan, E. G. Paronikyan   +3 more
doaj   +1 more source

The Anticonvulsant Effect of Hydroethanolic Leaf Extract of Calotropis procera (Ait) R. Br. (Apocynaceae)

Neural Plasticity, 2021
A number of currently used drugs have been obtained from medicinal plants which are a major source of drugs. These drugs are either used in their pure form or modified to a semisynthetic drug.
Ernest Obese, Robert Peter Biney, Isaac Tabiri Henneh, Emmanuel Awintiig Adakudugu, Daniel Anokwah, Lovia Serwaa Agyemang, Eric Woode, Elvis Ofori Ameyaw   +7 more
doaj   +1 more source

Tonic Clonic Status Epilepticus

Pediatric Neurology Briefs, 1993
The phases of status epilepticus and management with anticonvulsant drugs are reviewed from the Institute of Neurology, National Hospital, Queen Square, London.
J Gordon Millichap
doaj   +1 more source

Evaluation of Anticonvulsant Activity of 80% Methanolic Root Bark Extract and Solvent Fractions of Pentas schimperiana (A. Rich.) Vatke (Rubiaceae) in Swiss Albino Mice

Advances in Pharmacological and Pharmaceutical Sciences, 2021
Background. Epilepsy is one of the most common serious neurological disorders, responsible for substantial morbidity and mortality due to limited efficacy and negative properties of antiepileptic drugs.
Nebeyi Fisseha, Workineh Shibeshi, Daniel Bisrat   +2 more
doaj   +1 more source

Practical considerations in the pharmacological treatment of bipolar disorder

Sichuan jingshen weisheng, 2023
Bipolar disorder is one of the most common mood disorders characterized by an early age of onset and high prevalence rate， and patients tent to have poor prognosis due to high misdiagnosis rate and incomplete diagnosis rate.
Liu Tiebang
doaj   +1 more source