Results 61 to 70 of about 122,258 (265)
Borylcyclopropanes: Synthetic Strategies and Applications
Angewandte Chemie, EarlyView.Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley +2 more sources
Antidepressants in adolescence
Australian Prescriber, 2022 In adolescence, antidepressants are second-line treatment options after psychological therapy for anxiety and obsessive compulsive disorder. They may be first- or second-line options for severe cases of major depressive disorder. The response to antidepressant treatment is generally good for anxiety and obsessive compulsive disorder, but is less ...
openaire +2 more sources
Advanced Science, EarlyView.Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng +10 more
wiley +1 more source
SILDENAFIL USE IN ANTIDEPRESSANT DRUGS INDUCED ERECTILE DYSFUNCTION da sildenafil kullanımı
Psychiatry and Clinical Psychopharmacology, 2021 Objective: Sildenafil is a selective inhibitor of cGMP spesific phosphodiesterase type 5 which is the main isoenzyme responsible to metabolizing cyclic GMP in the penil corpus cavernosum.
Murad Atmaca +3 more
doaj
Advanced Science, EarlyView.This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori +10 more
wiley +1 more source
The pharmacological management of depression – Update 2017
South African Family Practice, 2017 Depression affects nearly 350 million people worldwide. Local data indicates that approximately 17% of all South Africans will experience at least one episode of depression in their lifetime.
Elzbieta Osuch, Andre Marais
doaj +1 more source
The antidepressant debate [PDF]
British Journal of Psychiatry, 2002 There has been an extensive debate recently in the North American medical literature and general press concerning the efficacy of antidepressant drugs. Little of this has reached the European press.
openaire +2 more sources
VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis
Advanced Science, EarlyView.Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang +7 more
wiley +1 more source
ASSESSMENT OF SOME NEUROPHARMACOLOGICAL POTENTIAL OF METHANOL SEED EXTRACT OF HUNTERIA UMBELLATA IN EXPERIMENTAL ANIMAL MODELS [PDF]
Science Heritage JournalThis study evaluated the anxiolytic, sedative, antidepressant, and anticonvulsant effects of the methanol seed extract of Hunteria umbellata in mice using established experimental models, including the Elevated Plus Maze (EPM), Hole-board test, Rota-rod ...
James Odianosen, Oseyomon +7 more
doaj +1 more source
Melatonin Levels in 89 Individuals With Smith Magenis Syndrome
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT In patients with Smith–Magenis syndrome (SMS), an inverted circadian rhythm of melatonin (MT) contributes to the sleep disturbance. Standard treatment of sleep disturbance with MT often leads to extremely high daytime MT levels, resulting in even more sleep disorders. We therefore retrospectively evaluated the MT data of 89 SMS patients.
Wiebe Braam, Ann C. M. Smith
wiley +1 more source