Results 91 to 100 of about 288,395 (355)

A preclinical mouse model mimicking the ovarian cancer‐induced estrogen deficiency‐depression axis

Animal Models and Experimental Medicine, EarlyView.
A preclinical mouse model of ovarian cancer–related depression was developed by combining intraperitoneal tumor cell injection, ovariectomy, and chronic restraint stress. The model replicates key clinical features including estrogen deficiency, depressive‐like behaviors, and tumor progression, and provides a reliable tool for studying the endocrine ...
Jiamin Liu, Yafei Yang, Chunxi Liu, Danting Wen, Tingyu Zhao, Ping Xie, Jing Xiao   +6 more
wiley   +1 more source

Fluoxetine reduces murine graft-versus-host disease by induction of T cell immunosuppression [PDF]

, 2013
Serotonin reuptake inhibitors (SRIs) are widely used drugs in the treatment of depression and anxiety disorders. Although SRIs are generally regarded as safe drugs with relatively few side effects, literature suggests that high concentrations of SRIs may
Billiau, An D, Deforce, Dieter, Denys, Damiaan, Fevery, Sabine, Gobin, Veerle, Tilleman, Kelly, Van Steendam, Katleen   +6 more
core   +3 more sources

Scalp electroacupuncture targeting trigeminal nerve activation alleviates post‐traumatic stress disorder–induced depression and neuroinflammation in mice

Animal Models and Experimental Medicine, EarlyView.
Scalp electroacupuncture (SA) through activation of the trigeminal pathway exerts anti‐inflammatory, antidepressant, and anxiolytic effects in an animal model of post‐traumatic stress disorder induced by single prolonged stress. This suggests that SA is involved in neuroinflammation and changes in brain‐derived neurotrophic factor protein through the ...
Bombi Lee, Yoongeum Kim, Hyungjun Kim, Dae‐Hyun Hahm   +3 more
wiley   +1 more source

Risk of manic switch with antidepressants use in patients with bipolar disorder in a Nigerian neuropsychiatric hospital

South African Journal of Psychiatry, 2018
Background: Depressive disorders are common among those with bipolar affective disorder (BAD) and may necessitate the use of antidepressants. This has been suggested to precipitate manic episodes in some patients.
Ayodele L. Fela-Thomas, Osasu S. Olotu, Oluyomi Esan   +2 more
doaj   +1 more source

Attitudes toward depression among Japanese non-psychiatric medical doctors: A cross-sectional study [PDF]

, 2012
Background: Under-recognition of depression is common in many countries. Education of medical staff, focusing on their attitudes towards depression, may be necessary to change their behavior and enhance recognition of depression.
Haddad, M., Inagaki, M., Ishikura, F., Kodaka, M., Mann, A., Ohtsuki, T., Sakai, R., Watanabe, Y., Yamada, M.   +8 more
core   +1 more source

Distinct Prescription Patterns Emerge Years Before ALS Diagnosis: A Nationwide Registry‐Based Study

Annals of Neurology, EarlyView.
Objective The prodromal phase of amyotrophic lateral sclerosis (ALS) is poorly defined. We aimed to characterize prescription drug use patterns in the pre‐diagnostic period by analyzing nationwide prescription data to identify the earliest divergence between individuals who developed ALS and matched healthy controls.
Magne Haugland Solheim, Trond Riise, Marianna Cortese, Ola Nakken, Ole‐Bjørn Tysnes, Jannicke Igland, Kjetil Bjornevik   +6 more
wiley   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

D-cycloserine augmentation of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders: a systematic review and meta-analysis of individual participant data [PDF]

, 2017
Importance: Whether and under which conditions D-cycloserine (DCS) augments the effects of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders is unclear.
Altemus, Margaret, Anderson, Page, Andersson, Erik, Cukor, Judith, Davis, Michael, DCS Anxiety Consortium, de Kleine, Rianne A., Difede, JoAnn, Dunlop, Boadie W., Farrell, Lara J., Fernández de la Cruz, Lorena, Finck, Claudia, Frumento, Paolo, Geffken, Gary R., Geller, Daniel, Gerardi, Maryrose, Golfels, Fabian, Goodman, Wayne K., Guastella, Adam J., Gutner, Cassidy, Hendriks, Gert-Jan, Heyman, Isobel, Hofmann, Stefan G., Jovanovic, Tanja, Kushner, Matt G., Lee, Francis S., Lenze, Eric J., Levinson, Cheri A., Lewin, Adam B., Mataix-Cols, David, McConnell, Harry, McNamara, Joseph P., Monzani, Benedetta, Murphy, Tanya K., Norrholm, Seth, Otto, Michael W., Plag, Jens, Pollack, Mark H., Pérez-Vigil, Ana, Ressler, Kerry J., Rodebaugh, Thomas L., Rosenfield, David, Rothbaum, Barbara O., Rück, Christian, Scheeringa, Michael S., Siewert-Siegmund, Anja, Smits, Jasper A.J., Storch, Eric A., Ströhle, Andreas, Tart, Candyce D., Thuras, Paul, Tolin, David F., van Minnen, Agnes, Waters, Allison M., Weems, Carl F., Wilhelm, Sabine, Wyka, Katarzyna   +56 more
core   +1 more source

Combining antidepressants.

Shanghai archives of psychiatry, 2014
Treatment-resistant depression is a common problem encountered by psychiatrists. These patients are often difficult to treat effectively. Strategies for addressing patients with treatment-resistant depression include changing medications, adding another antidepressant (antidepressant polypharmacy), and augmenting treatment with a non-antidepressant.
openaire   +2 more sources

Opiates as Antidepressants

Current Pharmaceutical Design, 2009
The pathophysiology of mood disorders involves several genetic and social predisposing factors, as well as a dysregulated response to a chronic stressor, i.e. chronic pain. Our present view that depression involves a dysfunction of the monoaminergic system is a result of important clinical and preclinical observations over the past 40 years.
Berrocoso, E., Sánchez-Blázquez, Pilar, Garzón, Javier, Mico, J. A.   +3 more
openaire   +3 more sources