Results 21 to 30 of about 153,444 (192)

Peripheral Etanercept Administration Normalizes Behavior, Hippocampal Neurogenesis, and Hippocampal Reelin and GABAA Receptor Expression in a Preclinical Model of Depression

Frontiers in Pharmacology, 2018
Depression is a serious psychiatric disorder frequently comorbid with autoimmune disorders. Previous work in our lab has demonstrated that repeated corticosterone (CORT) injections in rats reliably increase depressive-like behavior, impair hippocampal ...
Kyle J. Brymer, Erin Y. Fenton, Lisa E. Kalynchuk, Hector J. Caruncho   +3 more
doaj   +1 more source

Antidepressants

, 2015
Recent antidepressant side effects of particular interest have included bleeding risk, and effects during pregnancy and the neonatal period. While increased bleeding risk with serotonergic antidepressants has been recognised for many years, the incidence and severity of this have been uncertain—issues of particular pertinence to patients having ...
Smithson, J, Mitchell, PB
openaire   +3 more sources

Opiates as Antidepressants

Current Pharmaceutical Design, 2009
The pathophysiology of mood disorders involves several genetic and social predisposing factors, as well as a dysregulated response to a chronic stressor, i.e. chronic pain. Our present view that depression involves a dysfunction of the monoaminergic system is a result of important clinical and preclinical observations over the past 40 years.
Berrocoso, E., Sánchez-Blázquez, Pilar, Garzón, Javier, Mico, J. A.   +3 more
openaire   +4 more sources

Glycogen synthase kinase-3 in the etiology and treatment of mood disorders

Frontiers in Molecular Neuroscience, 2011
The mood disorders major depressive disorder and bipolar disorder are prevalent, are inadequately treated, and little is known about their etiologies.
Richard Scott Jope
doaj   +1 more source

Pharmacology of Antidepressants [PDF]

Psychopathology, 1987
Presently in the United States, 21 compounds have been approved by the Food and Drug Administration as antidepressants. Two additional drugs marketed outside the United States as antidepressants have been approved for obsessive-compulsive disorder.
openaire   +4 more sources

Different pH-sensitivity patterns of 30 sodium channel inhibitors suggest chemically different pools along the access pathway.

Frontiers in Pharmacology, 2015
The major drug binding site of sodium channels is inaccessible from the extracellular side, drug molecules can only access it either from the membrane phase, or from the intracellular aqueous phase.
Alexandra eLazar, Nora eLenkey, Krisztina ePesti, Krisztina ePesti, Laszlo eFodor, Arpad eMike   +5 more
doaj   +1 more source

Unveiling Pharmacological Responses and Potential Targets Insights of Identified Bioactive Constituents of Cuscuta reflexa Roxb. Leaves through In Vivo and In Silico Approaches

Pharmaceuticals, 2020
Cuscuta reflexa Roxb. is traditionally used by the indigenous communities of Bangladesh to treat different diseases, such as pain, edema, tumor, jaundice, and skin infections.
Md. Adnan, Md. Nazim Uddin Chy, A.T.M. Mostafa Kamal, Md. Riad Chowdhury, Md. Shariful Islam, Md. Amzad Hossain, Abu Montakim Tareq, Md. Imam Hossain Bhuiyan, Md Nasim Uddin, Afroza Tahamina, Md Obyedul Kalam Azad, Young Seok Lim, Dong Ha Cho   +12 more
doaj   +1 more source

Subcutaneous Ketamine in Depression: A Systematic Review

Frontiers in Psychiatry, 2021
Background: Ketamine has been shown to produce a rapid and robust antidepressant effect. Though numerous routes of administration have been studied, subcutaneous (SC) has proven to be a convenient and cost-effective route making its use particularly ...
Vitor Breseghello Cavenaghi, Leandro Paulino da Costa, Acioly Luiz Tavares Lacerda, Edson Shiguemi Hirata, Eurípedes Constantino Miguel, Renério Fraguas, Renério Fraguas   +6 more
doaj   +1 more source

Soluble Epoxide Hydrolase Inhibitor: A Novel Potential Therapeutic or Prophylactic Drug for Psychiatric Disorders

Frontiers in Pharmacology, 2019
Psychiatric disorders, including depression and schizophrenia, affect millions of individuals worldwide. However, the precise neurobiology of psychiatric disorders remains unclear. Accumulating evidence suggests that various inflammatory processes play a
Qian Ren, Qian Ren
doaj   +1 more source

Novel Insights Into the Neurobiology of the Antidepressant Response From Ketamine Research: A Mini Review

Frontiers in Behavioral Neuroscience, 2021
The serendipitous discovery of ketamine’s antidepressant effects represents one of the major landmarks in neuropsychopharmacological research of the last 50 years.
Michael Colla, Hanne Scheerer, Steffi Weidt, Erich Seifritz, Golo Kronenberg   +4 more
doaj   +1 more source