Results 101 to 110 of about 253,402 (288)

Enhancing antidepressant safety surveillance: comparative analysis of adverse drug reaction signals in spontaneous reporting and healthcare claims databases

Frontiers in Pharmacology
Background/Objective: Spontaneous reporting systems (SRS) such as the Korea Adverse Event Reporting System (KAERS) are limited in their ability to detect adverse drug reaction (ADR) signals due to their limited data on drug use.
Taehyung Kim, Taehyung Kim, Xinying Jiang, Youran Noh, Youran Noh, Maryanne Kim, Maryanne Kim, Song Hee Hong, Song Hee Hong   +8 more
doaj   +1 more source

Functional connectivity of brain structures correlates with treatment outcome in Major Depressive Disorder

Frontiers in Psychiatry, 2011
Identifying biosignatures to assess the probability of response to an antidepressant for patients with Major Depressive Disorder (MDD) is critically needed. Functional connectivity MRI (fcMRI) offers the promise to provide such a measure.
F. Andrew eKozel, Uma eRao, Hanzhang eLu, Paul A. Nakonezny, Paul A. Nakonezny, Bruce eGrannemann, Tamara eMcGregor, Paul E. Croarkin, Kimberly S. Mapes, Carol A Tamminga, Madhukar H. Trivedi   +10 more
doaj   +1 more source

Trends in long-term prescribing of dependence forming medicines [PDF]

, 2019
Using patient-level primary care data to estimate the extent to which antidepressant medicines are prescribed to people continuously for long periods of time.
McManus, S., Nguyen, A., Sehmi, R., Smith, N.   +3 more
core  

Accelerated intermittent theta burst stimulation for suicide risk in therapy-resistant depressed patients : a randomized, sham-controlled trial [PDF]

, 2016
Objectives: We aimed to examine the effects and safety of accelerated intermittent Theta Burst Stimulation (iTBS) on suicide risk in a group of treatment-resistant unipolar depressed patients, using an extensive suicide assessment scale.
Audenaert, Kurt, Baeken, Chris, DESMYTER, STEFANIE, Duprat, Romain, Van Autreve, Sara, Van Heeringen, Cornelis   +5 more
core   +3 more sources

Autism Spectrum Disorder Among Gender‐Diverse Children and Adolescents: A National Cohort Study

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is more prevalent in transgender and gender‐diverse (TGD) individuals than in the general population, yet the specific developmental pathways within and clinical outcomes of this intersection are insufficiently understood.
Erez Topaz, Tamar Sheppes, Anat Segev‐Becker, Galit Israeli, Asaf Oren, Yael Lebenthal, Tomer Shechner, Liat Perl   +7 more
wiley   +1 more source

Design, synthesis, and biological evaluation of piperazine derivatives involved in the 5-HT1AR/BDNF/PKA pathway

Journal of Enzyme Inhibition and Medicinal Chemistry
In this study, four series of piperazine derivatives were designed, synthesised and subjected to biological test, and compound 6a with potential antidepressant activity was obtained. An affinity assay of compound 6a with 5-hydroxytryptamine (serotonin, 5-
Hao Zhou, Mengjiao Li, Hui Liu, Zheng Liu, Xuekun Wang, Shiben Wang   +5 more
doaj   +1 more source

The impact of high frequency repetitive transcranial magnetic stimulation on fine motor function in medication resistant major depression [PDF]

, 2012
<b><i>Objectives:</i></b> Although high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) over the left dorsolateral prefrontal cortex (DLPFC) has been reported to improve mood symptoms in major depressive disorder (
Baeken, Chris, De Raedt, Rudi, Sabbe, Bernard GC, Schrijvers, Didier L   +3 more
core   +1 more source

Medicaid spending burden among beneficiaries with treatment-resistant depression. [PDF]

, 2019
AIM: To evaluate Medicaid spending and healthcare resource utilization (HRU) in treatment-resistant depression (TRD). MATERIALS & METHODS: TRD beneficiaries were identified from Medicaid claims databases (January 2010-March 2017) and matched 1:1 with ...
Greenberg, Paul E., Jacques, Philippe, Lefebvre, Patrick, Lejeune, Dominique, Pilon, Dominic, Sheehan, John J., Singer, David, Szukis, Holly   +7 more
core   +1 more source

Low‐dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug–drug interaction study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Cannabidiol (CBD), the main non‐intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP‐mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol ...
Andriy A. Gorbenko, Titiaan E. Post, Pamela K. Strugala, Erica S. Klaassen, Linda E. Klumpers, Saco J. de Visser, Cristina Sempio, Jost Klawitter, Jules A. A. C. Heuberger, Geert J. Groeneveld   +9 more
wiley   +1 more source

Symptom Information in Direct-to-Consumer Antidepressant Advertising and College Students\u27 Perception of the Lifetime Risk Depression [PDF]

, 2010
While consumers’ health cognition and behavior are likely formed through multiple influences, the current study focused on the effects of exposure to specific content elements in direct-to-consumer advertising. The study revealed that consumers’ exposure
Grow, Jean M., Park, Jin Seong
core   +1 more source