Results 61 to 70 of about 121,953 (266)
Advanced Science, EarlyView.A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang +17 more
wiley +1 more source
The antidepressant debate [PDF]
British Journal of Psychiatry, 2002 There has been an extensive debate recently in the North American medical literature and general press concerning the efficacy of antidepressant drugs. Little of this has reached the European press.
openaire +2 more sources
AGING MEDICINE, EarlyView.This study investigates the regulatory effects of lactulose and polyethylene glycol (PEG) on the composition of gut microbiota in elderly constipation patients with chronic renal insufficiency by comparing the changes in microbial abundance. Both lactulose and PEG significantly modulate the gut microbiota structure, though their specific mechanisms and
Jianxia Ma +10 more
wiley +1 more source
Validation of the Patient Health Questionnaire‐2 (PHQ‐2) in Detecting Depression Among Older Adults
AGING MEDICINE, EarlyView.PHQ‐2 effectively screens for geriatric depression with the optimal cut‐off of 3 points. ABSTRACT Objectives Depression screening tools like the Patient Health Questionnaire‐2 (PHQ‐2) are commonly used to detect depression. However, its performance in elderly populations has been less extensively studied compared to its broader adult use.
Francesco Salis +6 more
wiley +1 more source
SILDENAFIL USE IN ANTIDEPRESSANT DRUGS INDUCED ERECTILE DYSFUNCTION da sildenafil kullanımı
Psychiatry and Clinical Psychopharmacology, 2021 Objective: Sildenafil is a selective inhibitor of cGMP spesific phosphodiesterase type 5 which is the main isoenzyme responsible to metabolizing cyclic GMP in the penil corpus cavernosum.
Murad Atmaca +3 more
doaj
Help‐Seeking and Substance Use Among Police Staff After the 2018 Strasbourg Christmas Market Attack
American Journal of Industrial Medicine, EarlyView.ABSTRACT Background The use of mental health services by police staff is usually low. After the 2018 attack on the Strasbourg Christmas market, police officers exposed to psychotraumatic risks were found to have a higher PTSD risk. This study aims to describe the help‐seeking and substance use by police staff after the attack.
Nathalie Nourry +7 more
wiley +1 more source
The pharmacological management of depression – Update 2017
South African Family Practice, 2017 Depression affects nearly 350 million people worldwide. Local data indicates that approximately 17% of all South Africans will experience at least one episode of depression in their lifetime.
Elzbieta Osuch, Andre Marais
doaj +1 more source
Melatonin Levels in 89 Individuals With Smith Magenis Syndrome
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT In patients with Smith–Magenis syndrome (SMS), an inverted circadian rhythm of melatonin (MT) contributes to the sleep disturbance. Standard treatment of sleep disturbance with MT often leads to extremely high daytime MT levels, resulting in even more sleep disorders. We therefore retrospectively evaluated the MT data of 89 SMS patients.
Wiebe Braam, Ann C. M. Smith
wiley +1 more source
ASSESSMENT OF SOME NEUROPHARMACOLOGICAL POTENTIAL OF METHANOL SEED EXTRACT OF HUNTERIA UMBELLATA IN EXPERIMENTAL ANIMAL MODELS [PDF]
Science Heritage JournalThis study evaluated the anxiolytic, sedative, antidepressant, and anticonvulsant effects of the methanol seed extract of Hunteria umbellata in mice using established experimental models, including the Elevated Plus Maze (EPM), Hole-board test, Rota-rod ...
James Odianosen, Oseyomon +7 more
doaj +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Tuberous sclerosis complex (TSC) is a genetic condition with multisystem neurocutaneous signs, including hamartomas, epilepsy, and neuropsychological difficulties. Although sleep disorders are increasingly recognized in TSC, they remain poorly described in adults.
Kirstin A. Risgaard +6 more
wiley +1 more source