Results 81 to 90 of about 175,215 (214)

Soluble Epoxide Hydrolase Inhibitor: A Novel Potential Therapeutic or Prophylactic Drug for Psychiatric Disorders

Frontiers in Pharmacology, 2019
Psychiatric disorders, including depression and schizophrenia, affect millions of individuals worldwide. However, the precise neurobiology of psychiatric disorders remains unclear. Accumulating evidence suggests that various inflammatory processes play a
Qian Ren, Qian Ren
doaj   +1 more source

Functional connectivity of brain structures correlates with treatment outcome in Major Depressive Disorder

Frontiers in Psychiatry, 2011
Identifying biosignatures to assess the probability of response to an antidepressant for patients with Major Depressive Disorder (MDD) is critically needed. Functional connectivity MRI (fcMRI) offers the promise to provide such a measure.
F. Andrew eKozel, Uma eRao, Hanzhang eLu, Paul A. Nakonezny, Paul A. Nakonezny, Bruce eGrannemann, Tamara eMcGregor, Paul E. Croarkin, Kimberly S. Mapes, Carol A Tamminga, Madhukar H. Trivedi   +10 more
doaj   +1 more source

Enhancing antidepressant safety surveillance: comparative analysis of adverse drug reaction signals in spontaneous reporting and healthcare claims databases

Frontiers in Pharmacology
Background/Objective: Spontaneous reporting systems (SRS) such as the Korea Adverse Event Reporting System (KAERS) are limited in their ability to detect adverse drug reaction (ADR) signals due to their limited data on drug use.
Taehyung Kim, Taehyung Kim, Xinying Jiang, Youran Noh, Youran Noh, Maryanne Kim, Maryanne Kim, Song Hee Hong, Song Hee Hong   +8 more
doaj   +1 more source

Design, synthesis, and biological evaluation of piperazine derivatives involved in the 5-HT1AR/BDNF/PKA pathway

Journal of Enzyme Inhibition and Medicinal Chemistry
In this study, four series of piperazine derivatives were designed, synthesised and subjected to biological test, and compound 6a with potential antidepressant activity was obtained. An affinity assay of compound 6a with 5-hydroxytryptamine (serotonin, 5-
Hao Zhou, Mengjiao Li, Hui Liu, Zheng Liu, Xuekun Wang, Shiben Wang   +5 more
doaj   +1 more source

Avaliação da associação entre o efeito neuroprotetor e antidepressivo da atorvastatina em camundongos: [dissertação] [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.A excitotoxicidade glutamatérgica têm sido correlacionada com a patofisiologia da depressão e a modulação deste ...
Ludka, Fabiana Kalyne
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Association Between Depression, Anxiety, and Antidepressant Use With T-Wave Amplitude and QT-Interval

Frontiers in Neuroscience, 2018
Objectives: Cardiac repolarization may be affected by psychiatric disorders and/or antidepressant use, but evidence for this is inconclusive. This study examined the relationship between depressive and anxiety disorder and use of antidepressants with T ...
Mandy X. Hu, Femke Lamers, Brenda W. J. H. Penninx, Eco J. C. de Geus   +3 more
doaj   +1 more source

Investigação do efeito do ácido ascórbico em modelos animais preditivos de ação antidepressiva [PDF]

, 2009
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.Ascorbic acid, commonly known as vitamin C, is a water-soluble antioxidant vitamin that participates in a wide ...
Binfaré, Ricardo Wabner
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Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials: Antidepressants for Restricted and Repetitive Behaviors in Autism Spectrum Disorder

Neuropsychiatric Disease and Treatment
Prapinpatch Maneeton,1 Benchalak Maneeton,2 Yanisa Winichaikul,3 Suttipong Kawilapat,2 Nongluck Kienngam,4 Narong Maneeton2 1Chiang Mai University Demonstration School, Faculty of Education, Chiang Mai University, Chiang Mai, Thailand; 2Department of ...
Maneeton P, Maneeton B, Winichaikul Y, Kawilapat S, Kienngam N, Maneeton N   +5 more
doaj  

Expression of monoamine transporters, nitric oxide synthase 3 and neurotrophin genes in antidepressant-stimulated astrocytes

Frontiers in Psychiatry, 2012
Background: There is increasing evidence that glial cells play a role in the pathomechanisms of mood disorders and the mode of action of antidepressant drugs.
Sarah eKittel-Schneider, Gunter eKenis, Julia eSchek, Daniel evan den Hove, Daniel evan den Hove, Jos ePrickaerts, Klaus Peter eLesch, Klaus Peter eLesch, Harry eSteinbusch, Andreas eReif   +9 more
doaj   +1 more source

Estudos pré-clínicos para caracterização do ácido ascórbico como uma nova alternativa para o tratamento da depressão [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-graduação em Bioquímica, Florianópolis, 2013A bubectomia olfatória (BO) é um modelo animal de depressão bem estabelecido na literatura capaz de ...
Moretti, Morgana
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