Results 31 to 40 of about 267,421 (217)

Peripheral Etanercept Administration Normalizes Behavior, Hippocampal Neurogenesis, and Hippocampal Reelin and GABAA Receptor Expression in a Preclinical Model of Depression

Frontiers in Pharmacology, 2018
Depression is a serious psychiatric disorder frequently comorbid with autoimmune disorders. Previous work in our lab has demonstrated that repeated corticosterone (CORT) injections in rats reliably increase depressive-like behavior, impair hippocampal ...
Kyle J. Brymer, Erin Y. Fenton, Lisa E. Kalynchuk, Hector J. Caruncho   +3 more
doaj   +1 more source

Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression.

ACS Chemical Neuroscience, 2020
Psilocybin shows efficacy to alleviate depression in human clinical trials for six or more months after only one or two treatments. Another hallucinogenic drug, esketamine, has recently been U.S.
M. Hibicke, Alexus N Landry, Hannah M. Kramer, Zoe K Talman, C. Nichols   +4 more
semanticscholar   +1 more source

Glycogen synthase kinase-3 in the etiology and treatment of mood disorders

Frontiers in Molecular Neuroscience, 2011
The mood disorders major depressive disorder and bipolar disorder are prevalent, are inadequately treated, and little is known about their etiologies.
Richard Scott Jope
doaj   +1 more source

Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration

PLoS Medicine, 2008
Background Meta-analyses of antidepressant medications have reported only modest benefits over placebo treatment, and when unpublished trial data are included, the benefit falls below accepted criteria for clinical significance.
I. Kirsch, B. Deacon, Tania B. Huedo-Medina, A. Scoboria, T. Moore, Blair T. Johnson   +5 more
semanticscholar   +1 more source

Different pH-sensitivity patterns of 30 sodium channel inhibitors suggest chemically different pools along the access pathway.

Frontiers in Pharmacology, 2015
The major drug binding site of sodium channels is inaccessible from the extracellular side, drug molecules can only access it either from the membrane phase, or from the intracellular aqueous phase.
Alexandra eLazar, Nora eLenkey, Krisztina ePesti, Krisztina ePesti, Laszlo eFodor, Arpad eMike   +5 more
doaj   +1 more source

Estimation of the marginal effect of antidepressants on body mass index under confounding and endogenous covariate-driven monitoring times [PDF]

arXiv, 2021
In studying the marginal effect of antidepressants on body mass index using electronic health records data, we face several challenges. Patients' characteristics can affect the exposure (confounding) as well as the timing of routine visits (measurement process), and those characteristics may be altered following a visit which can create dependencies ...
arxiv  

Analise Demografica e Socioeconomica do Uso e do Acesso a Medicamentos Antidepressivos no Brasil [PDF]

arXiv, 2021
Depressive disorders, in addition to causing direct negative impacts on health, are also responsible for imposing substantial costs on society. In relation to the treatment of depression, antidepressants have proven effective, and, to the World Health Organization, access to psychotropic drugs for people with mental illnesses offers a chance of ...
arxiv  

Selective publication of antidepressant trials and its influence on apparent efficacy.

New England Journal of Medicine, 2008
BACKGROUND Evidence-based medicine is valuable to the extent that the evidence base is complete and unbiased. Selective publication of clinical trials--and the outcomes within those trials--can lead to unrealistic estimates of drug effectiveness and ...
Erick H Turner, A. Matthews, E. Linardatos, Robert A Tell, R. Rosenthal   +4 more
semanticscholar   +1 more source

Efficacy and Safety of Fixed-Dose Esketamine Nasal Spray Combined With a New Oral Antidepressant in Treatment-Resistant Depression: Results of a Randomized, Double-Blind, Active-Controlled Study (TRANSFORM-1)

International Journal of Neuropsychopharmacology, 2019
Background About one-third of patients with depression fail to achieve remission despite treatment with multiple antidepressants and are considered to have treatment-resistant depression.
M. Fedgchin, M. Trivedi, E. Daly, R. Melkote, R. Lane, P. Lim, D. Vitagliano, P. Blier, M. Fava, M. Liebowitz, A. Ravindran, R. Gaillard, H. Ameele, S. Preskorn, H. Manji, D. Hough, W. Drevets, Jaskaran Singh   +17 more
semanticscholar   +1 more source

Unveiling Pharmacological Responses and Potential Targets Insights of Identified Bioactive Constituents of Cuscuta reflexa Roxb. Leaves through In Vivo and In Silico Approaches

Pharmaceuticals, 2020
Cuscuta reflexa Roxb. is traditionally used by the indigenous communities of Bangladesh to treat different diseases, such as pain, edema, tumor, jaundice, and skin infections.
Md. Adnan, Md. Nazim Uddin Chy, A.T.M. Mostafa Kamal, Md. Riad Chowdhury, Md. Shariful Islam, Md. Amzad Hossain, Abu Montakim Tareq, Md. Imam Hossain Bhuiyan, Md Nasim Uddin, Afroza Tahamina, Md Obyedul Kalam Azad, Young Seok Lim, Dong Ha Cho   +12 more
doaj   +1 more source