Results 21 to 30 of about 174,749 (313)

Antidepressant-Like Effect of a Selenoindolizine in Mice: In Vivo and In Silico Evidence for the Involvement of the Serotonergic 5‑HT_2A/C Receptors

, 2022
The monoaminergic dysfunction plays a central role in major depressive disorder (MDD), a mental disturbance associated with constant feeling of sadness and lack of interest.
Caroline Signorini Gomes (12604157), Cleisson Schossler Garcia (12604133), Marcos Pizzatto de Azeredo (12604148), Luiz Roberto Carraro Junior (12604154), Evelyn Mianes Besckow (12604136), Carlos Natã da Silva Espíndola (12604139), Narryman Pinto Zuge (12604145), Marcia Juciele da Rocha (12604151), Gustavo D’Avila Nunes (12604142), César Augusto Brüning (12604166), Eder João Lenardão (12604160), Cristiani Folharini Bortolatto (12604163), Filipe Penteado (6694529)   +12 more
core   +1 more source

Biochemical and immunocytochemical studies of the testicular alteration caused by Amitriptyline in adult male rat [PDF]

Journal of Bioscience and Applied Research, 2018
Amitriptyline is one of the first reference tricyclic antidepressants (TCAs) with sedative and analgesic properties. This study aimed to investigate the testicular indices that influenced by amitriptyline treatment and examined it by biochemical ...
Ehab Tousson, Somia Zaki, Ezar Hafez, Amani Gad   +3 more
doaj   +1 more source

Intermittent fasting produces antidepressant-like effects by modulating dopamine D1 receptors in the medial prefrontal cortex

Neurobiology of Disease
Nutritional psychiatry has gained increasing attention, particularly in exploring dietary interventions for depression treatment. As a potential non-drug intervention, intermittent fasting (IF) has gradually attracted the interest of researchers, but its
Jingjing Piao, Hongyu Chen, Xinmiao Piao, Ziqian Cheng, Fangyi Zhao, Ranji Cui, Bingjin Li   +6 more
doaj   +1 more source

The Effect of the 5-HT4 Agonist, Prucalopride, on a Functional Magnetic Resonance Imaging Faces Task in the Healthy Human Brain

Frontiers in Psychiatry, 2022
Depression is a common and often recurrent illness with significant negative impact on a global scale. Current antidepressants are ineffective for up to one third of people with depression, many of whom experience persistent symptomatology.
Angharad N. de Cates, Angharad N. de Cates, Marieke A. G. Martens, Marieke A. G. Martens, Lucy C. Wright, Lucy C. Wright, Cassandra D. Gould van Praag, Cassandra D. Gould van Praag, Liliana P. Capitão, Liliana P. Capitão, Daisy Gibson, Daisy Gibson, Philip J. Cowen, Philip J. Cowen, Catherine J. Harmer, Catherine J. Harmer, Catherine J. Harmer, Susannah E. Murphy, Susannah E. Murphy   +18 more
doaj   +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source

Choosing an antidepressant

Australian Prescriber, 2021
A biopsychosocial and lifestyle approach should be used when managing depression. Many patients seen in primary care do not require drug therapy Evidence-based treatments such as psychological therapies and antidepressant drugs are effective for depression.
Boyce, Philip, Ma, Cassandra
openaire   +2 more sources

Multiple antidepressant potential modes of action of curcumin: A review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects [PDF]

, 2012
Curcumin is the principal curcuminoid of the popular Indian spice turmeric and has attracted increasing attention for the treatment of a range of conditions.
Hood, S.D., Adrian L Lopresti, Lopresti, A.L., Peter D Drummond, Drummond, P.D., Sean D Hood   +5 more
core  

Antidepressant-like effect of Casimiroa pubescens root extracts

, 2018
In this study, we investigated the antidepressant-like effects of the hexane (HCP), ethyl acetate (ECP) and methanol (MCP) extracts of the roots of Casimiroa pubescens Ramírez (Rutaceae) using the forced swim test (FST).
Mariano Martínez-Vázquez (4950829), Roberto De la Rosa-Sierra (4950823), Denisse Ubaldo-Suárez (4950832), Rosa Estrada Reyes (4950826)   +3 more
core   +1 more source

"In vitro" study of the mode of action of antidepressants in cell culture models : comparison of the effects of "Hypericum perforatum L." extracts and classical synthetic compounds on the [beta]-adrenergic signal pathway [PDF]

, 2005
The clinical effectiveness of the plant extract of Hypericum perforatum L. in treating mild to moderate depression is well established. The extract shows a more favourable side effect profile than other antidepressant drugs, like tricyclics and selective
Wirz, Adrian
core   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source