Results 251 to 260 of about 111,563 (381)

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

British Journal of Pharmacology, EarlyView.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert, Chantal Fitterer, Sylvain Hugel, Mila Jesic, Yannick Goumon, Virgine Andry, Severine Schneider, Francois Daubeuf, Abdelfattah Faouzi, Stephane Doridot, Susruta Majumdar, Frederic Bihel, Martine Schmitt, Dominique Massotte   +13 more
wiley   +1 more source

Clinical prescription of lithium, anticonvulsants antipsychotics, and antidepressants for major mood disorders. [PDF]

Int J Bipolar Disord
Hernandorena C, Dines M, Miola A, Nuñez NA, Tondo L, Baldessarini RJ, Vázquez GH.   +6 more
europepmc   +1 more source

Anticonvulsant activity of methanolic extract from Kalanchoe pinnata (Lam.) stems and roots in mice: A comparison to diazepam

, 2016
Armando Mora-Pérez, María del Rosario Hernández‐Medel   +1 more
openalex   +2 more sources

Feedback control of excitability and high K+ induced epileptiform bursts in male rat hippocampal slices with a photocaged adenosine A1 receptor agonist

British Journal of Pharmacology, EarlyView.
Background and Purpose Adenosine is a potent regulator of neurotransmission and neuronal excitability, through activation of Gi coupled adenosine A1 receptors (A1Rs). Adenosine has gained interest as an anticonvulsant because of its endogenous involvement in ending seizure activity, but peripheral side effects require local application.
Erine Craey, Marijke Vergaelen, Serge Van Calenbergh, Jeroen Spanoghe, Evelien Carrette, Kristl Vonck, Paul Boon, Wytse J. Wadman, Robrecht Raedt   +8 more
wiley   +1 more source

Diagnosis and management of presumptive cyclic vomiting syndrome in a dog: first report in veterinary medicine. [PDF]

BMC Vet Res
Joo JB, Kim K, Ro WB, Lee CM.
europepmc   +1 more source

Anticonvulsants in neuropathic pain: rationale and clinical evidence

European Journal of Pain, 2002
T. Jensen
semanticscholar   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Associations between medication use and multiple domains of cognitive function in people with multiple Sclerosis. [PDF]

Mult Scler Relat Disord
Kim J, Ginell KM, Marecle S, Wernimont C, Braley TJ, Ehde DM, Alschuler KN, Fritz NE, Kratz AL.   +8 more
europepmc   +1 more source

The Anticonvulsant Effects of Different Cannabis Extracts in a Zebrafish Model of Epilepsy [PDF]

Karen Jackson, Maytal Shabat-Simon, Jean‐Claude Baron, Rafi Steckler, Soliman Khatib, Snait Tamir, Paula Adriana Pitashny   +6 more
openalex   +1 more source

Expansion of the Phenotypic and Genotypic Spectrum for PRKAR1B‐Related Marbach–Schaaf Neurodevelopmental Syndrome: A Case Series

Clinical Genetics, EarlyView.
Comprehensive clinical description of 12 subjects with pathogenic PRKAR1B variants, including two heterozygous deletions supporting haploinsufficiency as a possible mechanism of disease, providing valuable insight into the pathophysiology of MASNS and setting a framework upon which to design future mechanistic studies of PKA signaling in brain ...
Sebastian Burkart, Tarik Guzeloglu, Ana R. Soares, Irene Valenzuela, Eduardo F. Tizzano, David Gómez‐Andres, Laurent Pasquier, Marine Legendre, Camille Berges, Julien Thevenon, Marjolaine Gauthier, Caleb Heid, Elly Ranum, Joseph Shen, Michelle Frees, Michael W. Schmidtke, Caro Pilar, Christian P. Schaaf   +17 more
wiley   +1 more source