Results 21 to 30 of about 276,787 (297)

The pharmacogenetics of CYP2D6 and CYP2C19 in a case series of antidepressant responses

Frontiers in Pharmacology, 2023
Pharmacogenetics has potential for optimizing use of psychotropics. CYP2D6 and CYP2C19 are two clinically relevant pharmacogenes in the prescribing of antidepressants.
Ping Siu Kee, Simran D. S. Maggo, Simran D. S. Maggo, Martin A. Kennedy, Paul K. L. Chin, Paul K. L. Chin   +5 more
doaj   +1 more source

Facilitating Granule Cell Survival and Maturation in Dentate Gyrus With Baicalin for Antidepressant Therapeutics

Frontiers in Pharmacology, 2020
Baicalin isolated from Scutellaria baicalensis possesses antidepressant abilities through its relation to hippocampal neurogenesis. Current research has found that baicalin can promote the proliferation of hippocampal granule cells, however, the detailed
Fan Zhao, Weiwei Tao, Zhiyuan Shang, Weihua Zhang, Jie Ruan, Chenyiyu Zhang, Liping Zhou, Hunter Aiello, Hezheng Lai, Hezheng Lai, Rong Qu   +10 more
doaj   +1 more source

Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression.

ACS Chemical Neuroscience, 2020
Psilocybin shows efficacy to alleviate depression in human clinical trials for six or more months after only one or two treatments. Another hallucinogenic drug, esketamine, has recently been U.S.
M. Hibicke, Alexus N Landry, Hannah M. Kramer, Zoe K Talman, C. Nichols   +4 more
semanticscholar   +1 more source

Efficacy and Safety of Fixed-Dose Esketamine Nasal Spray Combined With a New Oral Antidepressant in Treatment-Resistant Depression: Results of a Randomized, Double-Blind, Active-Controlled Study (TRANSFORM-1)

International Journal of Neuropsychopharmacology, 2019
Background About one-third of patients with depression fail to achieve remission despite treatment with multiple antidepressants and are considered to have treatment-resistant depression.
M. Fedgchin, M. Trivedi, E. Daly, R. Melkote, R. Lane, P. Lim, D. Vitagliano, P. Blier, M. Fava, M. Liebowitz, A. Ravindran, R. Gaillard, H. Ameele, S. Preskorn, H. Manji, D. Hough, W. Drevets, Jaskaran Singh   +17 more
semanticscholar   +1 more source

Glucoraphanin Triggers Rapid Antidepressant Responses in a Rat Model of Beta Amyloid-Induced Depressive-like Behaviour

Pharmaceuticals, 2022
Glucoraphanin (GRA) is a natural compound that has shown beneficial effects in chronic diseases and in central nervous system disorders. Moreover, GRA displayed antidepressant activity in preclinical models.
Paolo Tucci, Maria Bove, Vladyslav Sikora, Stefania Dimonte, Maria Grazia Morgese, Stefania Schiavone, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Luigia Trabace   +8 more
doaj   +1 more source

Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration

PLoS Medicine, 2008
Background Meta-analyses of antidepressant medications have reported only modest benefits over placebo treatment, and when unpublished trial data are included, the benefit falls below accepted criteria for clinical significance.
I. Kirsch, B. Deacon, Tania B. Huedo-Medina, A. Scoboria, T. Moore, Blair T. Johnson   +5 more
semanticscholar   +1 more source

Intermittent fasting produces antidepressant-like effects by modulating dopamine D1 receptors in the medial prefrontal cortex

Neurobiology of Disease
Nutritional psychiatry has gained increasing attention, particularly in exploring dietary interventions for depression treatment. As a potential non-drug intervention, intermittent fasting (IF) has gradually attracted the interest of researchers, but its
Jingjing Piao, Hongyu Chen, Xinmiao Piao, Ziqian Cheng, Fangyi Zhao, Ranji Cui, Bingjin Li   +6 more
doaj   +1 more source

Antidepressants versus interpersonal psychotherapy in treating depression in HIV-positive patients.

South African Journal of Psychiatry, 2012
Aim. Despite the prevalence of HIV and AIDS in South Africa reaching pandemic proportions, very few studies have been published on co-morbid depression. This study at Chris Hani Baragwanath Hospital was conducted on a group of HIV-positive patients with ...
M Y H Moosa, F Y Jeenah
doaj   +1 more source

Neuroendocrine Assessment of Dopaminergic Function during Antidepressant Treatment in Major Depressed Patients

Brain Sciences, 2021
The effects of antidepressants on dopamine (DA) receptor sensitivity in the mesolimbic–hypothalamic system have yielded contradictory results. The postsynaptic DA receptor function was evaluated by the cortisol response to apomorphine (APO; 0.75 mg SC ...
Fabrice Duval, Marie-Claude Mokrani, Alexis Erb, Felix Gonzalez Lopera, Vlad Danila, Mihaela Tomsa   +5 more
doaj   +1 more source

NMDA Receptor Blockade at Rest Triggers Rapid Behavioural Antidepressant Responses

Nature, 2011
Clinical studies consistently demonstrate that a single sub-psychomimetic dose of ketamine, an ionotropic glutamatergic NMDAR (N-methyl-D-aspartate receptor) antagonist, produces fast-acting antidepressant responses in patients suffering from major ...
Anita E. Autry, M. Adachi, E. Nosyreva, E. Na, Maarten F. Los, Peng Cheng, E. Kavalali, L. Monteggia   +7 more
semanticscholar   +1 more source