Results 21 to 30 of about 254,619 (233)
A functional variant in the serotonin receptor 7 gene (HTR7), rs7905446, is associated with good response to SSRIs in bipolar and unipolar depression. [PDF]
, 2020 Predicting antidepressant response has been a clinical challenge for mood disorder. Although several genome-wide association studies have suggested a number of genetic variants to be associated with antidepressant response, the sample sizes are small and
Aitchison, Katherine J +14 more
core +2 more sources
Australian Prescriber, 2021 A biopsychosocial and lifestyle approach should be used when managing depression. Many patients seen in primary care do not require drug therapy Evidence-based treatments such as psychological therapies and antidepressant drugs are effective for depression.
Philip Boyce, Cassandra Ma
openaire +3 more sources
Frontiers in Psychiatry, 2022 Depression is a common and often recurrent illness with significant negative impact on a global scale. Current antidepressants are ineffective for up to one third of people with depression, many of whom experience persistent symptomatology.
Angharad N. de Cates +18 more
doaj +1 more source
Frontiers in Psychiatry, 2020 Schizophrenia is a severe brain disorder that is associated with neurodevelopmental insults, such as prenatal inflammation, that introduce redox-immune-inflammatory alterations and risk for psychotic symptoms later in life.
Jana Lotter +7 more
doaj +1 more source
Antidepressant Use and Depressive Symptoms in Intensive Care Unit Survivors [PDF]
, 2017 Nearly 30% of intensive care unit (ICU) survivors have depressive symptoms 2-12 months after hospital discharge. We examined the prevalence of depressive symptoms and risk factors for depressive symptoms in 204 patients at their initial evaluation in the
Boustani, Malaz +8 more
core +1 more source
FDA-Approved Amoxapine Effectively Promotes Macrophage Control of Mycobacteria by Inducing Autophagy
Microbiology Spectrum, 2022 Antibiotic resistance poses a significant hurdle in combating global public health crises, prompting the development of novel therapeutics. Strategies to enhance the intracellular killing of mycobacteria by targeting host defense mechanisms offer ...
Jia Wang +4 more
doaj +1 more source
AM-251, A Cannabinoid Antagonist, Modifies the Dynamics of Sleep–Wake Cycles in Rats
Frontiers in Pharmacology, 2019 Study Objectives: (a) To describe the microarchitecture of wakefulness and sleep following administrations of 5- and 10-mg/kg AM-251 in rats. (b) To develop a new statistical method to follow bout-to-bout dynamics.Method: Wistar rats (n = 6) had been ...
Emese Bogáthy +9 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Baicalin isolated from Scutellaria baicalensis possesses antidepressant abilities through its relation to hippocampal neurogenesis. Current research has found that baicalin can promote the proliferation of hippocampal granule cells, however, the detailed
Fan Zhao +10 more
doaj +1 more source
Neural Predictors of the Antidepressant Placebo Response
Pharmaceuticals, 2019 The antidepressant placebo response remains a barrier to the development of novel therapies for depression, despite decades of efforts to identify and methodologically address its clinical correlates.
Danielle Rette +3 more
doaj +1 more source
Frontiers in Neuroscience, 2021 Major depressive disorder (MDD) is a debilitating mental illness affecting people worldwide. Although significant progress has been made in the development of therapeutic agents to treat this condition, fewer than half of all patients respond to ...
Yuan Zhang +13 more
doaj +1 more source