Results 91 to 100 of about 121,953 (266)

Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials: Antidepressants for Restricted and Repetitive Behaviors in Autism Spectrum Disorder

Neuropsychiatric Disease and Treatment
Prapinpatch Maneeton,1 Benchalak Maneeton,2 Yanisa Winichaikul,3 Suttipong Kawilapat,2 Nongluck Kienngam,4 Narong Maneeton2 1Chiang Mai University Demonstration School, Faculty of Education, Chiang Mai University, Chiang Mai, Thailand; 2Department of ...
Maneeton P, Maneeton B, Winichaikul Y, Kawilapat S, Kienngam N, Maneeton N   +5 more
doaj  

Expression of monoamine transporters, nitric oxide synthase 3 and neurotrophin genes in antidepressant-stimulated astrocytes

Frontiers in Psychiatry, 2012
Background: There is increasing evidence that glial cells play a role in the pathomechanisms of mood disorders and the mode of action of antidepressant drugs.
Sarah eKittel-Schneider, Gunter eKenis, Julia eSchek, Daniel evan den Hove, Daniel evan den Hove, Jos ePrickaerts, Klaus Peter eLesch, Klaus Peter eLesch, Harry eSteinbusch, Andreas eReif   +9 more
doaj   +1 more source

Intravenous Reelin rescues despair-like behavior, Reelin cells in the dentate sub-granular zone, and spleen atrophy in the cyclic corticosterone model of recurring depressive episodes

Frontiers in Pharmacology
Novel antidepressants are predominantly evaluated preclinically in rodent models of chronic stress in which animals experience a single prolonged exposure to chronic stress prior to treatment. Rodent models of a single episode of chronic stress translate
B. S. Reive, J. Johnston, C. L. Sánchez-Lafuente, Kaylene Scheil, K. Kurz, L. E. Kalynchuk, H. J. Caruncho   +6 more
doaj   +1 more source

Different pH-sensitivity patterns of 30 sodium channel inhibitors suggest chemically different pools along the access pathway.

Frontiers in Pharmacology, 2015
The major drug binding site of sodium channels is inaccessible from the extracellular side, drug molecules can only access it either from the membrane phase, or from the intracellular aqueous phase.
Alexandra eLazar, Nora eLenkey, Krisztina ePesti, Krisztina ePesti, Laszlo eFodor, Arpad eMike   +5 more
doaj   +1 more source

Zuranolone: A case study in (regulatory) rush to judgement?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove, Milutin Kostic, Barbara Mintzes, Gianna D'Ambrozio, Allen Shaughnessy   +4 more
wiley   +1 more source

Effects of pharmacogenomics-guided treatment on medication adherence and the antidepressant switching rate in major depressive disorder

Frontiers in Pharmacology
BackgroundIn the treatment of depression, medication plays a crucial role. However, insufficient patient adherence to medication often results in unsatisfactory treatment outcomes, increasing both the recurrence and rehospitalization rates of depression,
Chaoli Chen, Yang Lun, Jing Yu, Jing Yu, Xiaochuan Zhao, Shi Su, Shi Su, Mengqiang Zhao, Yuhang Yan, Jiaqi Wang, Ran Fu, Feiyue An, Liguang Duan, Leting Yan, Ruxing Li, Jinxiao Li, Ziyu Liu, Xiaoying Geng, Jincheng Wang, Yuanyuan Zhao, Yuanyuan Zhao, Chunhua Zhou, Chunhua Zhou   +22 more
doaj   +1 more source

Quality indicators for safe and effective medication use in long‐term care facilities: A modified Delphi study

British Journal of Clinical Pharmacology, EarlyView.
Aim This modified Delphi study aimed to achieve expert agreement on quality indicators (QIs) suitable for application at the population level, to evaluate quality use of medications and pharmacist services in long‐term care facilities (LTCFs). Methods We conducted a two‐round modified online Delphi study with a multidisciplinary panel of Australian ...
Daria S. Gutteridge, Sara Javanparast, Annabel H. Calder, Gillian E. Caughey, Andrew C. Stafford, Gregory M. Peterson, Maria C. Inacio, Peter D. Hibbert, Elizabeth Manias, Jodie B. Hillen, Janet K. Sluggett   +10 more
wiley   +1 more source

Psychotropic medication use among community dwellers with and without Parkinson's disease – A nationwide cohort study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims We studied the prevalence of psychotropic use and psychotropic polypharmacy in persons with Parkinson's disease (PD) during a 10‐year follow‐up, because longitudinal studies on this topic are scarce although non‐motor symptoms of PD are often treated with psychotropics.
Noora Nieminen, Anna‐Maija Tolppanen, Valtteri Kaasinen, Marjaana Koponen, Sirpa Hartikainen   +4 more
wiley   +1 more source

Active surveillance of drug safety in healthcare data: Sequential monitoring of bacterial and serious urinary tract infection risk in sodium‐glucose cotransporter 2 inhibitor users

British Journal of Clinical Pharmacology, EarlyView.
Abstract Introduction Active surveillance of adverse events using healthcare data is emerging as complementary to the monitoring of spontaneous reports and stand‐alone pharmacoepidemiologic studies. The risk of urinary tract infections (UTIs) was listed as a special warning for sodium‐glucose cotransporter‐2 inhibitors (SGLT2is) when marketed in Europe
Haoxin Le, Dilsad Simay Peker, Lukas Frederic Westphal, Nikolai Brun, Christine Erikstrup Hallgreen, Morten Andersen   +5 more
wiley   +1 more source

Increasing the reporting of adverse drug reaction‐related hospitalizations using an ICD‐10‐based identification workflow: A multicentre study from Switzerland

British Journal of Clinical Pharmacology, EarlyView.
Background Reporting adverse drug reactions (ADRs) is essential for drug safety. In Switzerland, healthcare professionals are legally required to report serious and unlabelled ADRs, yet under‐reporting remains widespread. We tested a novel method to increase reporting of ADR‐related hospitalizations.
Georgia Anita Weber, Sophie‐Charlotte Bartel, Michael Boch, Christoph Rosen, Michael Bodmer, Balthasar Luzius Hug, Thomas Stammschulte, Patrick E. Beeler   +7 more
wiley   +1 more source