Results 11 to 20 of about 76,941 (213)

Características clínicas e inmunológicas de pacientes con déficit de anticuerpos específicos contra antígenos polisacáridos en un hospital pediátrico de Colombia [PDF]

Biomédica: revista del Instituto Nacional de Salud
Introducción. La deficiencia de anticuerpos específicos es un tipo de error innato de la inmunidad humoral, caracterizado por niveles normales de isotipos de inmunoglobulinas, infecciones recurrentes y reducción en la reacción vacunal ante antígenos ...
Lina M. Castaño-Jaramillo, Alejandra Munevar, Andrea Carolina Marín, Milena Villamil, Sonia Restrepo, Natalia Vélez   +5 more
doaj   +2 more sources

Cytokine transcriptome profiling in acute experimental canine atopic dermatitis skin lesions after IL‐31 inhibition with lokivetmab

Veterinary Dermatology, Volume 34, Issue 4, Page 327-338, August 2023., 2023
Background – The caninised monoclonal antibody lokivetmab (LKV), directed at interleukin (IL)‐31, is very effective at controlling pruritus in most dogs with atopic dermatitis (AD). However, evidence exists that IL‐31 is not required for the induction of acute allergic skin inflammation, which might explain why this treatment is less efficacious in ...
Chie Tamamoto‐Mochizuki, Natalie Crawford, Jordan M. Eder, Andrea J. Gonzales, Thierry Olivry   +4 more
wiley   +1 more source

A masked, randomised clinical trial evaluating the efficacy and safety of lokivetmab compared to saline control in client‐owned dogs with allergic dermatitis

Veterinary Dermatology, Volume 32, Issue 5, Page 477-e131, October 2021., 2021
Background – Interleukin (IL)‐31 is an important mediator in canine atopic dermatitis (cAD) and also may be dysregulated in other allergic diseases. Hypothesis/Objectives – To demonstrate the efficacy and safety of lokivetmab (canine anti‐IL‐31 monoclonal antibody) for treatment of pruritus associated with allergic dermatitis in dogs.
Leen Van Brussel, Hilde Moyaert, Monica Escalada, Sean P. Mahabir, Michael R. Stegemann   +4 more
wiley   +1 more source

Immunopathogenesis of the feline atopic syndrome

Veterinary Dermatology, Volume 32, Issue 1, Page 13-e4, February 2021., 2021
Résumé Contexte Les maladies félines supposées d’origine allergique avec des phénotypes cliniques semblables, peuvent avoir de nombreuses pathogénies différentes sous jacentes. Le phénotype clinque, l’étiologie précise et l’immunopathogénie sous jacente doivent tous être considérés si des avancées veulent être faites dans ces domaines négligés de la ...
Richard Halliwell, Frane Banovic, Ralf S. Mueller, Thierry Olivry   +3 more
wiley   +1 more source

Serum canine thymus and activation‐regulated chemokine (TARC/CCL17) concentrations correlate with disease severity and therapeutic responses in dogs with atopic dermatitis

Veterinary Dermatology, Volume 31, Issue 6, Page 446-455, December 2020., 2020
Background – Thymus and activation‐regulated chemokine (TARC/CCL17) has been implicated in the pathogenesis of canine atopic dermatitis (cAD). Serum TARC concentrations are a reliable biomarker for human atopic dermatitis; however, their potential as a biomarker for cAD has not been investigated.
Ryota Asahina, Kazunori Ueda, Yuri Oshima, Toshitaka Kanei, Masahiro Kato, Masutaka Furue, Toshihiro Tsukui, Masahiko Nagata, Sadatoshi Maeda   +8 more
wiley   +1 more source

Detection and Inhibition of IgE for cross‐reactive carbohydrate determinants evident in an enzyme‐linked immunosorbent assay for detection of allergen‐specific IgE in the sera of dogs and cats

Veterinary Dermatology, Volume 31, Issue 6, Page 439-e116, December 2020., 2020
Background It has been demonstrated recently that immunoglobulin (Ig)E specific for cross‐reactive carbohydrate determinants (CCD) is present in the serum of allergen‐sensitized dogs and cats, and that these CCD‐specific antibodies might confound serological testing. Hypothesis/Objective The objective was to document the prevalence of CCD detectable in
Kenneth W. Lee, Brennan H. McKinney, Karen D. Blankenship, Daniel O. Morris   +3 more
wiley   +1 more source

Discrepancies in the bilateral intradermal test and serum tests in atopic horses

Veterinary Dermatology, Volume 31, Issue 5, Page 390-e104, October 2020., 2020
Background – In equine atopic patients intradermal testing (IDT) and immunoglobulin (Ig)E serology are used frequently. There is little evidence regarding the reproducibility of the IDT and IgE serology in horses. Objectives – To compare the results of a simultaneously performed IDT on the left and right side of the neck in atopic horses, and to ...
Catharina M. M. van Damme, Jan van den Broek, Marianne M. Sloet van Oldruitenborgh‐Oosterbaan   +2 more
wiley   +1 more source

The African swine fever virus isolate Belgium 2018/1 shows high virulence in European wild boar

Transboundary and Emerging Diseases, Volume 67, Issue 4, Page 1654-1659, July 2020., 2020
Abstract African swine fever (ASF) is one of the most important and complex viral diseases in domestic pigs and wild boar. Over the last decade, the disease has spread to several European and Asian countries and is now one of the major threats to profitable pig production worldwide. One of the more recently affected western countries is Belgium.
Jutta Pikalo, Marie‐Eve Schoder, Julia Sehl, Angele Breithaupt, Maryléne Tignon, Ann Brigitte Cay, Anna Maria Gager, Melina Fischer, Martin Beer, Sandra Blome   +9 more
wiley   +1 more source

Predictive immunohistochemical features for tumour response to chemoradiotherapy in rectal cancer

BJS Open, Volume 4, Issue 2, Page 301-309, April 2020., 2020
The combination of reduced expression of cluster of differentiation (CD) 133 and cyclo‐oxygenase (COX) 2 and increased density of CD8+ tumour‐infiltrating lymphocytes is a significant predictor of tumour response to preoperative chemoradiotherapy (CRT).
E. Shinto, J. Omata, A. Sikina, A. Sekizawa, Y. Kajiwara, K. Hayashi, Y. Hashiguchi, K. Hase, H. Ueno   +8 more
wiley   +1 more source

Endothelium capture‐based liver segment imaging using vascular endothelial growth factor receptor 2 in preclinical ex vivo models

BJS Open, Volume 4, Issue 2, Page 332-341, April 2020., 2020
Imaging of liver segments provides substantial information for surgeons when performing liver resection. The anti‐vascular endothelial growth factor receptor (VEGFR) 2 antibody ramucirumab conjugated with near‐infrared dye could visualize selected liver segments using an endothelial capture‐based approach in an isolated perfusion liver model.
D. Kyuno, B. Qian, W. Groß, M. Schäfer, E. Ryschich   +4 more
wiley   +1 more source