Results 131 to 140 of about 105,937 (401)

Urolithiasis associated with topiramate

International Brazilian Journal of Urology, 2004
OBJECTIVE: Topiramate is a sulfamate-substituted monosaccharide anticonvulsant used as adjunctive therapy for intractable refractory seizures. It is report a case of topiramate-induced urolithiasis.
Scott Eggener, Samuel C. Kim, Herbert M. User, Joseph Pazona, Robert B. Nadler   +4 more
doaj   +1 more source

The effectiveness of anticonvulsants in psychiatric disorders

Dialogues in Clinical Neuroscience, 2008
Anticonvulsant drugs are widely used in psychiatric indications. These include mainly alcohol and benzodiazepine withdrawal syndromes, panic and anxiety disorders, dementia, schizophrenia, affective disorders, bipolar affective disorders in particular ...
H. Grunze
semanticscholar   +1 more source

Isoniazid‐Dihydropyrimidinone Molecular Hybrids: Design, Synthesis, Antitubercular Activity, and Cytotoxicity Investigations with Computational Validation

ChemMedChem, EarlyView.
Antitubercular evaluation of a novel library of isoniazid‐dihydropyrimidinone molecular hybrids (8a–8n) discloses a potent compound with MIC = 0.39μg mL−1 against M. tuberculosis mc26230. Cytotoxicity, stability, and in silico studies, including molecular docking and ADME/T (absorption, distribution, metabolism, excretion, and toxicity) analysis ...
Gobind Kumar, Pule Seboletswe, Sahil Mishra, Neha Manhas, Safiyah Ghumran, Nagaraju Kerru, Françoise Roquet‐Banères, Maëlle Foubert, Laurent Kremer, Gaurav Bhargava, Parvesh Singh   +10 more
wiley   +1 more source

Further SAR of GIRK1/2 activators: Synthesis and Biological Characterization of In Vitro Tool Compounds

ChemMedChem, Accepted Article.
The work presented herein outlines the ongoing structure‐activity relationship (SAR) studies centered around a potent, efficacious, and selective activators of the GIRK1/2 channel. Optimization studies centered around the pyrazole privileged scaffold, the N‐1‐position of the pyrazole and the right‐hand ether.
Sumaiya Nahid, Fahad Imtiaz Rahman, Yu Du, Brittany Spitznagel, Sandeep K Singh, Yashpal Chhonker, Daryl J Murry, David Weaver, Corey R Hopkins   +8 more
wiley   +1 more source

Comments on the Eslicarbazepine Acetate Section of the Article ‘Therapeutic Drug Monitoring of the Newer Anti-Epilepsy Medications’

Pharmaceuticals, 2010
The recent review of Matthew D. Krasowski on ‘Therapeutic Drug Monitoring of the Newer Anti-Epilepsy Medications’ is a useful foundation of comparative interpretations on our current knowledge about therapeutic drug monitoring.
Patricio Soares-da-Silva, Ahmet H. Öztiryaki   +1 more
doaj   +1 more source

Semikarbazon – svestrani farmakofor u dizajniranju antikonvulziva [PDF]

, 2012
During the last fifteen years semicarbazones have been extensively investigated for their anticonvulsant properties. 4-(4-Flurophenoxy) benzaldehyde semicarbazone (C0102862, V102862) has been discovered as a lead molecule and is being developed as a ...
SURENDRA NATH PANDEYA
core   +2 more sources

Novel quinazolinones active against multidrug‐resistant Mycobacterium tuberculosis: synthesis, antimicrobial evaluation and in silico exploration of PonA1 as a potential target

ChemMedChem, Accepted Article.
Quinazolinone derivatives have emerged as promising scaffolds in antimicrobial drug discovery. This work focuses on the design, synthesis, and evaluation of novel quinazolinone‐based compounds and predicts their potential to interact with mycobacterial penicillin‐binding proteins (PBPs).
MAREK KERDA, Daria Nawrot, Petr Slechta, Mirek Domanský, Asal Askari, Hanieh Kamangar, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Ingrid Hlbočanová, Miloslav Macháček, Matteo Mori, Fiorella Meneghetti, Martin Doležal, Jan Zitko, Ghada Bouz   +15 more
wiley   +1 more source

Unruptured brain arteriovenous malformations causing seizures localize to one common brain network

Journal of Neuroscience Research, Volume 101, Issue 2, Page 245-255, February 2023., 2023
Seizures are a frequent symptom of unruptured brain arteriovenous malformations (bAVMs). Using VLSM and LNM analyses, we indicated that unruptured bAVMs causing seizures, while anatomically heterogeneous, were located within a common network, which could be a plausible neuroimaging biomarker for the prediction of possible seizures.
Shao‐Zhi Zhao, Yu‐Xin Zhao, Xiao‐Hua Liao, Ran Huo, Hao Li, Yu‐Ming Jiao, Jian‐Cong Weng, Jie Wang, Bing Liu, Yong Cao   +9 more
wiley   +1 more source

Epilepsy and pregnancy

Неврология, нейропсихиатрия, психосоматика
There are currently about 15 million women of childbearing age worldwide who suffer from epilepsy. Overall, 0.3–0.4% of newborns are born to mothers with epilepsy, and almost half of these women experience recurrent seizures. The article discusses issues
P. N. Vlasov, A. M. Azhigova, E. B. Efimkova, V. A. Petrukhin   +3 more
doaj   +1 more source

An overview of analgesics - anticonvulsants, antidepressants, and other medications (Part 3)

South African Family Practice, 2019
Pain is classified by various descriptions. Chronic pain has been described as being neuropathic (due to nervous system lesions), nociceptive (due to tissue damage), or mixed (a combination of neuropathic and nociceptive).
R. van Rensburg, H. Reuter
doaj   +1 more source