Results 21 to 30 of about 122,258 (265)

AM-251, A Cannabinoid Antagonist, Modifies the Dynamics of Sleep–Wake Cycles in Rats

Frontiers in Pharmacology, 2019
Study Objectives: (a) To describe the microarchitecture of wakefulness and sleep following administrations of 5- and 10-mg/kg AM-251 in rats. (b) To develop a new statistical method to follow bout-to-bout dynamics.Method: Wistar rats (n = 6) had been ...
Emese Bogáthy, Noémi Papp, Szilvia Vas, Szilvia Vas, Szilvia Vas, György Bagdy, György Bagdy, György Bagdy, György Bagdy, László Tóthfalusi   +9 more
doaj   +1 more source

Neural Predictors of the Antidepressant Placebo Response

Pharmaceuticals, 2019
The antidepressant placebo response remains a barrier to the development of novel therapies for depression, despite decades of efforts to identify and methodologically address its clinical correlates.
Danielle Rette, Erin McDonald, Dan V. Iosifescu, Katherine A. Collins   +3 more
doaj   +1 more source

Antidepressants and Age [PDF]

SSRN Electronic Journal, 2011
Antidepressants as a commodity have been remarkably little-studied by economists. \ud This study shows in new data for 27 European countries that 8% of people (and \ud 10% of those middle-aged) take antidepressants each year. The probability of \ud antidepressant use is greatest among those who are middle-aged, female, \ud unemployed, poorly educated ...
Blanchflower, David G., Oswald, Andrew J.   +1 more
openaire   +3 more sources

Association between insight and internalized stigma and other clinical factors among patients with depression: A cross-sectional study

Indian Journal of Psychiatry, 2020
Background: Insight influences treatment adherence among patients with depression. These patients also experience considerable social and self-stigma. The relationship between insight and internalized stigma has been extensively studied among patients ...
Luke Sy-Cherng Woon, Siew Im Khoo, Azlin Baharudin, Marhani Midin   +3 more
doaj   +1 more source

Biochemical and immunocytochemical studies of the testicular alteration caused by Amitriptyline in adult male rat [PDF]

Journal of Bioscience and Applied Research, 2018
Amitriptyline is one of the first reference tricyclic antidepressants (TCAs) with sedative and analgesic properties. This study aimed to investigate the testicular indices that influenced by amitriptyline treatment and examined it by biochemical ...
Ehab Tousson, Somia Zaki, Ezar Hafez, Amani Gad   +3 more
doaj   +1 more source

Intermittent fasting produces antidepressant-like effects by modulating dopamine D1 receptors in the medial prefrontal cortex

Neurobiology of Disease
Nutritional psychiatry has gained increasing attention, particularly in exploring dietary interventions for depression treatment. As a potential non-drug intervention, intermittent fasting (IF) has gradually attracted the interest of researchers, but its
Jingjing Piao, Hongyu Chen, Xinmiao Piao, Ziqian Cheng, Fangyi Zhao, Ranji Cui, Bingjin Li   +6 more
doaj   +1 more source

The Effect of the 5-HT4 Agonist, Prucalopride, on a Functional Magnetic Resonance Imaging Faces Task in the Healthy Human Brain

Frontiers in Psychiatry, 2022
Depression is a common and often recurrent illness with significant negative impact on a global scale. Current antidepressants are ineffective for up to one third of people with depression, many of whom experience persistent symptomatology.
Angharad N. de Cates, Angharad N. de Cates, Marieke A. G. Martens, Marieke A. G. Martens, Lucy C. Wright, Lucy C. Wright, Cassandra D. Gould van Praag, Cassandra D. Gould van Praag, Liliana P. Capitão, Liliana P. Capitão, Daisy Gibson, Daisy Gibson, Philip J. Cowen, Philip J. Cowen, Catherine J. Harmer, Catherine J. Harmer, Catherine J. Harmer, Susannah E. Murphy, Susannah E. Murphy   +18 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Treatment-Resistant Depression that Recovered after Toxoplasma Gondii Treatment: A Case Report

Psychiatry and Behavioral Sciences, 2020
Toxoplasma Gondii is an obligate intracellular parasite which may infect all nucleated cells. Studies conducted in adult patients show that toxoplasmosis may be related to psychiatric diseases and there is a correlation between Toxoplasma Gondii and ...
Yekta Ozkan, Sermin Yalın Sapmaz, Semra Sen, Masum Ozturk, Hasan Kandemir   +4 more
doaj   +1 more source