Results 51 to 60 of about 3,859,657 (248)

Preliminary Anticonvulsant and Toxicity Screening of Substituted Benzylidenehydrazinyl-N-(6-substituted benzo[d]thiazol-2-yl)propanamides

The Scientific World Journal, 2014
Keeping in view the structural requirements suggested in the pharmacophore model for anticonvulsant activity, a new series of 3-(2-(substitutedbenzylidene)hydrazinyl)-N-(substituted benzo[d]thiazol-2-yl)-propanamides were synthesized with aromatic ...
Ruhi Ali, Nadeem Siddiqui
doaj   +1 more source

Teratogenic effects of gabapentin on the skeletal system of Balb/C mice fetuses [PDF]

, 2009
Objectives: To evaluate the effects of gabapentin )GBP( administration on mice fetuses. Methods: This study was carried out in Birjand University of Medical Sciences during 2008.
Afshar, M., Golalipour, M.J., Hassanzadeh-Taheri, M.M., Moallem, S.-A., Tamizi, A.   +4 more
core  

Metabolic perturbations associated with the consumption of a ketogenic medium-chain TAG diet in dogs with idiopathic epilepsy [PDF]

, 2018
Consumption of diets containing medium-chain TAG (MCT) has been shown to confer neuroprotective effects. We aim to identify the global metabolic perturbations associated with consumption of a ketogenic diet (medium-chain TAG diet (MCTD)) in dogs with ...
Benjamini, Brian Zanghi, Elizabeth J. Want, Geyelin, Hill, Holger A. Volk, Isaac, Law, Patterson, Tsz Hong Law, Yuanlong Pan   +10 more
core   +2 more sources

Experimental study of the anticonvulsant and psychotropic activities of pufemid, pyrathidine, and compound N3212 as compared with reference anti-epileptic drugs

Эпилепсия и пароксизмальные состояния, 2019
Aim: to study the anticonvulsant and psychotropic activities and side effects of pufemid, pyrathidine and compound N3012 developed at the Institute of Fine Organic Chemistry of the National Academy of Sciences.Materials and methods.
R. G. Paronikyan, M. N. Avagyan, A. A. Harutyunyan, G. G. Avakyan, S. A. Litvinova, T. A. Voronina   +5 more
doaj   +1 more source

An Exploratory Analysis of Pharmaceutical Price Disparities and Their Implications Among Six Developed Nations [PDF]

, 2006
In our study of 43 drugs, prescription drug prices in several wealthy nations (Australia, Canada, France, Germany, and the U.K.) were much lower than in the U.S. on average, well below relative per capita GDP. There was relatively little difference among
Elizabeth DuPre, John E. Calfee, Mario Villarreal   +2 more
core  

The voltage-sensing domain of kv7.2 channels as a molecular target for epilepsy-causing mutations and anticonvulsants

Frontiers in Pharmacology, 2011
Understanding the molecular mechanisms underlying voltage-dependent gating in voltage-gated ion channels (VGICs) has been a major effort over the last decades. In recent years, changes in the gating process have emerged as common denominators for several
Francesco eMiceli, MariaVirginia eSoldovieri, Fabio Arturo Iannotti, Vincenzo eBarrese, Paolo eAmbrosino, Maria eMartire, Maria Roberta Cilio, Maurizio eTaglialatela, Maurizio eTaglialatela   +8 more
doaj   +1 more source

Lithium Prescribing during Pregnancy: A UK Primary Care Database Study [PDF]

, 2015
Women taking lithium must decide whether to continue the medication if they conceive or plan to conceive.
Cowen, PJ, Evans, SJ, McCrea, RL, Nazareth, I, Osborn, DP, Petersen, I, Pinfold, V   +6 more
core   +2 more sources

Cannabinoids in the treatment of epilepsy: current status and future prospects [PDF]

, 2020
Cannabidiol (CBD) is one of the prominent phytocannabinoids found in Cannabis sativa, differentiating from Δ9-tetrahydrocannabinol (THC) for its non-intoxicating profile and its antianxiety/antipsychotic effects.
Albini M., Cifelli P., Di Bonaventura C., Fanella M., Giallonardo A. T., Morano A., Palma E.   +6 more
core   +1 more source

Recent developments on triazole nucleus in anticonvulsant compounds: a review

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Epilepsy is one of the common diseases seriously threatening life and health of human. More than 50 million people are suffering from this condition and anticonvulsant agents are the main treatment.
Ming-Xia Song, Xian-Qing Deng
doaj   +1 more source

Hybridization of the effective pharmacophores for treatment of epilepsy: design, synthesis, in vivo anticonvulsant activity, and in silico studies of phenoxyphenyl-1,3,4-oxadiazole-thio-N-phenylacetamid hybrids

BMC Chemistry, 2023
Background Epilepsy is a common neurological disorder. The available drugs for this disease only control convulsions in nearly 70% of patients, while bearing many side effects.
Azadeh Fakhrioliaei, Fahimeh Abedinifar, Pedram Salehi Darjani, Maryam Mohammadi-Khanaposhtani, Bagher Larijani, Nematollah Ahangar, Mohammad Mahdavi   +6 more
doaj   +1 more source