Results 41 to 50 of about 3,859,657 (248)
Neural Plasticity, 2021 A number of currently used drugs have been obtained from medicinal plants which are a major source of drugs. These drugs are either used in their pure form or modified to a semisynthetic drug.
Ernest Obese +7 more
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How Can Network-Pharmacology Contribute to Antiepileptic Drug Development? [PDF]
, 2014 Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant magic bullet paradigm which proposed the search of exquisitely selective drugs. What is
Di Ianni, Mauricio Emiliano +1 more
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Neuropeptide receptors as potential antiepileptic drug targets : focus on the ghrelin axis [PDF]
, 2014 Epilepsy is a very serious neurological disorder which is often underrepresented. Around 50 million individuals worldwide have active epilepsy with recurrent seizures and in spite of the medical advances over the years, 30% of these patients remain as ...
Portelli, Jeanelle
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Arquivos de Neuro-Psiquiatria, 1995 We studied retrospectively 894 adult epileptic patients treated during the period from 1983 to 1992. Hepatic enzymes abnormal values were seen in 49%(n=438). In 22.3%(n=200), at least 2 enzyme levels in different moments were altered.
Mauricio Hoshino +4 more
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Advances in Pharmacological and Pharmaceutical Sciences, 2021 Background. Epilepsy is one of the most common serious neurological disorders, responsible for substantial morbidity and mortality due to limited efficacy and negative properties of antiepileptic drugs.
Nebeyi Fisseha +2 more
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Tonic Clonic Status Epilepticus
Pediatric Neurology Briefs, 1993 The phases of status epilepticus and management with anticonvulsant drugs are reviewed from the Institute of Neurology, National Hospital, Queen Square, London.
J Gordon Millichap
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Acute and long-term effects of brivaracetam and brivaracetam-diazepam combinations in an experimental model of status epilepticus. [PDF]
, 2017 ObjectiveTo evaluate acute and long-term effects of intravenous brivaracetam (BRV) and BRV + diazepam (DZP) combination treatment in a rat model of self-sustaining status epilepticus (SSSE).MethodsRats were treated with BRV (10 mg/kg) 10 min after ...
Alldredge +32 more
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Design, synthesis and evaluation of benzofuran-acetamide scaffold as potential anticonvulsant agent
Acta Pharmaceutica, 2016 A series of N-(2-(benzoyl/4-chlorobenzoyl)-benzofuran- 3-yl)-2-(substituted)-acetamide derivatives (4a-l, 5a-l) was synthesized in good yield. All synthesized compounds were in agreement with elemental and spectral data.
Shakya Ashok K. +6 more
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Molecules, 2017 Some novel fluorinated quinazolines (5a–j) were designed and synthesized to be evaluated for their anticonvulsant activity and their neurotoxicity. Structures of all newly synthesized compounds were confirmed by their infrared (IR), mass spectrometry (MS)
Mohamed F. Zayed +5 more
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Impaired biotin status in anticonvulsant therapy [PDF]
, 1982 In 264 epileptics undergoing long-term therapy with anticonvulsants, significantly reduced plasma biotin levels were found compared with a normal control group: 74% of the epileptics had biotin levels for those treated with sodium valproate were higher ...
Bonjour +7 more
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