Antidepressants in adolescence
Australian Prescriber, 2022 In adolescence, antidepressants are second-line treatment options after psychological therapy for anxiety and obsessive compulsive disorder. They may be first- or second-line options for severe cases of major depressive disorder. The response to antidepressant treatment is generally good for anxiety and obsessive compulsive disorder, but is less ...
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Time Course of Changes in Peripheral Blood Gene Expression During Medication Treatment for Major Depressive Disorder. [PDF]
, 2019 Changes in gene expression (GE) during antidepressant treatment may increase understanding of the action of antidepressant medications and serve as biomarkers of efficacy.
Congdon, Eliza +6 more
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Experimental Pharmacological Research Regarding the Potential Antidepressant Activity Induced by Some Newly Synthesised Dibenzo[a,d]cycloheptene Compounds [PDF]
, 2015 Background. Depression is a relatively frequent encountered mental disorder in the general population, affecting both the quality of the individual life and its ability to perform the social tasks; it is generally accepted that new studies related to ...
Junghină, Adrian +3 more
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Citalopram plus low-dose pipamperone versus citalopram plus placebo in patients with major depressive disorder: an 8-week, double-blind, randomized study on magnitude and timing of clinical response [PDF]
, 2011 Background: Selective serotonin reuptake inhibitors take several weeks to achieve their full antidepressant effects. Post-synaptic 5-HT<sub>2A</sub> receptor activation is thought to be involved in this delayed therapeutic effect ...
A. F. Schatzberg +14 more
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Antidepressant or antidepressant plus placebo effect? [PDF]
World Psychiatry, 2015 Since the first observations of the therapeutic effect of imipramine, an extensive armamentarium of effective antidepressant medications has been developed, but the level of efficacy achieved appears to be considerably less today than might have been predicted from the discoveries of more than 40 years ago.
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Medwave, 2012 Introduction: Attention deficit hyperactivity disorder (ADHD) is generally treated with pharmacologic and non-pharmacologic interventions. Pharmacological treatment is necessary for most patients.
José Calleja, José Uribarri
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Industry withdrawal from psychiatric medication development
Brazilian Journal of Psychiatry, 2014 Between 1950 and 1969, on a serendipitous basis, psychiatric drug development flourished. However, there has been a steep decline in the development of new medication classes.
Donald F. Klein, Ira D. Glick
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Clinical effectiveness and cost-effectiveness of cognitive behavioural therapy as an adjunct to pharmacotherapy for treatment-resistant depression in primary care: the CoBalT randomised controlled trial [PDF]
, 2014 Background: Only one-third of patients with depression respond fully to treatment with antidepressant medication. However, there is little robust evidence to guide the management of those whose symptoms are 'treatment resistant'.<p></p> ...
Abel, Anna +22 more
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Medicaid spending burden among beneficiaries with treatment-resistant depression. [PDF]
, 2019 AIM: To evaluate Medicaid spending and healthcare resource utilization (HRU) in treatment-resistant depression (TRD). MATERIALS & METHODS: TRD beneficiaries were identified from Medicaid claims databases (January 2010-March 2017) and matched 1:1 with ...
Greenberg, Paul E. +7 more
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Controlled Assessment of Antidepressant Drugs, Including Tofrānil [PDF]
, 1959 John W. Lovett Doust +4 more
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