Results 31 to 40 of about 121,953 (266)

Treatment-Resistant Depression that Recovered after Toxoplasma Gondii Treatment: A Case Report

Psychiatry and Behavioral Sciences, 2020
Toxoplasma Gondii is an obligate intracellular parasite which may infect all nucleated cells. Studies conducted in adult patients show that toxoplasmosis may be related to psychiatric diseases and there is a correlation between Toxoplasma Gondii and ...
Yekta Ozkan, Sermin Yalın Sapmaz, Semra Sen, Masum Ozturk, Hasan Kandemir   +4 more
doaj   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Agomelatin's Effect on Parkinson Disease Model on Rats

Journal of Behçet Uz Children's Hospital, 2019
INTRODUCTION: Parkinson disease is one of the most common neurodegenerative disorders. This disease still have no exact cure. Agomelatin is the synthetic analog of melatonin hormone that is synthesized in pineal gland and then released from there ...
Pınar Ayvat, Ayse Saide Sahin, Burak Cem Soner   +2 more
doaj   +1 more source

Why antidepressants are not antidepressants

Mental Health Clinician, 2012
This statement begins Dr. Ghaemi’s review of “Why antidepressants are not antidepressants: STEP-BD, STAR*D, and the return of neurotic depression“ published in Bipolar Disorders in 2008. The article addresses a segment of the controversial evidence to be presented as part of Annual Meeting recertification programming surrounding the use of ...
openaire   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

Association of inflammation cytokines with cognitive function in first-episode major depressive disorder

Frontiers in Psychiatry
ObjectiveAbnormal cognitive functioning is a core symptom of Major Depressive Disorder (MDD) and is strongly correlated with MDD prognosis. Current studies suggest that the occurrence of MDD may be related to oxidative stress-induced inflammation ...
Yan Qing Xi, Yan Qing Xi, Yan Qing Xi, Zong Qi Wang, Zong Qi Wang, Zong Qi Wang, Guo Juan Li, Guo Juan Li, Guo Juan Li, Zhuo Qun Hao, Zhuo Qun Hao, Zhuo Qun Hao, Jia Hui Nie, Jin Xiang Li, Yu Ting Tan, Xiao Dong Hu, Xiao Dong Hu, Gen Wei Wang, Sha Liu, Sha Liu, Yan Fang Wang, Yan Fang Wang, Yan Fang Wang   +22 more
doaj   +1 more source

3D-ALMOND-QSAR Models to Predict the Antidepressant Effect of Some Natural Compounds

Pharmaceutics, 2021
The current treatment of depression involves antidepressant synthetic drugs that have a variety of side effects. In searching for alternatives, natural compounds could represent a solution, as many studies reported that such compounds modulate the ...
Speranta Avram, Miruna Silvia Stan, Ana Maria Udrea, Cătălin Buiu, Anca Andreea Boboc, Maria Mernea   +5 more
doaj   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Emulating a randomized clinical trial with real-world data to evaluate the effect of antidepressant use in PTSD patients with high suicide risk

Frontiers in Psychiatry
IntroductionPost-Traumatic Stress Disorder (PTSD) entails behavioral changes with increased risk of suicide, and there is no consensus on the preferred antidepressants for treatment of those PTSD patients who are at elevated risk for suicide.MethodsWe ...
Oshin Miranda, Xiguang Qi, M. Daniel Brannock, Ryan Whitworth, Thomas Kosten, Neal David Ryan, Gretchen L. Haas, Gretchen L. Haas, Gretchen L. Haas, Levent Kirisci, LiRong Wang   +10 more
doaj   +1 more source

Design, Synthesis, and In Vivo and In Silico Evaluation of Coumarin Derivatives with Potential Antidepressant Effects

Molecules, 2021
In this study, a series of coumarin derivatives were designed and synthesized, their structures were characterized using nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS) testing methods. In the pharmacological experiment, two
Xuekun Wang, Hao Zhou, Xinyu Wang, Kang Lei, Shiben Wang   +4 more
doaj   +1 more source