Results 81 to 90 of about 122,258 (265)

Enhancing antidepressant safety surveillance: comparative analysis of adverse drug reaction signals in spontaneous reporting and healthcare claims databases

Frontiers in Pharmacology
Background/Objective: Spontaneous reporting systems (SRS) such as the Korea Adverse Event Reporting System (KAERS) are limited in their ability to detect adverse drug reaction (ADR) signals due to their limited data on drug use.
Taehyung Kim, Taehyung Kim, Xinying Jiang, Youran Noh, Youran Noh, Maryanne Kim, Maryanne Kim, Song Hee Hong, Song Hee Hong   +8 more
doaj   +1 more source

Comparable Infection Risk of Ocrelizumab and Rituximab in Multiple Sclerosis in a Nationwide Swedish Cohort Study

Annals of Neurology, EarlyView.
In multiple sclerosis (MS), anti‐CD20 therapies have been associated with increased infection risk, but whether this risk differs between rituximab and ocrelizumab is not known. Using a nationwide cohort, we studied infection risk and relapse outcomes among 16,872 treatment episodes with rituximab, ocrelizumab, or other disease‐modifying therapies ...
Thomas Frisell, Sebastian Hedberg, Fredrik Piehl   +2 more
wiley   +1 more source

Design, synthesis, and biological evaluation of piperazine derivatives involved in the 5-HT1AR/BDNF/PKA pathway

Journal of Enzyme Inhibition and Medicinal Chemistry
In this study, four series of piperazine derivatives were designed, synthesised and subjected to biological test, and compound 6a with potential antidepressant activity was obtained. An affinity assay of compound 6a with 5-hydroxytryptamine (serotonin, 5-
Hao Zhou, Mengjiao Li, Hui Liu, Zheng Liu, Xuekun Wang, Shiben Wang   +5 more
doaj   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Association Between Depression, Anxiety, and Antidepressant Use With T-Wave Amplitude and QT-Interval

Frontiers in Neuroscience, 2018
Objectives: Cardiac repolarization may be affected by psychiatric disorders and/or antidepressant use, but evidence for this is inconclusive. This study examined the relationship between depressive and anxiety disorder and use of antidepressants with T ...
Mandy X. Hu, Femke Lamers, Brenda W. J. H. Penninx, Eco J. C. de Geus   +3 more
doaj   +1 more source

Loss of Reduction and Clavicle Fractures Commonly Occur in Patients Undergoing Acromioclavicular Joint Reconstruction and Female Sex Is Associated With Higher Fracture Risk

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To use a large, multi‐institutional database to characterize the outcomes and complication profile after primary acromioclavicular (AC) joint reconstruction and to evaluate potential sex‐related differences in outcomes and complications. Methods The TriNetX national database was queried for patients undergoing AC joint reconstruction between ...
Scott Fong, Arthur Saroyan, Rajiv S. Vasudevan, Michael S. Lee, Louise A. Atadja, Peter F. Monahan, Jay Moran, Kevin Girardi, Jacob D. Kodra, Jonathan Salandra, Andrew E. Jimenez   +10 more
wiley   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials: Antidepressants for Restricted and Repetitive Behaviors in Autism Spectrum Disorder

Neuropsychiatric Disease and Treatment
Prapinpatch Maneeton,1 Benchalak Maneeton,2 Yanisa Winichaikul,3 Suttipong Kawilapat,2 Nongluck Kienngam,4 Narong Maneeton2 1Chiang Mai University Demonstration School, Faculty of Education, Chiang Mai University, Chiang Mai, Thailand; 2Department of ...
Maneeton P, Maneeton B, Winichaikul Y, Kawilapat S, Kienngam N, Maneeton N   +5 more
doaj  

Expression of monoamine transporters, nitric oxide synthase 3 and neurotrophin genes in antidepressant-stimulated astrocytes

Frontiers in Psychiatry, 2012
Background: There is increasing evidence that glial cells play a role in the pathomechanisms of mood disorders and the mode of action of antidepressant drugs.
Sarah eKittel-Schneider, Gunter eKenis, Julia eSchek, Daniel evan den Hove, Daniel evan den Hove, Jos ePrickaerts, Klaus Peter eLesch, Klaus Peter eLesch, Harry eSteinbusch, Andreas eReif   +9 more
doaj   +1 more source

Visual Responsivity in Autism: Measuring Visual Responses in Autistic and Non‐Autistic Adults Using Psychophysics, fMRI, and EEG

Autism Research, EarlyView.
ABSTRACT Autistic individuals frequently report heightened sensitivity to visual stimuli, often described as discomfort in environments with bright or flickering lights. These experiences are hypothesized to reflect underlying differences in sensory gain or neural hyperexcitability; however, findings across studies have yielded mixed results, likely ...
Daniela L. Seczon, Kristin M. Woodard, Tamar Kolodny, Hannah M. Rea, Mark Pettet, Sara Jane Webb, Scott O. Murray   +6 more
wiley   +1 more source