Results 51 to 60 of about 3,750,719 (375)
Advanced Sensor Research, EarlyView.The illustration showcases resonant optical microsensors for Doxorubicin (DXR) detection, using polystyrene sulfonate (PSS) as a synthetic receptor. PSS is deposited as a nanometer‐thick layer on fluorescent microparticles via layer‐by‐layer assembly. DXR‐PSS interaction is depicted, highlighting its effect on the sensor's resonant modes.
Elena Maurina +4 more
wiley +1 more source
How Can Network-Pharmacology Contribute to Antiepileptic Drug Development? [PDF]
, 2014 Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant magic bullet paradigm which proposed the search of exquisitely selective drugs. What is
Di Ianni, Mauricio Emiliano +1 more
core +1 more source
The 4-Aminopyridine Model of Acute Seizures in vitro Elucidates Efficacy of New Antiepileptic Drugs [PDF]
, 2019 Up to date, preclinical screening for new antiepileptic substances is performed by a combination of different in vivo models of acute seizures, for which large numbers of animals are necessary.
Dag, Ramazan +4 more
core +1 more source
Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine
Advanced Science, EarlyView.Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang +4 more
wiley +1 more source
Advanced Science, EarlyView.The study develops a H•/H– transfer strategy enabling efficient hydrocyclization/defluorination of CF3‐acrylamides to synthesize Seletracetam derivatives with gem‐difluoroalkenes. Mechanistic studies reveal distinct pathways: the NiII‐H/PhSiH3 system operates through a hydrogen atom transfer process, while the 1,4‐Michael addition of H– appears to be ...
Yanjun Wan, Ronghui Shao, Jack R. Norton
wiley +1 more source
Nano‐Anesthetics Regulate Neuro‐Immune Interaction for Treating Neuropathic Pain
Advanced Science, EarlyView.Ce‐UiO‐66‐Bupivacaine (CUB) demonstrates triple therapeutic innovation: 1) Sustained analgesia with ROS scavenging synergistically resolves neuropathic pain; 2) Microglia/astrocyte polarization switch reprograms the pro‐regenerative immune microenvironment; 3) CGRP‐TSP‐1 axis activation couples inflammation suppression to axon regeneration, defining a ...
Yue Wang +9 more
wiley +1 more source
Molecules, 2022 Seizures and epilepsy are some of the most common serious neurological disorders, with approximately 80% of patients living in developing/underdeveloped countries. However, about one in three patients do not respond to currently available pharmacological
Fábio Rodrigues de Oliveira +7 more
doaj +1 more source
Enaminone‐Based Push–Pull Chromophores: Synthesis, Optical Properties, and Computational Insights
Asian Journal of Organic Chemistry, EarlyView.Enaminones, known for their pharmacophoric properties, were combined with alkyne units to create complex chromophore structures through click‐type [2 + 2] cycloaddition‐retroelectrocyclization reactions. The ICT characteristics of the synthesized compounds were analyzed using both experimental and computational approaches.
Mehmet Mart +2 more
wiley +1 more source
Molecules, 2017 Some novel fluorinated quinazolines (5a–j) were designed and synthesized to be evaluated for their anticonvulsant activity and their neurotoxicity. Structures of all newly synthesized compounds were confirmed by their infrared (IR), mass spectrometry (MS)
Mohamed F. Zayed +5 more
doaj +1 more source
Animal models of cisplatin‐induced neuropathic pain
Animal Models and Experimental Medicine, EarlyView.This article illustrates the modeling process of a cisplatin‐induced neuropathic pain model in rats or mice. Multiple modeling tests are required for rats or mice before, during, and after modeling. The appropriate injection method, dose, and modeling method are selected, and multiple assays are chosen for evaluation and comparison.
Ningxin Li +9 more
wiley +1 more source