Results 61 to 70 of about 3,750,719 (375)

The voltage-sensing domain of kv7.2 channels as a molecular target for epilepsy-causing mutations and anticonvulsants

Frontiers in Pharmacology, 2011
Understanding the molecular mechanisms underlying voltage-dependent gating in voltage-gated ion channels (VGICs) has been a major effort over the last decades. In recent years, changes in the gating process have emerged as common denominators for several
Francesco eMiceli, MariaVirginia eSoldovieri, Fabio Arturo Iannotti, Vincenzo eBarrese, Paolo eAmbrosino, Maria eMartire, Maria Roberta Cilio, Maurizio eTaglialatela, Maurizio eTaglialatela   +8 more
doaj   +1 more source

Design, synthesis and evaluation of benzofuran-acetamide scaffold as potential anticonvulsant agent

Acta Pharmaceutica, 2016
A series of N-(2-(benzoyl/4-chlorobenzoyl)-benzofuran- 3-yl)-2-(substituted)-acetamide derivatives (4a-l, 5a-l) was synthesized in good yield. All synthesized compounds were in agreement with elemental and spectral data.
Shakya Ashok K., Kamal Mehnaz, Balaramnavar Vishal M., Bardaweel Sanna K., Naik Rajashri R., Saxena Anil K., Siddiqui H. H.   +6 more
doaj   +1 more source

Hybridization of the effective pharmacophores for treatment of epilepsy: design, synthesis, in vivo anticonvulsant activity, and in silico studies of phenoxyphenyl-1,3,4-oxadiazole-thio-N-phenylacetamid hybrids

BMC Chemistry, 2023
Background Epilepsy is a common neurological disorder. The available drugs for this disease only control convulsions in nearly 70% of patients, while bearing many side effects.
Azadeh Fakhrioliaei, Fahimeh Abedinifar, Pedram Salehi Darjani, Maryam Mohammadi-Khanaposhtani, Bagher Larijani, Nematollah Ahangar, Mohammad Mahdavi   +6 more
doaj   +1 more source

Posterior Reversible Encephalopathy Syndrome and Azathioprine [PDF]

, 2019
Posterior reversible encephalopathy syndrome (PRES) is a rare syndrome that presents with neurological manifestations, often associated with arterial hypertension.
Corte-Real, A, Vilas-Boas, S
core   +2 more sources

New Insights into Cannabis Consumption; Abuses and Possible Therapeutic Effects [PDF]

, 2015
Cannabis is one of the oldest psychotropic drugs known to humanity. The paper assesses the current knowledge on the cannabis, including the mechanisms of action and the therapeutic potential of cannabinoids.
Baconi, Daniela Luiza, Bălălău, Cristian, Vasile, Robert Daniel   +2 more
core   +8 more sources

Visible Light‐Mediated Preparation of a Key Intermediate Employed in the Synthesis of Zolpidem and Several Analogs

Chemistry – An Asian Journal, EarlyView.
A new visible light‐induced method is reported for the C3‐alkylation of imidazo[1,2‐a]pyrimidines and ‐pyridines with aryldiazoacetates. This protocol can be performed in open air and serves as a convenient entry to several known and new molecules. A formal synthesis of zolpidem is achieved by changing the alkylating agent to an appropriate hypervalent
Ronei M. S. Souza, Tales A. C. Goulart, Roberto do C. Pinheiro, Felipe F. do C. Sonaglio, Deborah de A. Simoni, Rodrigo A. Cormanich, Igor D. Jurberg   +6 more
wiley   +1 more source

Preliminary Anticonvulsant and Toxicity Screening of Substituted Benzylidenehydrazinyl-N-(6-substituted benzo[d]thiazol-2-yl)propanamides

The Scientific World Journal, 2014
Keeping in view the structural requirements suggested in the pharmacophore model for anticonvulsant activity, a new series of 3-(2-(substitutedbenzylidene)hydrazinyl)-N-(substituted benzo[d]thiazol-2-yl)-propanamides were synthesized with aromatic ...
Ruhi Ali, Nadeem Siddiqui
doaj   +1 more source

Evaluation of Anticonvulsant Activity of Dual COX-2/5-LOX Inhibitor Darbufelon and Its Novel Analogues

Scientia Pharmaceutica, 2021
Neuroinflammation is an integral part of epilepsy pathogenesis and other convulsive conditions, and non-steroidal anti-inflammatory drugs (NSAIDs) present a potent tool for the contemporary search and design of novel anticonvulsants. In the present paper,
Mariia Mishchenko, Sergiy Shtrygol’, Andrii Lozynskyi, Semen Khomyak, Volodymyr Novikov, Olexandr Karpenko, Serhii Holota, Roman Lesyk   +7 more
doaj   +1 more source

A randomised trial of a medium-chain TAG diet as treatment for dogs with idiopathic epilepsy [PDF]

, 2015
Despite appropriate antiepileptic drug treatment, approximately one-third of humans and dogs with epilepsy continue experiencing seizures, emphasising the importance for new treatment strategies to improve the quality of life of people or dogs with ...
Brian Zanghi, Dahlin, Elizabeth Want, Emma S. S. Davies, Engel, Geyelin, Holger A. Volk, Lowrie, Masino, Patterson, Piotr, Piotr, Schwartz, Schwartz-Porsche, Thigpen, Tsz Hong Law, Wilder, Yuanlong Pan   +17 more
core   +3 more sources

Synthesis, Characterization, Biological Properties, and Sensor Applications of Novel Thiosemicarbazone Derivatives

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT In this study, novel thiosemicarbazone derivative molecules (5a–j) were synthesized. The characterization of the synthesized molecules was carried out using 1H–, 13C–NMR, FT–IR, and Q–TOF spectroscopic techniques. Then, the inhibitory effect of these compounds was examined for human carbonic anhydrase I and II (hCA I, and II) and ...
Hayreddin Gezegen, Oguz Özbek, Meryem Topal, Hatice Şahin, Ümit M. Koçyiğit   +4 more
wiley   +1 more source